Antitumour quinones.
Publication type: Journal Article
Publication date: 2005-04-30
scimago Q2
wos Q3
SJR: 0.662
CiteScore: 8.5
Impact factor: 3.3
ISSN: 13895575, 18755607
PubMed ID:
15892687
Drug Discovery
General Medicine
Pharmacology
Abstract
Quinones still comprise one of the largest classes of antitumour agents. For example, the anthracycline antibiotics are among the most utilised anticancer agents ever developed. Many other quinones were tested for their anticancer activity. Though there are general and well-established mechanisms for quinone toxicity, the exact contribution of the quinone moiety to the cytotoxic effect remains frequently uncertain. However, DNA represents the main target for quinoid antitumour agents and most of them belong to the groups of DNA intercalating and/or alkylating agents. But also other cellular structures such as heat shock protein 90 or telomerase have been identified as targets for quinoid compounds.
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Metrics
201
Total citations:
201
Citations from 2025:
6
(2.99%)
Cite this
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RIS |
BibTex |
MLA
Cite this
RIS
Copy
TY - JOUR
DO - 10.2174/1389557053765556
UR - https://doi.org/10.2174/1389557053765556
TI - Antitumour quinones.
T2 - Mini-Reviews in Medicinal Chemistry
AU - Asche, C.
PY - 2005
DA - 2005/04/30
PB - Bentham Science Publishers Ltd.
SP - 449-467
IS - 5
VL - 5
PMID - 15892687
SN - 1389-5575
SN - 1875-5607
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2005_Asche,
author = {C. Asche},
title = {Antitumour quinones.},
journal = {Mini-Reviews in Medicinal Chemistry},
year = {2005},
volume = {5},
publisher = {Bentham Science Publishers Ltd.},
month = {apr},
url = {https://doi.org/10.2174/1389557053765556},
number = {5},
pages = {449--467},
doi = {10.2174/1389557053765556}
}
Cite this
MLA
Copy
Asche, C.. “Antitumour quinones..” Mini-Reviews in Medicinal Chemistry, vol. 5, no. 5, Apr. 2005, pp. 449-467. https://doi.org/10.2174/1389557053765556.