A Review of the Pharmacological Properties of 3,4-dihydro-2(1H)- quinolinones
Publication type: Journal Article
Publication date: 2017-10-04
scimago Q2
wos Q3
SJR: 0.662
CiteScore: 8.5
Impact factor: 3.3
ISSN: 13895575, 18755607
PubMed ID:
28971767
Drug Discovery
General Medicine
Pharmacology
Abstract
The 3,4-dihydro-2(1H)-quinolinone moiety is present in a number of pharmacologically active compounds. These include FDA approved drugs such as cilostazol, carteolol and aripiprazole as well as numerous experimental compounds. Compounds containing the 3,4-dihydro-2(1H)-quinolinone moiety also exhibit a variety of activities in both the peripheral and central tissues, which includes phosphodiesterase inhibition, blocking of β-adrenergic receptors, antagonism of vasopressin receptors and interaction with serotonin and dopamine receptors. Based on its versatility in drug design and action, this paper reviews the pharmacological actions of compounds containing the 3,4-dihydro-2(1H)- quinolinone scaffold with emphasis being placed on the most important and significant members of each activity class.
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18
Total citations:
18
Citations from 2025:
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GOST
Copy
Meiring L., Petzer J. P., Petzer A. A Review of the Pharmacological Properties of 3,4-dihydro-2(1H)- quinolinones // Mini-Reviews in Medicinal Chemistry. 2017. Vol. 18. No. 10. pp. 828-836.
GOST all authors (up to 50)
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Meiring L., Petzer J. P., Petzer A. A Review of the Pharmacological Properties of 3,4-dihydro-2(1H)- quinolinones // Mini-Reviews in Medicinal Chemistry. 2017. Vol. 18. No. 10. pp. 828-836.
Cite this
RIS
Copy
TY - JOUR
DO - 10.2174/1389557517666170927141323
UR - https://doi.org/10.2174/1389557517666170927141323
TI - A Review of the Pharmacological Properties of 3,4-dihydro-2(1H)- quinolinones
T2 - Mini-Reviews in Medicinal Chemistry
AU - Meiring, Letitia
AU - Petzer, J. P.
AU - Petzer, Anel
PY - 2017
DA - 2017/10/04
PB - Bentham Science Publishers Ltd.
SP - 828-836
IS - 10
VL - 18
PMID - 28971767
SN - 1389-5575
SN - 1875-5607
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2017_Meiring,
author = {Letitia Meiring and J. P. Petzer and Anel Petzer},
title = {A Review of the Pharmacological Properties of 3,4-dihydro-2(1H)- quinolinones},
journal = {Mini-Reviews in Medicinal Chemistry},
year = {2017},
volume = {18},
publisher = {Bentham Science Publishers Ltd.},
month = {oct},
url = {https://doi.org/10.2174/1389557517666170927141323},
number = {10},
pages = {828--836},
doi = {10.2174/1389557517666170927141323}
}
Cite this
MLA
Copy
Meiring, Letitia, et al. “A Review of the Pharmacological Properties of 3,4-dihydro-2(1H)- quinolinones.” Mini-Reviews in Medicinal Chemistry, vol. 18, no. 10, Oct. 2017, pp. 828-836. https://doi.org/10.2174/1389557517666170927141323.