CNS and Neurological Disorders - Drug Targets, volume 21, issue 3, pages 278-289
Neurokinin-1 Receptor Antagonist Reverses Functional CNS Alteration Caused by Combined γ-rays and Carbon Nuclei Irradiation
Kokhan Viktor S.
1
,
Mariasina Sofia
2
,
Pikalov Vladimir A.
3
,
Абаимов Д. А.
4
,
Somasundaram Siva G.
5
,
Kirkland Cecil E.
5
,
Aliev Gjumrakch
6
5
Department
of Biological Sciences, Salem University, Salem, WV 26426, USA
|
6
I.M. Sechenov First Moscow State Medical University,
Ministry of Health of the Russian Federation, Sechenov University, 8/2 Trubetskaya Str., Moscow 119991, Russia | Research Institute of Human Morphology,3 Tsyurupy Street, Moscow 117418, Russian Federation | Institute of
Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka 142432, Russia | GALLY International
Research Institute, 7733 Louis Pasteur Drive, #330, San Antonio, TX 78229, USA
|
Publication type: Journal Article
Publication date: 2022-03-01
Quartile SCImago
Q2
Quartile WOS
Q3
Impact factor: 3
ISSN: 18715273
Pharmacology
General Neuroscience
Abstract
Background:
Ionizing Radiation (IR) is one of the major limiting factors for human deep-space missions. Preventing IR-induced cognitive alterations in astronauts is a critical success factor. It has been shown that cognitive alterations in rodents can be inferred by alterations of a psycho- emotional balance, primarily an anxiogenic effect of IR. In our recent work, we hypothesized that the neurokinin-1 (NK1) receptor might be instrumental for such alterations.
Objective:
The NK1 receptor antagonist rolapitant and the classic anxiolytic diazepam (as a comparison drug) were selected to test this hypothesis on Wistar rats.
Method:
Pharmacological substances were administered through intragastric probes. We used a battery of tests for a comprehensive ethological analysis. High-performance liquid chromatography was applied to quantify monoamines content. An analysis of mRNA expression was performed by real-time PCR. Protein content was studied by the Western blotting technique.
Results:
Our salient finding includes no substantial changes in anxiety, locomotor activity and cognitive abilities of treated rats under irradiation. No differences were found in the content of monoamines. We discovered a synchronous effect on mRNA expression and protein content of 5- HT2a and 5-HT4 receptors in the prefrontal cortex, as well as decreased content of serotonin transporter and increased content of tryptophan hydroxylase in the hypothalamus of irradiated rats. Rolapitant affected the protein amount of a number of serotonin receptors in the amygdala of irradiated rats.
Conclusion :
Rolapitant may be the first atypical radioprotector, providing symptomatic treatment of CNS functional disorders in astronauts caused by IR.
Citations by journals
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Biology
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1 publication, 16.67%
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Life
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1 publication, 16.67%
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FEBS Journal
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FEBS Journal
1 publication, 16.67%
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Toxics
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1 publication, 16.67%
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Doklady Biological Sciences
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1 publication, 16.67%
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Radiation
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Radiation
1 publication, 16.67%
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1
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Citations by publishers
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1
2
3
4
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
4 publications, 66.67%
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Wiley
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Wiley
1 publication, 16.67%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 16.67%
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1
2
3
4
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Kokhan V. S. et al. Neurokinin-1 Receptor Antagonist Reverses Functional CNS Alteration Caused by Combined γ-rays and Carbon Nuclei Irradiation // CNS and Neurological Disorders - Drug Targets. 2022. Vol. 21. No. 3. pp. 278-289.
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Kokhan V. S., Mariasina S., Pikalov V. A., Абаимов Д. А., Somasundaram S. G., Kirkland C. E., Aliev G. Neurokinin-1 Receptor Antagonist Reverses Functional CNS Alteration Caused by Combined γ-rays and Carbon Nuclei Irradiation // CNS and Neurological Disorders - Drug Targets. 2022. Vol. 21. No. 3. pp. 278-289.
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TY - JOUR
DO - 10.2174/1871527320666210122092330
UR - https://doi.org/10.2174%2F1871527320666210122092330
TI - Neurokinin-1 Receptor Antagonist Reverses Functional CNS Alteration Caused by Combined γ-rays and Carbon Nuclei Irradiation
T2 - CNS and Neurological Disorders - Drug Targets
AU - Kokhan, Viktor S.
AU - Mariasina, Sofia
AU - Pikalov, Vladimir A.
AU - Абаимов, Д. А.
AU - Somasundaram, Siva G.
AU - Kirkland, Cecil E.
AU - Aliev, Gjumrakch
PY - 2022
DA - 2022/03/01 00:00:00
PB - Bentham Science
SP - 278-289
IS - 3
VL - 21
SN - 1871-5273
ER -
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@article{2022_Kokhan,
author = {Viktor S. Kokhan and Sofia Mariasina and Vladimir A. Pikalov and Д. А. Абаимов and Siva G. Somasundaram and Cecil E. Kirkland and Gjumrakch Aliev},
title = {Neurokinin-1 Receptor Antagonist Reverses Functional CNS Alteration Caused by Combined γ-rays and Carbon Nuclei Irradiation},
journal = {CNS and Neurological Disorders - Drug Targets},
year = {2022},
volume = {21},
publisher = {Bentham Science},
month = {mar},
url = {https://doi.org/10.2174%2F1871527320666210122092330},
number = {3},
pages = {278--289},
doi = {10.2174/1871527320666210122092330}
}
Cite this
MLA
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Kokhan, Viktor S., et al. “Neurokinin-1 Receptor Antagonist Reverses Functional CNS Alteration Caused by Combined γ-rays and Carbon Nuclei Irradiation.” CNS and Neurological Disorders - Drug Targets, vol. 21, no. 3, Mar. 2022, pp. 278-289. https://doi.org/10.2174%2F1871527320666210122092330.