Current Organic Synthesis

, volume 16 , issue 7 , pages 968-1001

Flavones as a Privileged Scaffold in Drug Discovery: Current Developments

Pone K. Boniface ¹

Ferreira I. Elizabeth ¹

Hide authors affiliations Show authors affiliations: 1 affiliation

Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil |

Publication type: Journal Article

Publication date: 2019-07-23

Bentham Science Publishers Ltd.

Current Organic Synthesis

scimago Q3

wos Q2

SJR: 0.377

CiteScore: 4.0

Impact factor: 2.5

ISSN: 15701794, 18756271

DOI: 10.2174/1570179416666190719125730

Copy DOI

PubMed ID: 31984880

Organic Chemistry

Biochemistry

Abstract

Background:

Flavones are one of the main subclasses of flavonoids with diverse pharmacological properties. They have been reported to possess antimalarial, antimicrobial, anti-tuberculosis, anti-allergic, antioxidant, anti-inflammatory activities, among others.

Objective:

The present review summarizes the recent information on the pharmacological properties of naturally occurring and synthetic flavones.

Method:

Scientific publications referring to natural and synthetic flavones in relation to their biological activities were hand-searched in databases such as SciFinder, PubMed (National Library of Medicine), Science Direct, Wiley, ACS, SciELO, Springer, among others.

Results:

As per the literature, seventy-five natural flavones were predicted as active compounds with reference to their IC50 (<20 µg/mL) in in vitro studies. Also, synthetic flavones were found active against several diseases.

Conclusion:

As per the literature, flavones are important sources for the potential treatment of multifactorial diseases. However, efforts toward the development of flavone-based therapeutic agents are still needed. The appearance of new catalysts and chemical transformations is expected to provide avenues for the synthesis of unexplored flavones, leading to the discovery of flavones with new properties and biological activities.

Found

1 citation

Beloglazkina Elena

DSc in Chemistry, professor

296 publications, 3 248 citations, 11 reviews

h-index: 29

Lomonosov Moscow State University

1 citation

Luponosov Yuriy

🥼 🤝

DSc in Chemistry

113 publications, 2 526 citations, 13 reviews

h-index: 27

Enikolopov Institute of Synthetic Polymeric Materials of the Russian Academy of Sciences

1 citation

Vil' Vera

PhD in Chemistry

86 publications, 1 967 citations, 3 reviews

h-index: 24

N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences

Research interests

Organic Chemistry

1 citation

Yaremenko Ivan

PhD in Chemistry

60 publications, 1 567 citations, 5 reviews

h-index: 24

N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences

Research interests

Organic Chemistry

1 citation

Gorbunova Yuliya

DSc in Chemistry, professor, full member of the Russian Academy of Sciences

284 publications, 4 398 citations, 65 reviews

h-index: 34

Lomonosov Moscow State University

Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences

A.N. Frumkin Institute of Physical Chemistry and Electrochemistry of the Russian Academy of Sciences

Research interests

Coordination Chemistry

Lanthanides

Supramolecular chemistry

Tetrapyrrolic compounds

1 citation

Volcho Konstantin

DSc in Chemistry, professor of the Russian Academy of Sciences

279 publications, 3 898 citations, 65 reviews

h-index: 31

N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Siberian Branch of the Russian Academy of Sciences

1 citation

Danilkina Natalia

44 publications, 625 citations

h-index: 14

Saint Petersburg State University

Research interests

Bioorganic chemistry

Click chemistry

Heterocyclic compounds

Medicinal Chemistry

Organic Chemistry

1 citation

Osipov Sergey

DSc in Chemistry

138 publications, 2 739 citations, 3 reviews

h-index: 29

A.N.Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences

1 citation

Gazizov Almir

🥼

DSc in Chemistry

157 publications, 889 citations, 23 reviews

h-index: 14

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

Research interests

Heterocyclic compounds

Organic Chemistry

Organophosphorus chemistry

1 citation

Karasik Andrey

DSc in Chemistry, professor, associate member of the Russian Academy of Sciences

224 publications, 2 599 citations

h-index: 26

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

Research interests

Coordination Chemistry

Luminescence

Phosphorus ligands

1 citation

Dotsenko Viktor

DSc in Chemistry, professor

244 publications, 2 741 citations, 2 reviews

h-index: 22

North Caucasus Federal University

Kuban State University

Research interests

Active methylene compounds

Biological activity

Heterocyclic compounds

Malononitrile

Selenoamides

Thioamides

1 citation

Zagidullin Almaz

🥼 🤝

PhD in Chemistry

81 publications, 884 citations

h-index: 17

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

Research interests

Asymmetric metal complex catalysis

Chemistry of organic and organoelement compounds; chemistry of polymers; production of materials

