Current Topics in Medicinal Chemistry, volume 16, issue 15, pages 1705-1716
Linking Biosynthetic Gene Clusters to their Metabolites via Pathway- Targeted Molecular Networking
Publication type: Journal Article
Publication date: 2015-10-15
Quartile SCImago
Q2
Quartile WOS
Q3
Impact factor: 3.4
ISSN: 15680266, 18734294
PubMed ID:
26456470
Drug Discovery
General Medicine
Abstract
The connection of microbial biosynthetic gene clusters to the small molecule metabolites they encode is central to the discovery and characterization of new metabolic pathways with ecological and pharmacological potential. With increasing microbial genome sequence information being deposited into publicly available databases, it is clear that microbes have the coding capacity for many more biologically active small molecules than previously realized. Of increasing interest are the small molecules encoded by the human microbiome, as these metabolites likely mediate a variety of currently uncharacterized human-microbe interactions that influence health and disease. In this mini-review, we describe the ongoing biosynthetic, structural, and functional characterizations of the genotoxic colibactin pathway in gut bacteria as a thematic example of linking biosynthetic gene clusters to their metabolites. We also highlight other natural products that are produced through analogous biosynthetic logic and comment on some current disconnects between bioinformatics predictions and experimental structural characterizations. Lastly, we describe the use of pathway-targeted molecular networking as a tool to characterize secondary metabolic pathways within complex metabolomes and to aid in downstream metabolite structural elucidation efforts.
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Citations by publishers
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1 publication, 3.13%
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Frontiers Media S.A.
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American Association for the Advancement of Science (AAAS)
1 publication, 3.13%
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Public Library of Science (PLoS)
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1 publication, 3.13%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Trautman E., Crawford J. B. Linking Biosynthetic Gene Clusters to their Metabolites via Pathway- Targeted Molecular Networking // Current Topics in Medicinal Chemistry. 2015. Vol. 16. No. 15. pp. 1705-1716.
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Trautman E., Crawford J. B. Linking Biosynthetic Gene Clusters to their Metabolites via Pathway- Targeted Molecular Networking // Current Topics in Medicinal Chemistry. 2015. Vol. 16. No. 15. pp. 1705-1716.
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TY - JOUR
DO - 10.2174/1568026616666151012111046
UR - https://doi.org/10.2174%2F1568026616666151012111046
TI - Linking Biosynthetic Gene Clusters to their Metabolites via Pathway- Targeted Molecular Networking
T2 - Current Topics in Medicinal Chemistry
AU - Trautman, E
AU - Crawford, Jason B.
PY - 2015
DA - 2015/10/15 00:00:00
PB - Bentham Science
SP - 1705-1716
IS - 15
VL - 16
PMID - 26456470
SN - 1568-0266
SN - 1873-4294
ER -
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@article{2015_Trautman,
author = {E Trautman and Jason B. Crawford},
title = {Linking Biosynthetic Gene Clusters to their Metabolites via Pathway- Targeted Molecular Networking},
journal = {Current Topics in Medicinal Chemistry},
year = {2015},
volume = {16},
publisher = {Bentham Science},
month = {oct},
url = {https://doi.org/10.2174%2F1568026616666151012111046},
number = {15},
pages = {1705--1716},
doi = {10.2174/1568026616666151012111046}
}
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Trautman, E., and Jason B. Crawford. “Linking Biosynthetic Gene Clusters to their Metabolites via Pathway- Targeted Molecular Networking.” Current Topics in Medicinal Chemistry, vol. 16, no. 15, Oct. 2015, pp. 1705-1716. https://doi.org/10.2174%2F1568026616666151012111046.