Novel Trifluoromethylpyrazole Acyl Thiourea Derivatives: Synthesis, Antifungal Activity and Docking Study
Тип публикации: Journal Article
Дата публикации: 2018-07-05
SCImago Q3
WOS Q4
БС3
SJR: 0.301
CiteScore: 2.2
Impact factor: 1.6
ISSN: 15701808, 1875628X
Drug Discovery
Pharmaceutical Science
Molecular Medicine
Краткое описание
Background:
In recent years, pyrazole carboxamide derivatives possessed excellent fungicidal activity. In the process of designing new fungicides, the carboxamide group was modified in order to find novel structure pyrazole carboxamide derivatives.
Methods:
Ten novel trifluoromethyl pyrazole acyl thiourea derivatives were designed and synthesized. In vivo fungicidal activities of these compounds were tested against Fusarium oxysporum, Corynespora mazei and Botrytis cinerea, respectively
Results:
Particularly compounds exhibited significant control effective at 100 mg/L. More importantly, some compounds showed the good control effective at 10 mg/L. Furthermore, docking was established to study the structure-activity relationship of the title compounds.
Conclusion:
It is possible that trifluoromethylpyrazole acyl thiurea derivatives, which possess good control effective against Botrytis cinerea, may become novel lead compounds for the development of fungicides with further structure modification.
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ГОСТ
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Wang H. et al. Novel Trifluoromethylpyrazole Acyl Thiourea Derivatives: Synthesis, Antifungal Activity and Docking Study // Letters in Drug Design and Discovery. 2018. Vol. 16. No. 7. pp. 785-791.
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Wang H., Zhai Z., Shi Y., Tan C., Weng J., Han L., Li B., LIU X. Novel Trifluoromethylpyrazole Acyl Thiourea Derivatives: Synthesis, Antifungal Activity and Docking Study // Letters in Drug Design and Discovery. 2018. Vol. 16. No. 7. pp. 785-791.
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TY - JOUR
DO - 10.2174/1570180815666180704103047
UR - https://doi.org/10.2174/1570180815666180704103047
TI - Novel Trifluoromethylpyrazole Acyl Thiourea Derivatives: Synthesis, Antifungal Activity and Docking Study
T2 - Letters in Drug Design and Discovery
AU - Wang, Han
AU - Zhai, Zhi-Wen
AU - Shi, Yan-Xia
AU - Tan, Cheng-Xia
AU - Weng, Jian-Quan
AU - Han, Liang
AU - Li, Bao-Ju
AU - LIU, XING-HAI
PY - 2018
DA - 2018/07/05
PB - Bentham Science Publishers Ltd.
SP - 785-791
IS - 7
VL - 16
SN - 1570-1808
SN - 1875-628X
ER -
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@article{2018_Wang,
author = {Han Wang and Zhi-Wen Zhai and Yan-Xia Shi and Cheng-Xia Tan and Jian-Quan Weng and Liang Han and Bao-Ju Li and XING-HAI LIU},
title = {Novel Trifluoromethylpyrazole Acyl Thiourea Derivatives: Synthesis, Antifungal Activity and Docking Study},
journal = {Letters in Drug Design and Discovery},
year = {2018},
volume = {16},
publisher = {Bentham Science Publishers Ltd.},
month = {jul},
url = {https://doi.org/10.2174/1570180815666180704103047},
number = {7},
pages = {785--791},
doi = {10.2174/1570180815666180704103047}
}
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MLA
Скопировать
Wang, Han, et al. “Novel Trifluoromethylpyrazole Acyl Thiourea Derivatives: Synthesis, Antifungal Activity and Docking Study.” Letters in Drug Design and Discovery, vol. 16, no. 7, Jul. 2018, pp. 785-791. https://doi.org/10.2174/1570180815666180704103047.
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