Open Access
Open access
SAGE
Journal of Chemical Research
,  volume 41 ,  issue 4 ,  pages 239-240

An Efficient Synthesis of 3,5-Dimethoxy-2,4-Difluorobenzoic Acid

Mingguang Zhang 1, 2, 3
, 
Lin Qiu 4
, 
Shuitao Yu 1, 2
, 
Zaixin Chen 1, 2
, 
Shifa Wang 3
1
 
Yabang Medical Research Institute, Changzhou 213145, P.R. China | 
2
 
Jiangsu Novel Quinolone Antibacterial Drugs Engineering Research Center, Changzhou 213145, P.R. China | 
3
 
4
 
Publication type: Journal Article
Publication date: 2017-04-05
SAGE
scimago Q3
wos Q3
SJR: 0.306
CiteScore: 3.4
Impact factor: 1.2
ISSN: 03082342, 17475198, 20476507
General Chemistry
Abstract

3,5-Dimethoxy-2,4-difluorobenzoic acid, as a key intermediate for preparing an impurity of moxifloxacin, was synthesised from 2,3,4,5-tetrafluorobenzoic acid in moderate yield by nitration, methoxyl substitution, reduction of NO2, diazotisation and reduction. The structures of the intermediates and the target compound were identified and determined with IR, NMR and HRMS (ESI).

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GOST |
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GOST Copy
Zhang M. et al. An Efficient Synthesis of 3,5-Dimethoxy-2,4-Difluorobenzoic Acid // Journal of Chemical Research. 2017. Vol. 41. No. 4. pp. 239-240.
GOST all authors (up to 50) Copy
Zhang M., Qiu L., Yu S., Chen Z., Wang S. An Efficient Synthesis of 3,5-Dimethoxy-2,4-Difluorobenzoic Acid // Journal of Chemical Research. 2017. Vol. 41. No. 4. pp. 239-240.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.3184/174751917x14902201357383
UR - https://doi.org/10.3184/174751917x14902201357383
TI - An Efficient Synthesis of 3,5-Dimethoxy-2,4-Difluorobenzoic Acid
T2 - Journal of Chemical Research
AU - Zhang, Mingguang
AU - Qiu, Lin
AU - Yu, Shuitao
AU - Chen, Zaixin
AU - Wang, Shifa
PY - 2017
DA - 2017/04/05
PB - SAGE
SP - 239-240
IS - 4
VL - 41
SN - 0308-2342
SN - 1747-5198
SN - 2047-6507
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2017_Zhang,
author = {Mingguang Zhang and Lin Qiu and Shuitao Yu and Zaixin Chen and Shifa Wang},
title = {An Efficient Synthesis of 3,5-Dimethoxy-2,4-Difluorobenzoic Acid},
journal = {Journal of Chemical Research},
year = {2017},
volume = {41},
publisher = {SAGE},
month = {apr},
url = {https://doi.org/10.3184/174751917x14902201357383},
number = {4},
pages = {239--240},
doi = {10.3184/174751917x14902201357383}
}
MLA
Cite this
MLA Copy
Zhang, Mingguang, et al. “An Efficient Synthesis of 3,5-Dimethoxy-2,4-Difluorobenzoic Acid.” Journal of Chemical Research, vol. 41, no. 4, Apr. 2017, pp. 239-240. https://doi.org/10.3184/174751917x14902201357383.