Physical and Chemical Properties of the Guest–Host Inclusion Complexes of Cyprofloxacin with β-Cyclodextrin Derivatives
Тип публикации: Journal Article
Дата публикации: 2020-07-01
scimago Q4
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SJR: 0.153
CiteScore: 1.1
Impact factor: 0.5
ISSN: 00271314, 19350260
General Chemistry
Краткое описание
We study the effect of the nature of the substituent in the β-cyclodextrin derivative on the physicochemical properties of the antibacterial drug ciprofloxacin (CF). CF can form guest–host inclusion complexes with β-cyclodextrin derivatives, characterized by dissociation constants (Kdis) in the range of 10–3 to 10–4 M. A ligand with a small polar uncharged substituent (2-hydroxypropyl) form of the most stable complex, which also helps to increase the solubility of CF by 20 and 64% in buffer systems having a pH of 4.0 and 7.4, respectively. The inclusion of CF in a complex with Kdis = 10–3 M or lower contributes to a slower release of the drug. The physicochemical properties of the obtained complexes allow developing a highly effective formulation of the drug.
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Skuredina A. A. et al. Physical and Chemical Properties of the Guest–Host Inclusion Complexes of Cyprofloxacin with β-Cyclodextrin Derivatives // Moscow University Chemistry Bulletin. 2020. Vol. 75. No. 4. pp. 218-224.
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Skuredina A. A., Kopnova T. Yu., Le Deygen I. M., Kudryashova E. V. Physical and Chemical Properties of the Guest–Host Inclusion Complexes of Cyprofloxacin with β-Cyclodextrin Derivatives // Moscow University Chemistry Bulletin. 2020. Vol. 75. No. 4. pp. 218-224.
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TY - JOUR
DO - 10.3103/S0027131420040069
UR - https://doi.org/10.3103/S0027131420040069
TI - Physical and Chemical Properties of the Guest–Host Inclusion Complexes of Cyprofloxacin with β-Cyclodextrin Derivatives
T2 - Moscow University Chemistry Bulletin
AU - Skuredina, A A
AU - Kopnova, T Yu
AU - Le Deygen, I M
AU - Kudryashova, E V
PY - 2020
DA - 2020/07/01
PB - Pleiades Publishing
SP - 218-224
IS - 4
VL - 75
SN - 0027-1314
SN - 1935-0260
ER -
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@article{2020_Skuredina,
author = {A A Skuredina and T Yu Kopnova and I M Le Deygen and E V Kudryashova},
title = {Physical and Chemical Properties of the Guest–Host Inclusion Complexes of Cyprofloxacin with β-Cyclodextrin Derivatives},
journal = {Moscow University Chemistry Bulletin},
year = {2020},
volume = {75},
publisher = {Pleiades Publishing},
month = {jul},
url = {https://doi.org/10.3103/S0027131420040069},
number = {4},
pages = {218--224},
doi = {10.3103/S0027131420040069}
}
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Skuredina, A. A., et al. “Physical and Chemical Properties of the Guest–Host Inclusion Complexes of Cyprofloxacin with β-Cyclodextrin Derivatives.” Moscow University Chemistry Bulletin, vol. 75, no. 4, Jul. 2020, pp. 218-224. https://doi.org/10.3103/S0027131420040069.