The Inclusion of Timolol and Lisinopril in Calcium Phosphate Particles Covered by Chitosan: Application in Ophthalmology
I. I. Nikol'skaya
1
,
O V Beznos
2
,
A.I Eltsov
1
,
I V Gachok
1
,
N B Chesnokova
2
,
V. P. Varlamov
3
,
O A Kost
1
Publication type: Journal Article
Publication date: 2018-03-01
scimago Q4
wos Q4
SJR: 0.153
CiteScore: 1.1
Impact factor: 0.5
ISSN: 00271314, 19350260
General Chemistry
Abstract
Chitosan-covered calcium phosphate nanoparticles with the mean dynamic radii of 30 to 130 nm and ζ-potential of +22 ± 4 mV containing timolol and lisinopril are prepared and characterized. These particles are formed by the amorphous phase represented by amorphous calcium phosphate Ca x (PO4) y · zH2O and the crystalline phase represented by hydrated calcium hydrophoshate (brushite) CaHPO4 · 2H2O. The experiments in vivo demonstrated that the inclusion of timolol into calcium phosphate particles covered with chitosan substantially prolonged its effect on the intraocular pressure.
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Nikol'skaya I. I. et al. The Inclusion of Timolol and Lisinopril in Calcium Phosphate Particles Covered by Chitosan: Application in Ophthalmology // Moscow University Chemistry Bulletin. 2018. Vol. 73. No. 2. pp. 85-89.
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Nikol'skaya I. I., Beznos O. V., Eltsov A., Gachok I. V., Chesnokova N. B., Varlamov V. P., Kost O. A. The Inclusion of Timolol and Lisinopril in Calcium Phosphate Particles Covered by Chitosan: Application in Ophthalmology // Moscow University Chemistry Bulletin. 2018. Vol. 73. No. 2. pp. 85-89.
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RIS
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TY - JOUR
DO - 10.3103/S0027131418020116
UR - https://doi.org/10.3103/S0027131418020116
TI - The Inclusion of Timolol and Lisinopril in Calcium Phosphate Particles Covered by Chitosan: Application in Ophthalmology
T2 - Moscow University Chemistry Bulletin
AU - Nikol'skaya, I. I.
AU - Beznos, O V
AU - Eltsov, A.I
AU - Gachok, I V
AU - Chesnokova, N B
AU - Varlamov, V. P.
AU - Kost, O A
PY - 2018
DA - 2018/03/01
PB - Pleiades Publishing
SP - 85-89
IS - 2
VL - 73
SN - 0027-1314
SN - 1935-0260
ER -
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BibTex (up to 50 authors)
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@article{2018_Nikol'skaya,
author = {I. I. Nikol'skaya and O V Beznos and A.I Eltsov and I V Gachok and N B Chesnokova and V. P. Varlamov and O A Kost},
title = {The Inclusion of Timolol and Lisinopril in Calcium Phosphate Particles Covered by Chitosan: Application in Ophthalmology},
journal = {Moscow University Chemistry Bulletin},
year = {2018},
volume = {73},
publisher = {Pleiades Publishing},
month = {mar},
url = {https://doi.org/10.3103/S0027131418020116},
number = {2},
pages = {85--89},
doi = {10.3103/S0027131418020116}
}
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MLA
Copy
Nikol'skaya, I. I., et al. “The Inclusion of Timolol and Lisinopril in Calcium Phosphate Particles Covered by Chitosan: Application in Ophthalmology.” Moscow University Chemistry Bulletin, vol. 73, no. 2, Mar. 2018, pp. 85-89. https://doi.org/10.3103/S0027131418020116.