Open Access
Duration of infectiousness and correlation with RT-PCR cycle threshold values in cases of COVID-19, England, January to May 2020
Anika Singanayagam
1, 2
,
Monika Patel
1, 2
,
Andre Charlett
3
,
Jamie Lopez Bernal
4
,
Vanessa Saliba
4
,
Joanna Ellis
2
,
Shamez Ladhani
4
,
Maria Zambon
2
,
Robin Gopal
2
1
These authors contributed equally
2
Virus Reference Department, Public Health England, Colindale, United Kingdom
|
3
Data and Analytical Services, Public Health England, Colindale, United Kingdom
|
4
Immunisation and Countermeasures, Public Health England, Colindale, United Kingdom
|
Publication type: Journal Article
Publication date: 2020-08-13
scimago Q1
wos Q1
SJR: 2.331
CiteScore: 15.5
Impact factor: 7.8
ISSN: 15607917, 1025496X
PubMed ID:
32794447
Public Health, Environmental and Occupational Health
Epidemiology
Virology
Abstract
Severe acute respiratory syndrome coronavirus 2 viral load in the upper respiratory tract peaks around symptom onset and infectious virus persists for 10 days in mild-to-moderate coronavirus disease (n = 324 samples analysed). RT-PCR cycle threshold (Ct) values correlate strongly with cultivable virus. Probability of culturing virus declines to 8% in samples with Ct > 35 and to 6% 10 days after onset; it is similar in asymptomatic and symptomatic persons. Asymptomatic persons represent a source of transmissible virus.
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Total citations:
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Citations from 2024:
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Singanayagam A. et al. Duration of infectiousness and correlation with RT-PCR cycle threshold values in cases of COVID-19, England, January to May 2020 // Eurosurveillance. 2020. Vol. 25. No. 32.
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Singanayagam A., Patel M., Charlett A., Lopez Bernal J., Saliba V., Ellis J., Ladhani S., Zambon M., Gopal R. Duration of infectiousness and correlation with RT-PCR cycle threshold values in cases of COVID-19, England, January to May 2020 // Eurosurveillance. 2020. Vol. 25. No. 32.
Cite this
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TY - JOUR
DO - 10.2807/1560-7917.ES.2020.25.32.2001483
UR - https://doi.org/10.2807/1560-7917.ES.2020.25.32.2001483
TI - Duration of infectiousness and correlation with RT-PCR cycle threshold values in cases of COVID-19, England, January to May 2020
T2 - Eurosurveillance
AU - Singanayagam, Anika
AU - Patel, Monika
AU - Charlett, Andre
AU - Lopez Bernal, Jamie
AU - Saliba, Vanessa
AU - Ellis, Joanna
AU - Ladhani, Shamez
AU - Zambon, Maria
AU - Gopal, Robin
PY - 2020
DA - 2020/08/13
PB - European Centre for Disease Control and Prevention (ECDC)
IS - 32
VL - 25
PMID - 32794447
SN - 1560-7917
SN - 1025-496X
ER -
Cite this
BibTex (up to 50 authors)
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@article{2020_Singanayagam,
author = {Anika Singanayagam and Monika Patel and Andre Charlett and Jamie Lopez Bernal and Vanessa Saliba and Joanna Ellis and Shamez Ladhani and Maria Zambon and Robin Gopal},
title = {Duration of infectiousness and correlation with RT-PCR cycle threshold values in cases of COVID-19, England, January to May 2020},
journal = {Eurosurveillance},
year = {2020},
volume = {25},
publisher = {European Centre for Disease Control and Prevention (ECDC)},
month = {aug},
url = {https://doi.org/10.2807/1560-7917.ES.2020.25.32.2001483},
number = {32},
doi = {10.2807/1560-7917.ES.2020.25.32.2001483}
}