Binary proton therapy of Ehrlich carcinoma using targeted gold nanoparticles
M V Filimonova
1, 2
,
D.D. Kolmanovich
3, 4
,
G V Tikhonowski
2
,
D S Petrunya
2, 4
,
P A Kotelnikova
5
,
A A Shitova
1
,
O V Soldatova
1
,
A. S. Filimonov
1
,
V A Rybachuk
1
,
A O Kosachenko
1
,
K A Nikolaev
1
,
G A Demyashkin
1
,
A. A. Popov
2
,
M S Savinov
2
,
A.L. Popov
3, 4
,
I V Zelepukin
5
,
A A Lipengolts
2, 6
,
K. E. Shpakova
2, 6
,
A.V. Kabashin
7
,
S N Koryakin
1, 2
,
S. M. Deyev
5
,
I.N. Zavestovskaya
2, 4
1
Publication type: Journal Article
Publication date: 2024-09-15
SJR: —
CiteScore: —
Impact factor: —
ISSN: 26867389
Abstract
Proton therapy can treat tumors located in radiation-sensitive tissues. This article demonstrates the possibility of enhancing the proton therapy with targeted gold nanoparticles that selectively recognize tumor cells. Au-PEG nanoparticles at concentrations above 25 mg/L and 4 Gy proton dose caused complete death of EMT6/P cells in vitro. Binary proton therapy using targeted Au-PEG-FA nanoparticles caused an 80% tumor growth inhibition effect in vivo. The use of targeted gold nanoparticles is promising for enhancing the proton irradiation effect on tumor cells and requires further research to increase the therapeutic index of the approach.
Found
Nothing found, try to update filter.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
0
Total citations:
0
Cite this
GOST |
RIS |
BibTex
Cite this
GOST
Copy
Filimonova M. V. et al. Binary proton therapy of Ehrlich carcinoma using targeted gold nanoparticles // Доклады Российской академии наук Науки о жизни. 2024. Vol. 516. No. 1.
GOST all authors (up to 50)
Copy
Filimonova M. V., Kolmanovich D., Tikhonowski G. V., Petrunya D. S., Kotelnikova P. A., Shitova A. A., Soldatova O. V., Filimonov A. S., Rybachuk V. A., Kosachenko A. O., Nikolaev K. A., Demyashkin G. A., Popov A. A., Savinov M. S., Popov A., Zelepukin I. V., Lipengolts A. A., Shpakova K. E., Kabashin A., Koryakin S. N., Deyev S. M., Zavestovskaya I. Binary proton therapy of Ehrlich carcinoma using targeted gold nanoparticles // Доклады Российской академии наук Науки о жизни. 2024. Vol. 516. No. 1.
Cite this
RIS
Copy
TY - JOUR
DO - 10.31857/s2686738924030104
UR - https://journals.rcsi.science/2686-7389/article/view/263918
TI - Binary proton therapy of Ehrlich carcinoma using targeted gold nanoparticles
T2 - Доклады Российской академии наук Науки о жизни
AU - Filimonova, M V
AU - Kolmanovich, D.D.
AU - Tikhonowski, G V
AU - Petrunya, D S
AU - Kotelnikova, P A
AU - Shitova, A A
AU - Soldatova, O V
AU - Filimonov, A. S.
AU - Rybachuk, V A
AU - Kosachenko, A O
AU - Nikolaev, K A
AU - Demyashkin, G A
AU - Popov, A. A.
AU - Savinov, M S
AU - Popov, A.L.
AU - Zelepukin, I V
AU - Lipengolts, A A
AU - Shpakova, K. E.
AU - Kabashin, A.V.
AU - Koryakin, S N
AU - Deyev, S. M.
AU - Zavestovskaya, I.N.
PY - 2024
DA - 2024/09/15
PB - The Russian Academy of Sciences
IS - 1
VL - 516
SN - 2686-7389
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2024_Filimonova,
author = {M V Filimonova and D.D. Kolmanovich and G V Tikhonowski and D S Petrunya and P A Kotelnikova and A A Shitova and O V Soldatova and A. S. Filimonov and V A Rybachuk and A O Kosachenko and K A Nikolaev and G A Demyashkin and A. A. Popov and M S Savinov and A.L. Popov and I V Zelepukin and A A Lipengolts and K. E. Shpakova and A.V. Kabashin and S N Koryakin and S. M. Deyev and I.N. Zavestovskaya},
title = {Binary proton therapy of Ehrlich carcinoma using targeted gold nanoparticles},
journal = {Доклады Российской академии наук Науки о жизни},
year = {2024},
volume = {516},
publisher = {The Russian Academy of Sciences},
month = {sep},
url = {https://journals.rcsi.science/2686-7389/article/view/263918},
number = {1},
doi = {10.31857/s2686738924030104}
}