Open Access
Synthesis of Water-Soluble 7-O-Carboxymethyl-Genistein
Zhiling Cao
1
,
Qiao Wu
1
,
Jing Cheng
1
,
Dandan Zhu
1
,
Wengqi Teng
1
,
Weiwei Liu
1
,
Xiaokai Sun
1
,
Guowei Yao
2
Publication type: Journal Article
Publication date: 2017-03-07
scimago Q3
wos Q3
SJR: 0.306
CiteScore: 3.4
Impact factor: 1.2
ISSN: 03082342, 17475198, 20476507
General Chemistry
Abstract
A three-step synthesis from genistein of the water-soluble sodium salt of 7-O-carboxymethyl-genistein is described. Base-catalysed reaction of genistein with t-butyl bromoacetate gave 7-O-(carbo-t-butoxy)methyl-genistein, which was hydrolysed by aqueous acetic acid to 7-O-carboxymethyl-genistein and neutralised (NaHCO3) to give the target compound. The carboxylate group enhanced the water-solubility of genistein more than a thousand-fold and the new derivate will be useful as a candidate compound in pharmacological and clinical chemistry studies of isoflavones.
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Total citations:
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Citations from 2025:
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GOST
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Cao Z. et al. Synthesis of Water-Soluble 7-O-Carboxymethyl-Genistein // Journal of Chemical Research. 2017. Vol. 41. No. 3. pp. 183-185.
GOST all authors (up to 50)
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Cao Z., Wu Q., Cheng J., Zhu D., Teng W., Liu W., Sun X., Yao G. Synthesis of Water-Soluble 7-O-Carboxymethyl-Genistein // Journal of Chemical Research. 2017. Vol. 41. No. 3. pp. 183-185.
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RIS
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TY - JOUR
DO - 10.3184/174751917x14878812592814
UR - https://doi.org/10.3184/174751917x14878812592814
TI - Synthesis of Water-Soluble 7-O-Carboxymethyl-Genistein
T2 - Journal of Chemical Research
AU - Cao, Zhiling
AU - Wu, Qiao
AU - Cheng, Jing
AU - Zhu, Dandan
AU - Teng, Wengqi
AU - Liu, Weiwei
AU - Sun, Xiaokai
AU - Yao, Guowei
PY - 2017
DA - 2017/03/07
PB - SAGE
SP - 183-185
IS - 3
VL - 41
SN - 0308-2342
SN - 1747-5198
SN - 2047-6507
ER -
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BibTex (up to 50 authors)
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@article{2017_Cao,
author = {Zhiling Cao and Qiao Wu and Jing Cheng and Dandan Zhu and Wengqi Teng and Weiwei Liu and Xiaokai Sun and Guowei Yao},
title = {Synthesis of Water-Soluble 7-O-Carboxymethyl-Genistein},
journal = {Journal of Chemical Research},
year = {2017},
volume = {41},
publisher = {SAGE},
month = {mar},
url = {https://doi.org/10.3184/174751917x14878812592814},
number = {3},
pages = {183--185},
doi = {10.3184/174751917x14878812592814}
}
Cite this
MLA
Copy
Cao, Zhiling, et al. “Synthesis of Water-Soluble 7-O-Carboxymethyl-Genistein.” Journal of Chemical Research, vol. 41, no. 3, Mar. 2017, pp. 183-185. https://doi.org/10.3184/174751917x14878812592814.