Future Virology

, volume 18 , issue 13 , pages 865-880

Antiviral evaluation of 1,4-disubstituted-1,2,3-triazole derivatives against Chikungunya virus

Vitor Won Held Rabelo ¹

Verônica Diniz Da Silva ²

Maria Leonisa Sanchez Nuñez ¹

Leonardo dos Santos Corrêa Amorim ^{1, 3}

Camilla D Buarque ²

R. Kuhn ^{4, 5}

Paula Alvarez Abreu ⁶

Izabel C. Paixão ^{1, 7, 8}

Hide authors affiliations Show authors affiliations: 8 affiliations

Programa de Pós-graduação em Ciências e Biotecnologia, Instituto de Biologia, Universidade Federal Fluminense, Niterói, RJ, CEP, 24210-201, Brazil |

Laboratório de Síntese Orgânica, Pontifícia Universidade Católica do Rio de Janeiro, Rio de Janeiro, RJ, CEP, 22451-900, Brazil |

Gerência de Desenvolvimento Tecnológico, Instituto Vital Brazil, Niterói, RJ, 24230-410, Brazil |

⁴

Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA |

⁵

Purdue Institute of Inflammation, Immunology, & Infectious Disease, Purdue University, West Lafayette, IN 47907, USA |

⁶

Instituto de Biodiversidade e Sustentabilidade (NUPEM), Universidade Federal do Rio de Janeiro, Macaé, RJ, CEP, 27965-045, Brazil |

⁷

Departamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense, Niterói, RJ, CEP, 24210-201, Brazil |

⁸

Programas de Pós-graduação em Biotecnologia Marinha e de Neurologia, Universidade Federal Fluminense, Niterói, RJ, Brazil |

Publication type: Journal Article

Publication date: 2023-09-01

Taylor & Francis

Future Virology

scimago Q3

wos Q4

SJR: 0.361

CiteScore: 3.5

Impact factor: 1.4

ISSN: 17460794, 17460808

DOI: 10.2217/fvl-2023-0142

Copy DOI

PubMed ID: 37974899

Virology

Abstract

Aim: This work aimed to investigate the antiviral activity of two 1,4-disubstituted-1,2,3-triazole derivatives (1 and 2) against Chikungunya virus (CHIKV) replication. Materials & methods: Cytotoxicity was analyzed using colorimetric assays and the antiviral potential was evaluated using plaque assays and computational tools. Results: Compound 2 showed antiviral activity against CHIKV 181-25 in BHK-21 and Vero cells. Also, this compound presented a higher activity against CHIKV BRA/RJ/18 in Vero cells, like compound 1. Compound 2 exhibited virucidal activity and inhibited virus entry while compound 1 inhibited virus release. Molecular docking suggested that these derivatives inhibit nsP1 protein while compound 1 may also target capsid protein. Conclusion: Both compounds exhibit promising antiviral activity against CHIKV by blocking different steps of virus replication.

Found

1 citation

Larina Lyudmula

56 publications, 361 citations, 2 reviews

h-index: 10

A.E. Favorsky Irkutsk Institute of Chemistry of the Siberian Branch of the Russian Academy of Sciences

Photochemistry Center

Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences

Chungnam National University

Top-30

Journals

	1
ACS Omega	ACS Omega, 1, 16.67% ACS Omega 1 publication, 16.67%
Archives of Microbiology	Archives of Microbiology, 1, 16.67% Archives of Microbiology 1 publication, 16.67%
Future Pharmacology	Future Pharmacology, 1, 16.67% Future Pharmacology 1 publication, 16.67%
Russian Chemical Reviews	Russian Chemical Reviews, 1, 16.67% Russian Chemical Reviews 1 publication, 16.67%
Archives of Virology	Archives of Virology, 1, 16.67% Archives of Virology 1 publication, 16.67%
Letters in Applied Microbiology	Letters in Applied Microbiology, 1, 16.67% Letters in Applied Microbiology 1 publication, 16.67%
	1

Publishers

	1 2
Springer Nature	Springer Nature, 2, 33.33% Springer Nature 2 publications, 33.33%
American Chemical Society (ACS)	American Chemical Society (ACS), 1, 16.67% American Chemical Society (ACS) 1 publication, 16.67%
MDPI	MDPI, 1, 16.67% MDPI 1 publication, 16.67%
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii	Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii, 1, 16.67% Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii 1 publication, 16.67%
Oxford University Press	Oxford University Press, 1, 16.67% Oxford University Press 1 publication, 16.67%
	1 2

We do not take into account publications without a DOI.
Statistics recalculated weekly.

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.

Metrics

Cite this

GOST |

Cite this

GOST Copy

Rabelo V. W. H. et al. Antiviral evaluation of 1,4-disubstituted-1,2,3-triazole derivatives against Chikungunya virus // Future Virology. 2023. Vol. 18. No. 13. pp. 865-880.

GOST all authors (up to 50) Copy

Rabelo V. W. H., Da Silva V. D., Sanchez Nuñez M. L., Santos Corrêa Amorim L. D., Buarque C. D., Kuhn R., Abreu P. A., Paixão I. C. Antiviral evaluation of 1,4-disubstituted-1,2,3-triazole derivatives against Chikungunya virus // Future Virology. 2023. Vol. 18. No. 13. pp. 865-880.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.2217/fvl-2023-0142

UR - https://doi.org/10.2217/fvl-2023-0142

TI - Antiviral evaluation of 1,4-disubstituted-1,2,3-triazole derivatives against Chikungunya virus

T2 - Future Virology

AU - Rabelo, Vitor Won Held

AU - Da Silva, Verônica Diniz

AU - Sanchez Nuñez, Maria Leonisa

AU - Santos Corrêa Amorim, Leonardo dos

AU - Buarque, Camilla D

AU - Kuhn, R.

AU - Abreu, Paula Alvarez

AU - Paixão, Izabel C.

PY - 2023

DA - 2023/09/01

PB - Taylor & Francis

SP - 865-880

IS - 13

VL - 18

PMID - 37974899

SN - 1746-0794

SN - 1746-0808

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2023_Rabelo,

author = {Vitor Won Held Rabelo and Verônica Diniz Da Silva and Maria Leonisa Sanchez Nuñez and Leonardo dos Santos Corrêa Amorim and Camilla D Buarque and R. Kuhn and Paula Alvarez Abreu and Izabel C. Paixão},

title = {Antiviral evaluation of 1,4-disubstituted-1,2,3-triazole derivatives against Chikungunya virus},

journal = {Future Virology},

year = {2023},

volume = {18},

publisher = {Taylor & Francis},

month = {sep},

url = {https://doi.org/10.2217/fvl-2023-0142},

number = {13},

pages = {865--880},

doi = {10.2217/fvl-2023-0142}

}

MLA

Cite this

MLA Copy

Rabelo, Vitor Won Held, et al. “Antiviral evaluation of 1,4-disubstituted-1,2,3-triazole derivatives against Chikungunya virus.” Future Virology, vol. 18, no. 13, Sep. 2023, pp. 865-880. https://doi.org/10.2217/fvl-2023-0142.

Publisher

Taylor & Francis

Journal

Future Virology

scimago Q3

wos Q4

SJR

0.361

CiteScore

3.5

Impact factor

1.4

ISSN

17460794 (Print)

17460808 (Electronic)