Molecular Genetics, Microbiology and Virology, volume 36, issue 4, pages 176-180

Antimicrobial Photodynamic Activity of Hydrophilic Riboflavin Derivatives

Publication typeJournal Article
Publication date2021-10-01
Quartile SCImago
Q4
Quartile WOS
Q4
Impact factor0.5
ISSN08914168, 1934841X
Molecular Biology
Genetics
Microbiology
Infectious Diseases
Virology
Abstract
The aim of this work was to investigate the antibacterial and antiviral properties of a riboflavin derivative (Vitamin B2), flavin mononucleotide and its derivative, synthesized by conjugation with polyethylene glycol (Rf–PEG). Flavin mononucleotide and conjugate of riboflavin with polyethylene glycol were investigated. Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, and Salmonella typhimurium were used as clinical isolates. Due to the growing number of antibiotic-resistant microorganisms, it is necessary to search for new strategies aimed at inactivating pathogens and preventing them from becoming drug-resistant. Antimicrobial photodynamic therapy (aPDT) is a promising approach to inactivate pathogens regardless of their antibiotic resistance status. The work investigated the antibacterial and antiviral properties of the derivative of riboflavin (Vitamin B2), flavin mononucleotide and its derivative synthesized by conjugation with polyethylene glycol (Rf–PEG). It has been shown that hydrophilic riboflavin derivatives are effective photosensitizers and provide inactivation of both gram-positive and -negative microorganisms during aPDT in vitro.

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Multidisciplinary Digital Publishing Institute (MDPI)
Multidisciplinary Digital Publishing Institute (MDPI), 1, 50%
Multidisciplinary Digital Publishing Institute (MDPI)
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Borodina T. N. et al. Antimicrobial Photodynamic Activity of Hydrophilic Riboflavin Derivatives // Molecular Genetics, Microbiology and Virology. 2021. Vol. 36. No. 4. pp. 176-180.
GOST all authors (up to 50) Copy
Borodina T. N., Tolordava E. R., Nikolaeva M. E., Solovev A. I., Romanova Y., Khaydukov E. V., Panchenko V. Ya. Antimicrobial Photodynamic Activity of Hydrophilic Riboflavin Derivatives // Molecular Genetics, Microbiology and Virology. 2021. Vol. 36. No. 4. pp. 176-180.
RIS |
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RIS Copy
TY - JOUR
DO - 10.3103/s0891416821040042
UR - https://doi.org/10.3103%2Fs0891416821040042
TI - Antimicrobial Photodynamic Activity of Hydrophilic Riboflavin Derivatives
T2 - Molecular Genetics, Microbiology and Virology
AU - Borodina, T N
AU - Tolordava, E R
AU - Nikolaeva, M E
AU - Solovev, A I
AU - Romanova, Yulia
AU - Khaydukov, Evgeny V.
AU - Panchenko, V Ya
PY - 2021
DA - 2021/10/01 00:00:00
PB - Pleiades Publishing
SP - 176-180
IS - 4
VL - 36
SN - 0891-4168
SN - 1934-841X
ER -
BibTex |
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BibTex Copy
@article{2021_Borodina
author = {T N Borodina and E R Tolordava and M E Nikolaeva and A I Solovev and Yulia Romanova and Evgeny V. Khaydukov and V Ya Panchenko},
title = {Antimicrobial Photodynamic Activity of Hydrophilic Riboflavin Derivatives},
journal = {Molecular Genetics, Microbiology and Virology},
year = {2021},
volume = {36},
publisher = {Pleiades Publishing},
month = {oct},
url = {https://doi.org/10.3103%2Fs0891416821040042},
number = {4},
pages = {176--180},
doi = {10.3103/s0891416821040042}
}
MLA
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MLA Copy
Borodina, T. N., et al. “Antimicrobial Photodynamic Activity of Hydrophilic Riboflavin Derivatives.” Molecular Genetics, Microbiology and Virology, vol. 36, no. 4, Oct. 2021, pp. 176-180. https://doi.org/10.3103%2Fs0891416821040042.
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