Coordination chemistry of phosphorus

Organoelement chemistry

Organophosphorus chemistry

Synthesis of chiral phosphorus-containing ligands

1 citation

Aksenov Aleksandr

🥼 🤝

DSc in Chemistry, professor

243 publications, 2 187 citations, 15 reviews

h-index: 24

North Caucasus Federal University

Research interests

Medicinal Chemistry

Organic Chemistry

1 citation

Sosnovskikh Vyacheslav

DSc in Chemistry, professor

355 publications, 4 721 citations

h-index: 30

Ural Federal University

1 citation

Ilkin Vladimir

PhD in Chemistry

16 publications, 187 citations

h-index: 7

Ural Federal University

Research interests

Catalysis

Heterocyclic compounds

Organic Chemistry

Synthetic Organic Chemistry

1 citation

Krylov Igor

PhD in Chemistry

78 publications, 1 885 citations, 18 reviews

h-index: 25

N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences

Research interests

Green chemistry

Organic Chemistry

Organic electrochemistry

Organic synthesis

Photochemistry

Plant protection

1 citation

Tikhomirov Alexander

🥼 🤝

DSc in Chemistry, associate professor

59 publications, 920 citations

h-index: 17

Mendeleev University of Chemical Technology of Russia

Gause Institute of New Antibiotics

Research interests

Medicinal Chemistry

1 citation

Ivanov Andrey

54 publications, 534 citations

h-index: 12

A.E. Favorsky Irkutsk Institute of Chemistry of the Siberian Branch of the Russian Academy of Sciences

1 citation

Buev Evgeny

PhD in Chemistry

31 publications, 346 citations, 2 reviews

h-index: 9

Ural Federal University

Research interests

Chemistry of nitrogen-containing heterocycles

Organic Chemistry

Organic synthesis

Top-30

Journals

	1 2
Journal of Agricultural and Food Chemistry	Journal of Agricultural and Food Chemistry, 2, 5.88% Journal of Agricultural and Food Chemistry 2 publications, 5.88%
Pharmaceuticals	Pharmaceuticals, 2, 5.88% Pharmaceuticals 2 publications, 5.88%
Frontiers in Pharmacology	Frontiers in Pharmacology, 2, 5.88% Frontiers in Pharmacology 2 publications, 5.88%
Journal of Fluorine Chemistry	Journal of Fluorine Chemistry, 2, 5.88% Journal of Fluorine Chemistry 2 publications, 5.88%
Phytomedicine	Phytomedicine, 2, 5.88% Phytomedicine 2 publications, 5.88%
Journal of Molecular Structure	Journal of Molecular Structure, 2, 5.88% Journal of Molecular Structure 2 publications, 5.88%
Central Nervous System Agents in Medicinal Chemistry	Central Nervous System Agents in Medicinal Chemistry, 1, 2.94% Central Nervous System Agents in Medicinal Chemistry 1 publication, 2.94%
Phytochemical Analysis	Phytochemical Analysis, 1, 2.94% Phytochemical Analysis 1 publication, 2.94%
Biological and Pharmaceutical Bulletin	Biological and Pharmaceutical Bulletin, 1, 2.94% Biological and Pharmaceutical Bulletin 1 publication, 2.94%
Journal of Physical Chemistry A	Journal of Physical Chemistry A, 1, 2.94% Journal of Physical Chemistry A 1 publication, 2.94%
Processes	Processes, 1, 2.94% Processes 1 publication, 2.94%
Biomolecules	Biomolecules, 1, 2.94% Biomolecules 1 publication, 2.94%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 1, 2.94% International Journal of Molecular Sciences 1 publication, 2.94%
Chinese Medicine	Chinese Medicine, 1, 2.94% Chinese Medicine 1 publication, 2.94%
Membranes	Membranes, 1, 2.94% Membranes 1 publication, 2.94%
Phytotherapy Research	Phytotherapy Research, 1, 2.94% Phytotherapy Research 1 publication, 2.94%
ChemistrySelect	ChemistrySelect, 1, 2.94% ChemistrySelect 1 publication, 2.94%
Asian Journal of Chemistry	Asian Journal of Chemistry, 1, 2.94% Asian Journal of Chemistry 1 publication, 2.94%
Organic and Biomolecular Chemistry	Organic and Biomolecular Chemistry, 1, 2.94% Organic and Biomolecular Chemistry 1 publication, 2.94%
Molecular Diversity	Molecular Diversity, 1, 2.94% Molecular Diversity 1 publication, 2.94%
Pharmacia	Pharmacia, 1, 2.94% Pharmacia 1 publication, 2.94%
Russian Chemical Reviews	Russian Chemical Reviews, 1, 2.94% Russian Chemical Reviews 1 publication, 2.94%
Organic Process Research and Development	Organic Process Research and Development, 1, 2.94% Organic Process Research and Development 1 publication, 2.94%
Journal of Drug Delivery Science and Technology	Journal of Drug Delivery Science and Technology, 1, 2.94% Journal of Drug Delivery Science and Technology 1 publication, 2.94%
Drugs and Drug Candidates	Drugs and Drug Candidates, 1, 2.94% Drugs and Drug Candidates 1 publication, 2.94%
ChemMedChem	ChemMedChem, 1, 2.94% ChemMedChem 1 publication, 2.94%
Reactions	Reactions, 1, 2.94% Reactions 1 publication, 2.94%
Digital Chinese Medicine	Digital Chinese Medicine, 1, 2.94% Digital Chinese Medicine 1 publication, 2.94%
	1 2

