Flavones as a Privileged Scaffold in Drug Discovery: Current Developments
Background:
Flavones are one of the main subclasses of flavonoids with diverse pharmacological properties. They have been reported to possess antimalarial, antimicrobial, anti-tuberculosis, anti-allergic, antioxidant, anti-inflammatory activities, among others.
Objective:
The present review summarizes the recent information on the pharmacological properties of naturally occurring and synthetic flavones.
Method:
Scientific publications referring to natural and synthetic flavones in relation to their biological activities were hand-searched in databases such as SciFinder, PubMed (National Library of Medicine), Science Direct, Wiley, ACS, SciELO, Springer, among others.
Results:
As per the literature, seventy-five natural flavones were predicted as active compounds with reference to their IC50 (<20 µg/mL) in in vitro studies. Also, synthetic flavones were found active against several diseases.
Conclusion:
As per the literature, flavones are important sources for the potential treatment of multifactorial diseases. However, efforts toward the development of flavone-based therapeutic agents are still needed. The appearance of new catalysts and chemical transformations is expected to provide avenues for the synthesis of unexplored flavones, leading to the discovery of flavones with new properties and biological activities.
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Journal of Agricultural and Food Chemistry
2 публикации, 5.88%
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Pharmaceuticals
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Frontiers in Pharmacology
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Journal of Fluorine Chemistry
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Phytomedicine
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Journal of Molecular Structure
2 публикации, 5.88%
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Central Nervous System Agents in Medicinal Chemistry
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Phytochemical Analysis
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Biological and Pharmaceutical Bulletin
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Journal of Physical Chemistry A
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Processes
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Biomolecules
1 публикация, 2.94%
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International Journal of Molecular Sciences
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Chinese Medicine
1 публикация, 2.94%
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Membranes
1 публикация, 2.94%
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Phytotherapy Research
1 публикация, 2.94%
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ChemistrySelect
1 публикация, 2.94%
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Asian Journal of Chemistry
1 публикация, 2.94%
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Organic and Biomolecular Chemistry
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Molecular Diversity
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Pharmacia
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Russian Chemical Reviews
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Organic Process Research and Development
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Journal of Drug Delivery Science and Technology
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Drugs and Drug Candidates
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ChemMedChem
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Reactions
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Digital Chinese Medicine
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MDPI
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Elsevier
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Wiley
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American Chemical Society (ACS)
4 публикации, 11.76%
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Frontiers Media S.A.
2 публикации, 5.88%
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Springer Nature
2 публикации, 5.88%
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Bentham Science Publishers Ltd.
1 публикация, 2.94%
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Pharmaceutical Society of Japan
1 публикация, 2.94%
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Asian Journal of Chemistry
1 публикация, 2.94%
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Royal Society of Chemistry (RSC)
1 публикация, 2.94%
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Pensoft Publishers
1 публикация, 2.94%
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
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- Мы не учитываем публикации, у которых нет DOI.
- Статистика публикаций обновляется еженедельно.