Potent Neuroprotective Activity of Monoterpene Derived 4-[(3aR,7aS)- 1,3,3a,4,5,7a-Hexahydro-3,3,6-trimethylisobenzofuran-1-yl]-2-methoxyphenol in MPTP Mice Model
Publication type: Journal Article
Publication date: 2013-12-09
scimago Q3
wos Q4
SJR: 0.310
CiteScore: 1.8
Impact factor: 1.6
ISSN: 15701808, 1875628X
Drug Discovery
Pharmaceutical Science
Molecular Medicine
Abstract
Studies of the neuroprotective activity of a series of monoterpene-derived compounds on the MPTP mice model showed that 4-[(3aR,7aS)-1,3,3a,4,5,7a-hexahydro-3,3,6-trimethylisobenzofuran-1-yl]-2-methoxyphenol 15 possessed a considerable neuroprotective activity. Compound 15 was synthesized by one-stage reaction of (+)-2-carene with vanillin. It has low acute toxicity and significantly decreased the development of catalepsy evoked by haloperidol in rats.
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Total citations:
12
Citations from 2024:
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(25%)
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Pavlova A. et al. Potent Neuroprotective Activity of Monoterpene Derived 4-[(3aR,7aS)- 1,3,3a,4,5,7a-Hexahydro-3,3,6-trimethylisobenzofuran-1-yl]-2-methoxyphenol in MPTP Mice Model // Letters in Drug Design and Discovery. 2013. Vol. 11. No. 5. pp. 611-617.
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Pavlova A., Ilina I., Morozova E., Korchagina D., Kurbakova S., Sorokina I., Tolstikova T., Volcho K., Salakhutdinov N. Potent Neuroprotective Activity of Monoterpene Derived 4-[(3aR,7aS)- 1,3,3a,4,5,7a-Hexahydro-3,3,6-trimethylisobenzofuran-1-yl]-2-methoxyphenol in MPTP Mice Model // Letters in Drug Design and Discovery. 2013. Vol. 11. No. 5. pp. 611-617.
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TY - JOUR
DO - 10.2174/1570180811666131210000316
UR - https://doi.org/10.2174/1570180811666131210000316
TI - Potent Neuroprotective Activity of Monoterpene Derived 4-[(3aR,7aS)- 1,3,3a,4,5,7a-Hexahydro-3,3,6-trimethylisobenzofuran-1-yl]-2-methoxyphenol in MPTP Mice Model
T2 - Letters in Drug Design and Discovery
AU - Pavlova, Alla
AU - Ilina, Irina
AU - Morozova, Ekaterina
AU - Korchagina, Dina
AU - Kurbakova, Svetlana
AU - Sorokina, Irina
AU - Tolstikova, Tatyana
AU - Volcho, Konstantin
AU - Salakhutdinov, Nariman
PY - 2013
DA - 2013/12/09
PB - Bentham Science Publishers Ltd.
SP - 611-617
IS - 5
VL - 11
SN - 1570-1808
SN - 1875-628X
ER -
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BibTex (up to 50 authors)
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@article{2013_Pavlova,
author = {Alla Pavlova and Irina Ilina and Ekaterina Morozova and Dina Korchagina and Svetlana Kurbakova and Irina Sorokina and Tatyana Tolstikova and Konstantin Volcho and Nariman Salakhutdinov},
title = {Potent Neuroprotective Activity of Monoterpene Derived 4-[(3aR,7aS)- 1,3,3a,4,5,7a-Hexahydro-3,3,6-trimethylisobenzofuran-1-yl]-2-methoxyphenol in MPTP Mice Model},
journal = {Letters in Drug Design and Discovery},
year = {2013},
volume = {11},
publisher = {Bentham Science Publishers Ltd.},
month = {dec},
url = {https://doi.org/10.2174/1570180811666131210000316},
number = {5},
pages = {611--617},
doi = {10.2174/1570180811666131210000316}
}
Cite this
MLA
Copy
Pavlova, Alla, et al. “Potent Neuroprotective Activity of Monoterpene Derived 4-[(3aR,7aS)- 1,3,3a,4,5,7a-Hexahydro-3,3,6-trimethylisobenzofuran-1-yl]-2-methoxyphenol in MPTP Mice Model.” Letters in Drug Design and Discovery, vol. 11, no. 5, Dec. 2013, pp. 611-617. https://doi.org/10.2174/1570180811666131210000316.