Calcium phosphate particles containing superoxide dismutase are a promising agent for the treatment of eye diseases accompanied by oxidative stress
Publication type: Journal Article
Publication date: 2016-05-01
scimago Q4
wos Q4
SJR: 0.153
CiteScore: 1.1
Impact factor: 0.5
ISSN: 00271314, 19350260
General Chemistry
Abstract
A method for the preparation of calcium phosphate particles is optimized. Particles with entrapped superoxide dismutase are obtained. The size, surface charge, and stability of the calcium phosphate particles are determined under different conditions. The kinetics of the enzyme release from the particles and the influence of the drug release on the size and surface charge of the particles are investigated. On the rabbit model of immunogenic uveitis (the model of an inflammatory process in the eye accompanied by oxidative stress), it is shown that superoxide dismutase enclosed in calcium phosphate particles has a higher antiinflammatory effect than superoxide dismutase in an aqueous solution.
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Nikol'skaya I. I. et al. Calcium phosphate particles containing superoxide dismutase are a promising agent for the treatment of eye diseases accompanied by oxidative stress // Moscow University Chemistry Bulletin. 2016. Vol. 71. No. 3. pp. 154-159.
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Nikol'skaya I. I., Beznos O. V., Galitskiy V. A., Chesnokova N. B., Kost O. A. Calcium phosphate particles containing superoxide dismutase are a promising agent for the treatment of eye diseases accompanied by oxidative stress // Moscow University Chemistry Bulletin. 2016. Vol. 71. No. 3. pp. 154-159.
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RIS
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TY - JOUR
DO - 10.3103/s002713141603007x
UR - https://doi.org/10.3103/s002713141603007x
TI - Calcium phosphate particles containing superoxide dismutase are a promising agent for the treatment of eye diseases accompanied by oxidative stress
T2 - Moscow University Chemistry Bulletin
AU - Nikol'skaya, I. I.
AU - Beznos, O V
AU - Galitskiy, V A
AU - Chesnokova, N B
AU - Kost, O A
PY - 2016
DA - 2016/05/01
PB - Pleiades Publishing
SP - 154-159
IS - 3
VL - 71
SN - 0027-1314
SN - 1935-0260
ER -
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@article{2016_Nikol'skaya,
author = {I. I. Nikol'skaya and O V Beznos and V A Galitskiy and N B Chesnokova and O A Kost},
title = {Calcium phosphate particles containing superoxide dismutase are a promising agent for the treatment of eye diseases accompanied by oxidative stress},
journal = {Moscow University Chemistry Bulletin},
year = {2016},
volume = {71},
publisher = {Pleiades Publishing},
month = {may},
url = {https://doi.org/10.3103/s002713141603007x},
number = {3},
pages = {154--159},
doi = {10.3103/s002713141603007x}
}
Cite this
MLA
Copy
Nikol'skaya, I. I., et al. “Calcium phosphate particles containing superoxide dismutase are a promising agent for the treatment of eye diseases accompanied by oxidative stress.” Moscow University Chemistry Bulletin, vol. 71, no. 3, May. 2016, pp. 154-159. https://doi.org/10.3103/s002713141603007x.