Combinatorial Chemistry and High Throughput Screening, volume 23, issue 10, pages 1064-1079
Design of Lamivudine Loaded Nanoparticles for Oral Application by Nano Spray Drying Method: A New Approach to use an Antiretroviral Drug for Lung Cancer Treatment
Publication type: Journal Article
Publication date: 2020-03-25
Quartile SCImago
Q3
Quartile WOS
Q3
Impact factor: 1.8
ISSN: 13862073, 18755402
Organic Chemistry
Drug Discovery
Computer Science Applications
General Medicine
Abstract
Aims:
To prepare lamivudine (LAM)-loaded-nanoparticles (NPs) that can be used in lung cancer treatment. To change the antiviral indication of LAM to anticancer.
Background:
The development of anticancer drugs is a difficult process. One approach to accelerate the availability of drugs is to reclassify drugs approved for other conditions as anticancer. The most common route of administration of anticancer drugs is intravenous injection. Oral administration of anticancer drugs may considerably change current treatment modalities of chemotherapy and improve the life quality of cancer patients. There is also a potentially significant economic advantage.
Objective:
To characterize the LAM-loaded-NPs and examine the anticancer activity.
Methods:
LAM-loaded-NPs were prepared using Nano Spray-Dryer. Properties of NPs were elucidated by particle size (PS), polydispersity index (PDI), zeta potential (ZP), SEM, encapsulation efficiency (EE%), dissolution, release kinetics, DSC and FT-IR. Then, the anticancer activity of all NPs was examined.
Results:
The PS values of the LAM-loaded-NPs were between 373 and 486 nm. All NPs prepared have spherical structure and positive ZP. EE% was in a range of 61-79%. NPs showed prolonged release and the release kinetics fitted to the Weibull model. NPs structures were clarified by DSC and FT-IR analysis. The results showed that the properties of NPs were directly related to the drug:polymer ratio of feed solution. NPs have potential anticancer properties against A549 cell line at low concentrations and non-toxic to CCD 19-Lu cell line.
Conclusion:
NPs have potential anticancer properties against human lung adenocarcinoma cells and may induce cell death effectively and be a potent modality to treat this type of cancer. These experiments also indicate that our formulations are non-toxic to normal cells. It is clear that this study would bring a new perspective to cancer therapy.
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- We do not take into account publications without a DOI.
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- Statistics recalculated weekly.
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Öztürk A. A. et al. Design of Lamivudine Loaded Nanoparticles for Oral Application by Nano Spray Drying Method: A New Approach to use an Antiretroviral Drug for Lung Cancer Treatment // Combinatorial Chemistry and High Throughput Screening. 2020. Vol. 23. No. 10. pp. 1064-1079.
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Öztürk A. A., Namlı İ., Güleç K., Görgülü Ş. Design of Lamivudine Loaded Nanoparticles for Oral Application by Nano Spray Drying Method: A New Approach to use an Antiretroviral Drug for Lung Cancer Treatment // Combinatorial Chemistry and High Throughput Screening. 2020. Vol. 23. No. 10. pp. 1064-1079.
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TY - JOUR
DO - 10.2174/1386207323666200325155020
UR - https://doi.org/10.2174/1386207323666200325155020
TI - Design of Lamivudine Loaded Nanoparticles for Oral Application by Nano Spray Drying Method: A New Approach to use an Antiretroviral Drug for Lung Cancer Treatment
T2 - Combinatorial Chemistry and High Throughput Screening
AU - Öztürk, A. Alper
AU - Namlı, İrem
AU - Güleç, Kadri
AU - Görgülü, Şennur
PY - 2020
DA - 2020/03/25 00:00:00
PB - Bentham Science
SP - 1064-1079
IS - 10
VL - 23
SN - 1386-2073
SN - 1875-5402
ER -
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@article{2020_Öztürk,
author = {A. Alper Öztürk and İrem Namlı and Kadri Güleç and Şennur Görgülü},
title = {Design of Lamivudine Loaded Nanoparticles for Oral Application by Nano Spray Drying Method: A New Approach to use an Antiretroviral Drug for Lung Cancer Treatment},
journal = {Combinatorial Chemistry and High Throughput Screening},
year = {2020},
volume = {23},
publisher = {Bentham Science},
month = {mar},
url = {https://doi.org/10.2174/1386207323666200325155020},
number = {10},
pages = {1064--1079},
doi = {10.2174/1386207323666200325155020}
}
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MLA
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Öztürk, A. Alper, et al. “Design of Lamivudine Loaded Nanoparticles for Oral Application by Nano Spray Drying Method: A New Approach to use an Antiretroviral Drug for Lung Cancer Treatment.” Combinatorial Chemistry and High Throughput Screening, vol. 23, no. 10, Mar. 2020, pp. 1064-1079. https://doi.org/10.2174/1386207323666200325155020.