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Düzce Üniversitesi Bilim ve Teknoloji Dergisi
,  volume 10 ,  issue 1 ,  pages 14-26

Synthesis and Biological Evaluation of Imidazole-2-thione Fused Furazan as a New Biheterocyclic Scaffold

Gulsah Kurt 1
, 
Fatih Sevgi 2
1
 
AKSARAY ÜNİVERSİTESİ | 
2
 
SELÇUK ÜNİVERSİTESİ
Publication type: Journal Article
Publication date: 2022-01-31
SJR: —
CiteScore: —
Impact factor: —
ISSN: 21482446
Abstract
A new imidazole-2-thione fused furazan biheterocyclic group was synthesized and its biological activity was investigated. Nitrogen rich heterocycles, imidazole-2-thione and 1,2,5-oxadiazole (furazan) have been conveni ently fused. To accomplish this, we have improved a new strategy that silica gel supported solvent free micro wave dehydration of vicinal dioximes. The target furazan "N,N’-diphenyl-4H-imidazo[4,5-c]furazan-5(6H) –thio ne" [II] (DFTFrz) was obtained from (4E,5Z)-4,5-bis(hydroxyimino)-N,N’-diphenylimidazolidine-2-thione [I] (DFTD) with acceptable yield and characterized by LC-MS/MS, FT-IR and NMR spectroscopy. The biological evaluation of the obtained thiourea furazan and its precursor dioxime were investigated by antibacterial effect studies using broth microdilution and disc diffusion methods. It was observed that thioure furazan was more effective on the tested pathogenic bacteria than its precursor dioxime. The compounds did not show any effect on gram negative bacteria, while they exhibited a moderate effect on gram positive bacteria, especially Staphylococcus spp.
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Kurt G., Sevgi F. Synthesis and Biological Evaluation of Imidazole-2-thione Fused Furazan as a New Biheterocyclic Scaffold // Düzce Üniversitesi Bilim ve Teknoloji Dergisi. 2022. Vol. 10. No. 1. pp. 14-26.
GOST all authors (up to 50) Copy
Kurt G., Sevgi F. Synthesis and Biological Evaluation of Imidazole-2-thione Fused Furazan as a New Biheterocyclic Scaffold // Düzce Üniversitesi Bilim ve Teknoloji Dergisi. 2022. Vol. 10. No. 1. pp. 14-26.
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TY - JOUR
DO - 10.29130/dubited.880667
UR - http://dergipark.org.tr/en/doi/10.29130/dubited.880667
TI - Synthesis and Biological Evaluation of Imidazole-2-thione Fused Furazan as a New Biheterocyclic Scaffold
T2 - Düzce Üniversitesi Bilim ve Teknoloji Dergisi
AU - Kurt, Gulsah
AU - Sevgi, Fatih
PY - 2022
DA - 2022/01/31
PB - Duzce Universitesi Bilim ve Teknoloji Dergisi
SP - 14-26
IS - 1
VL - 10
SN - 2148-2446
ER -
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@article{2022_Kurt,
author = {Gulsah Kurt and Fatih Sevgi},
title = {Synthesis and Biological Evaluation of Imidazole-2-thione Fused Furazan as a New Biheterocyclic Scaffold},
journal = {Düzce Üniversitesi Bilim ve Teknoloji Dergisi},
year = {2022},
volume = {10},
publisher = {Duzce Universitesi Bilim ve Teknoloji Dergisi},
month = {jan},
url = {http://dergipark.org.tr/en/doi/10.29130/dubited.880667},
number = {1},
pages = {14--26},
doi = {10.29130/dubited.880667}
}
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Kurt, Gulsah, and Fatih Sevgi. “Synthesis and Biological Evaluation of Imidazole-2-thione Fused Furazan as a New Biheterocyclic Scaffold.” Düzce Üniversitesi Bilim ve Teknoloji Dergisi, vol. 10, no. 1, Jan. 2022, pp. 14-26. http://dergipark.org.tr/en/doi/10.29130/dubited.880667.