Publishers

	1 2 3 4 5 6 7 8
MDPI	MDPI, 8, 23.53% MDPI 8 publications, 23.53%
Elsevier	Elsevier, 8, 23.53% Elsevier 8 publications, 23.53%
Wiley	Wiley, 4, 11.76% Wiley 4 publications, 11.76%
American Chemical Society (ACS)	American Chemical Society (ACS), 4, 11.76% American Chemical Society (ACS) 4 publications, 11.76%
Frontiers Media S.A.	Frontiers Media S.A., 2, 5.88% Frontiers Media S.A. 2 publications, 5.88%
Springer Nature	Springer Nature, 2, 5.88% Springer Nature 2 publications, 5.88%
Bentham Science Publishers Ltd.	Bentham Science Publishers Ltd., 1, 2.94% Bentham Science Publishers Ltd. 1 publication, 2.94%
Pharmaceutical Society of Japan	Pharmaceutical Society of Japan, 1, 2.94% Pharmaceutical Society of Japan 1 publication, 2.94%
Asian Journal of Chemistry	Asian Journal of Chemistry, 1, 2.94% Asian Journal of Chemistry 1 publication, 2.94%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 1, 2.94% Royal Society of Chemistry (RSC) 1 publication, 2.94%
Pensoft Publishers	Pensoft Publishers, 1, 2.94% Pensoft Publishers 1 publication, 2.94%
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii	Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii, 1, 2.94% Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii 1 publication, 2.94%
	1 2 3 4 5 6 7 8

We do not take into account publications without a DOI.
Statistics recalculated weekly.

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.

Metrics

Cite this

GOST |

Cite this

GOST Copy

Boniface P. K., Elizabeth F. I. Flavones as a Privileged Scaffold in Drug Discovery: Current Developments // Current Organic Synthesis. 2019. Vol. 16. No. 7. pp. 968-1001.

GOST all authors (up to 50) Copy

Boniface P. K., Elizabeth F. I. Flavones as a Privileged Scaffold in Drug Discovery: Current Developments // Current Organic Synthesis. 2019. Vol. 16. No. 7. pp. 968-1001.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.2174/1570179416666190719125730

UR - https://doi.org/10.2174/1570179416666190719125730

TI - Flavones as a Privileged Scaffold in Drug Discovery: Current Developments

T2 - Current Organic Synthesis

AU - Boniface, Pone K.

AU - Elizabeth, Ferreira I.

PY - 2019

DA - 2019/07/23

PB - Bentham Science Publishers Ltd.

SP - 968-1001

IS - 7

VL - 16

PMID - 31984880

SN - 1570-1794

SN - 1875-6271

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2019_Boniface,

author = {Pone K. Boniface and Ferreira I. Elizabeth},

title = {Flavones as a Privileged Scaffold in Drug Discovery: Current Developments},

journal = {Current Organic Synthesis},

year = {2019},

volume = {16},

publisher = {Bentham Science Publishers Ltd.},

month = {jul},

url = {https://doi.org/10.2174/1570179416666190719125730},

number = {7},

pages = {968--1001},

doi = {10.2174/1570179416666190719125730}

}

MLA

Cite this

MLA Copy

Boniface, Pone K., and Ferreira I. Elizabeth. “Flavones as a Privileged Scaffold in Drug Discovery: Current Developments.” Current Organic Synthesis, vol. 16, no. 7, Jul. 2019, pp. 968-1001. https://doi.org/10.2174/1570179416666190719125730.

Publisher

Bentham Science Publishers Ltd.

Journal

Current Organic Synthesis

scimago Q3

wos Q2

SJR

0.377

CiteScore

4.0

Impact factor

2.5

ISSN

15701794 (Print)

18756271 (Electronic)