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Open access
National Library of Serbia
Journal of the Serbian Chemical Society
,  volume 71 ,  issue 5 ,  pages 471-481

Pyrazine-2-substituted carboxamide derivatives: synthesis, antimicrobial and leuconostoc mesenteroides growth inhibition activity

Abd El-Wahab 1
, 
A.H. Bedair 1
, 
F.A. Eid 1
, 
A.F. El-Haddad 1
, 
Adawy El-Deeb 2
, 
G.M. El-Sherbiny 3
1
 
2
 
Department of Research and Development Affairs Sugar & Intergrated Industries Companies, El-Hwamdia, Giza | 
3
 
Publication type: Journal Article
Publication date: 2006-10-10
National Library of Serbia
scimago Q3
wos Q4
SJR: 0.228
CiteScore: 1.8
Impact factor: 0.7
ISSN: 03525139, 18207421
General Chemistry
Abstract

Condensation of pyrazine-2,3-dicarboxylic acid anhydride with aminoacetophenones gave the corresponding N-(acetylphenyl)pyrazine-2-carboxamide. Their reactions with some electrophilic (carbonyl group, bromine) and nucleophilic (malononitrile hydrazine) reagents are discussed. N-[3-(2,2-Dicyano-1-methylethenyl)phenyl]pyrazine- 2-carboxamide underwent Michael addition reaction with an activated double bond yielding 3-amino-5-aryl-3?-(pyrazine-2-carboxamido)biphenyl-2,4-dicarbonitrile derivatives and 2-imino-4-(3-(pyrazine-2-carboxamido)phenyl)-6-(4-methoxyphenyl)cyclohexa 3,5-diene-1,1,3-tricarbonitrile. The structures of the newly synthesized compounds were confirmed by their IR, 1H NMR, 13C NMR and mass spectra data. Antimicrobial acitivites and Leuconostoc sp. growth inhibition of the newly synthesized compounds were studied and some of these were found to exhibit a pronounced effect.

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GOST Copy
El-Wahab A. et al. Pyrazine-2-substituted carboxamide derivatives: synthesis, antimicrobial and leuconostoc mesenteroides growth inhibition activity // Journal of the Serbian Chemical Society. 2006. Vol. 71. No. 5. pp. 471-481.
GOST all authors (up to 50) Copy
El-Wahab A., Bedair A., Eid F., El-Haddad A., El-Deeb A., El-Sherbiny G. Pyrazine-2-substituted carboxamide derivatives: synthesis, antimicrobial and leuconostoc mesenteroides growth inhibition activity // Journal of the Serbian Chemical Society. 2006. Vol. 71. No. 5. pp. 471-481.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.2298/jsc0605471e
UR - https://doi.org/10.2298/jsc0605471e
TI - Pyrazine-2-substituted carboxamide derivatives: synthesis, antimicrobial and leuconostoc mesenteroides growth inhibition activity
T2 - Journal of the Serbian Chemical Society
AU - El-Wahab, Abd
AU - Bedair, A.H.
AU - Eid, F.A.
AU - El-Haddad, A.F.
AU - El-Deeb, Adawy
AU - El-Sherbiny, G.M.
PY - 2006
DA - 2006/10/10
PB - National Library of Serbia
SP - 471-481
IS - 5
VL - 71
SN - 0352-5139
SN - 1820-7421
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2006_El-Wahab,
author = {Abd El-Wahab and A.H. Bedair and F.A. Eid and A.F. El-Haddad and Adawy El-Deeb and G.M. El-Sherbiny},
title = {Pyrazine-2-substituted carboxamide derivatives: synthesis, antimicrobial and leuconostoc mesenteroides growth inhibition activity},
journal = {Journal of the Serbian Chemical Society},
year = {2006},
volume = {71},
publisher = {National Library of Serbia},
month = {oct},
url = {https://doi.org/10.2298/jsc0605471e},
number = {5},
pages = {471--481},
doi = {10.2298/jsc0605471e}
}
MLA
Cite this
MLA Copy
El-Wahab, Abd, et al. “Pyrazine-2-substituted carboxamide derivatives: synthesis, antimicrobial and leuconostoc mesenteroides growth inhibition activity.” Journal of the Serbian Chemical Society, vol. 71, no. 5, Oct. 2006, pp. 471-481. https://doi.org/10.2298/jsc0605471e.