Diabetes, volume 64, issue 12, pages 4088-4098

The Metabolic Regulator Histone Deacetylase 9 Contributes to Glucose Homeostasis Abnormality Induced by Hepatitis C Virus Infection

Chen Jizheng ¹

Wang Ning ²

Dong Mei ²

Guo Min ¹

Zhao Yang ³

Zhuo Zhiyong ³

Zhang Chao ³

Chi Xiumei ⁴

Pan Yu ⁴

Jiang Jing ⁴

Tang Hong ¹

Niu Junqi ⁴

Yang Dongliang ⁵

Li Zhong ²

Han Xiao ²

Wang Qian ²

Chen Xinwen ¹

Hide authors affiliations Show authors affiliations: 5 affiliations

State key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China |

Jiangsu Province Key Laboratory of Human Functional Genomics, Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, China |

Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China |

⁴

Department of Hepatology, the First Hospital of Jilin University, Changchun, China |

⁵

Department of Infectious Diseases, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China |

Publication type: Journal Article

Publication date: 2015-09-29

American Diabetes Association

Journal: Diabetes

Quartile SCImago

Quartile WOS

Impact factor: 7.7

ISSN: 00121797, 23724765

DOI: 10.2337/db15-0197

Copy DOI

Endocrinology, Diabetes and Metabolism

Internal Medicine

Abstract

Class IIa histone deacetylases (HDACs), such as HDAC4, HDAC5, and HDAC7, provide critical mechanisms for regulating glucose homeostasis. Here we report that HDAC9, another class IIa HDAC, regulates hepatic gluconeogenesis via deacetylation of a Forkhead box O (FoxO) family transcription factor, FoxO1, together with HDAC3. Specifically, HDAC9 expression can be strongly induced upon hepatitis C virus (HCV) infection. HCV-induced HDAC9 upregulation enhances gluconeogenesis by promoting the expression of gluconeogenic genes, including phosphoenolpyruvate carboxykinase and glucose-6-phosphatase, indicating a major role for HDAC9 in the development of HCV-associated exaggerated gluconeogenic responses. Moreover, HDAC9 expression levels and gluconeogenic activities were elevated in livers from HCV-infected patients and persistent HCV-infected mice, emphasizing the clinical relevance of these results. Our results suggest HDAC9 is involved in glucose metabolism, HCV-induced abnormal glucose homeostasis, and type 2 diabetes.

By date By citations

Citations by journals

	1 2
Cells	Cells, 2, 5.13% Cells 2 publications, 5.13%
European Journal of Medicinal Chemistry	European Journal of Medicinal Chemistry, 1, 2.56% European Journal of Medicinal Chemistry 1 publication, 2.56%
Bioorganic and Medicinal Chemistry Letters	Bioorganic and Medicinal Chemistry Letters, 1, 2.56% Bioorganic and Medicinal Chemistry Letters 1 publication, 2.56%
Oncotarget	Oncotarget, 1, 2.56% Oncotarget 1 publication, 2.56%
Bioscience Reports	Bioscience Reports, 1, 2.56% Bioscience Reports 1 publication, 2.56%
Clinical Science	Clinical Science, 1, 2.56% Clinical Science 1 publication, 2.56%
Circulation Research	Circulation Research, 1, 2.56% Circulation Research 1 publication, 2.56%
Bioinformatics and Biology Insights	Bioinformatics and Biology Insights, 1, 2.56% Bioinformatics and Biology Insights 1 publication, 2.56%
Life	Life, 1, 2.56% Life 1 publication, 2.56%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 1, 2.56% International Journal of Molecular Sciences 1 publication, 2.56%
Cellular oncology (Dordrecht)	Cellular oncology (Dordrecht), 1, 2.56% Cellular oncology (Dordrecht) 1 publication, 2.56%
Scientific Reports	Scientific Reports, 1, 2.56% Scientific Reports 1 publication, 2.56%
Nature Communications	Nature Communications, 1, 2.56% Nature Communications 1 publication, 2.56%
Protein and Cell	Protein and Cell, 1, 2.56% Protein and Cell 1 publication, 2.56%
Nutrition Clinique et Metabolisme	Nutrition Clinique et Metabolisme, 1, 2.56% Nutrition Clinique et Metabolisme 1 publication, 2.56%
PLoS ONE	PLoS ONE, 1, 2.56% PLoS ONE 1 publication, 2.56%
Metabolism: Clinical and Experimental	Metabolism: Clinical and Experimental, 1, 2.56% Metabolism: Clinical and Experimental 1 publication, 2.56%
Biochimie	Biochimie, 1, 2.56% Biochimie 1 publication, 2.56%
Food and Chemical Toxicology	Food and Chemical Toxicology, 1, 2.56% Food and Chemical Toxicology 1 publication, 2.56%
Chemico-Biological Interactions	Chemico-Biological Interactions, 1, 2.56% Chemico-Biological Interactions 1 publication, 2.56%
Pharmacological Research	Pharmacological Research, 1, 2.56% Pharmacological Research 1 publication, 2.56%
Journal of Biological Chemistry	Journal of Biological Chemistry, 1, 2.56% Journal of Biological Chemistry 1 publication, 2.56%
Virologica Sinica	Virologica Sinica, 1, 2.56% Virologica Sinica 1 publication, 2.56%
Journal of Pineal Research	Journal of Pineal Research, 1, 2.56% Journal of Pineal Research 1 publication, 2.56%
Journal of Cellular Physiology	Journal of Cellular Physiology, 1, 2.56% Journal of Cellular Physiology 1 publication, 2.56%
European Journal of Immunology	European Journal of Immunology, 1, 2.56% European Journal of Immunology 1 publication, 2.56%
Cell Cycle	Cell Cycle, 1, 2.56% Cell Cycle 1 publication, 2.56%
Epigenetics	Epigenetics, 1, 2.56% Epigenetics 1 publication, 2.56%
Journal of Molecular Cell Biology	Journal of Molecular Cell Biology, 1, 2.56% Journal of Molecular Cell Biology 1 publication, 2.56%

	1 2

Citations by publishers

	1 2 3 4 5 6 7 8 9
Elsevier	Elsevier, 9, 23.08% Elsevier 9 publications, 23.08%
Springer Nature	Springer Nature, 5, 12.82% Springer Nature 5 publications, 12.82%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 5, 12.82% Multidisciplinary Digital Publishing Institute (MDPI) 5 publications, 12.82%
Wiley	Wiley, 3, 7.69% Wiley 3 publications, 7.69%
Taylor & Francis	Taylor & Francis, 2, 5.13% Taylor & Francis 2 publications, 5.13%
Oxford University Press	Oxford University Press, 2, 5.13% Oxford University Press 2 publications, 5.13%
Impact Journals	Impact Journals, 1, 2.56% Impact Journals 1 publication, 2.56%
Portland Press	Portland Press, 1, 2.56% Portland Press 1 publication, 2.56%
Wolters Kluwer Health	Wolters Kluwer Health, 1, 2.56% Wolters Kluwer Health 1 publication, 2.56%
SAGE	SAGE, 1, 2.56% SAGE 1 publication, 2.56%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 1, 2.56% Public Library of Science (PLoS) 1 publication, 2.56%
American Society for Biochemistry and Molecular Biology	American Society for Biochemistry and Molecular Biology, 1, 2.56% American Society for Biochemistry and Molecular Biology 1 publication, 2.56%
KeAi Communications Co.	KeAi Communications Co., 1, 2.56% KeAi Communications Co. 1 publication, 2.56%
Korean Diabetes Association	Korean Diabetes Association, 1, 2.56% Korean Diabetes Association 1 publication, 2.56%
Bentham Science	Bentham Science, 1, 2.56% Bentham Science 1 publication, 2.56%
	1 2 3 4 5 6 7 8 9

We do not take into account publications that without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2016,2017,2018,2019,2020,2021,2022,2023,2024],"ids":[0,0,0,0,0,0,0,0,0],"codes":[0,0,0,0,0,0,0,0,0],"imageUrls":["","","","","","","","",""],"datasets":[{"label":"Citations number","data":[6,6,4,6,5,6,1,1,4],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["15.38","15.38","10.26","15.38","12.82","15.38","2.56","2.56","10.26"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Cells","European Journal of Medicinal Chemistry","Bioorganic and Medicinal Chemistry Letters","Oncotarget","Bioscience Reports","Clinical Science","Circulation Research","Bioinformatics and Biology Insights","Life","International Journal of Molecular Sciences","Cellular oncology (Dordrecht)","Scientific Reports","Nature Communications","Protein and Cell","Nutrition Clinique et Metabolisme","PLoS ONE","Metabolism: Clinical and Experimental","Biochimie","Food and Chemical Toxicology","Chemico-Biological Interactions","Pharmacological Research","Journal of Biological Chemistry","Virologica Sinica","Journal of Pineal Research","Journal of Cellular Physiology","European Journal of Immunology","Cell Cycle","Epigenetics","Journal of Molecular Cell Biology"],"ids":[25293,8171,8828,8484,2803,2028,9462,5782,23944,14627,11996,13767,3231,1317,3920,24963,18555,4794,8445,15240,4321,19451,15137,13951,4815,5848,16553,2583,9902],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/HY0CXgRt044tzIAB16PDvDzdHeKHGtSvlMH0yWf6_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/nUqNrP9GnM1t0BrAIXp1LBodjU8aIJ2Fk4pLfGhZ_medium.webp","\/storage\/images\/resized\/6QE8LXWrLpkoy5A2te6hw7who46GeCoTYIstuoAz_medium.webp","\/storage\/images\/resized\/ruydfaB80LDjlkYqsfOeUAZohOIODyq7bQzis5O7_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/OuA6WPZekwEiUM99mP2pSqj4yHPxHezM6xgLhAjO_medium.webp","\/storage\/images\/resized\/jeWDR7NTA9Ab5MVz8Uqjl2RPCndzFjSyl0FaRAHg_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/yNSijlgQghQF53VZuyFLA30CKDe4j3HK74Vtpnxa_medium.webp"],"datasets":[{"label":"","data":[2,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[5.13,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Elsevier","Springer Nature","Multidisciplinary Digital Publishing Institute (MDPI)","Wiley","Taylor & Francis","Oxford University Press","Impact Journals","Portland Press","Wolters Kluwer Health","SAGE","Public Library of Science (PLoS)","American Society for Biochemistry and Molecular Biology","KeAi Communications Co.","Korean Diabetes Association","Bentham Science"],"ids":[17,8,202,11,18,19,342,801,32,31,344,2090,326,5361,39],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/yNSijlgQghQF53VZuyFLA30CKDe4j3HK74Vtpnxa_medium.webp","\/storage\/images\/resized\/HY0CXgRt044tzIAB16PDvDzdHeKHGtSvlMH0yWf6_medium.webp","\/storage\/images\/resized\/nUqNrP9GnM1t0BrAIXp1LBodjU8aIJ2Fk4pLfGhZ_medium.webp","\/storage\/images\/resized\/6QE8LXWrLpkoy5A2te6hw7who46GeCoTYIstuoAz_medium.webp","\/storage\/images\/resized\/ruydfaB80LDjlkYqsfOeUAZohOIODyq7bQzis5O7_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp","\/storage\/images\/resized\/OuA6WPZekwEiUM99mP2pSqj4yHPxHezM6xgLhAjO_medium.webp","\/storage\/images\/resized\/jeWDR7NTA9Ab5MVz8Uqjl2RPCndzFjSyl0FaRAHg_medium.webp","","\/storage\/images\/resized\/doUaFUZdxUEQjLi1TwZjGHi8HXYNWWSk04dSC6Xh_medium.webp"],"datasets":[{"label":"","data":[9,5,5,3,2,2,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[23.08,12.82,12.82,7.69,5.13,5.13,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}

Metrics

Cite this

GOST |

Cite this

GOST Copy

Chen J. et al. The Metabolic Regulator Histone Deacetylase 9 Contributes to Glucose Homeostasis Abnormality Induced by Hepatitis C Virus Infection // Diabetes. 2015. Vol. 64. No. 12. pp. 4088-4098.

GOST all authors (up to 50) Copy

Chen J., Wang N., Dong M., Guo M., Zhao Yang, Zhuo Z., Zhang C., Chi X., Pan Yu., Jiang J., Tang H., Niu J., Yang D., Li Zhong, Han X., Wang Q., Chen X. The Metabolic Regulator Histone Deacetylase 9 Contributes to Glucose Homeostasis Abnormality Induced by Hepatitis C Virus Infection // Diabetes. 2015. Vol. 64. No. 12. pp. 4088-4098.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.2337/db15-0197

UR - https://doi.org/10.2337%2Fdb15-0197

TI - The Metabolic Regulator Histone Deacetylase 9 Contributes to Glucose Homeostasis Abnormality Induced by Hepatitis C Virus Infection

T2 - Diabetes

AU - Chen, Jizheng

AU - Wang, Ning

AU - Dong, Mei

AU - Guo, Min

AU - Zhao Yang

AU - Zhuo, Zhiyong

AU - Zhang, Chao

AU - Chi, Xiumei

AU - Pan, Yu

AU - Jiang, Jing

AU - Tang, Hong

AU - Niu, Junqi

AU - Yang, Dongliang

AU - Li Zhong

AU - Han, Xiao

AU - Wang, Qian

AU - Chen, Xinwen

PY - 2015

DA - 2015/09/29 00:00:00

PB - American Diabetes Association

SP - 4088-4098

IS - 12

VL - 64

SN - 0012-1797

SN - 2372-4765

ER -

BibTex |

Cite this

BibTex Copy

@article{2015_Chen,

author = {Jizheng Chen and Ning Wang and Mei Dong and Min Guo and Zhao Yang and Zhiyong Zhuo and Chao Zhang and Xiumei Chi and Yu Pan and Jing Jiang and Hong Tang and Junqi Niu and Dongliang Yang and Li Zhong and Xiao Han and Qian Wang and Xinwen Chen},

title = {The Metabolic Regulator Histone Deacetylase 9 Contributes to Glucose Homeostasis Abnormality Induced by Hepatitis C Virus Infection},

journal = {Diabetes},

year = {2015},

volume = {64},

publisher = {American Diabetes Association},

month = {sep},

url = {https://doi.org/10.2337%2Fdb15-0197},

number = {12},

pages = {4088--4098},

doi = {10.2337/db15-0197}

}

MLA

Cite this

MLA Copy

Chen, Jizheng, et al. “The Metabolic Regulator Histone Deacetylase 9 Contributes to Glucose Homeostasis Abnormality Induced by Hepatitis C Virus Infection.” Diabetes, vol. 64, no. 12, Sep. 2015, pp. 4088-4098. https://doi.org/10.2337%2Fdb15-0197.

Found error?

Publisher

American Diabetes Association

Journal

Diabetes

Quartile SCImago

Quartile WOS

Impact factor

7.7

ISSN

00121797 (Print)
23724765 (Electronic)