Molekulyarnaya Biologiya, volume 56, issue 2, pages 296-319

Analogs of S-Adenosyl-L-Methionine in Studies of Methyltransferases

Publication typeJournal Article
Publication date2022-02-15
Quartile SCImago
Q4
Quartile WOS
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ISSN00268984
General Medicine
Abstract
Methyltransferases (MTases) play an important role in the functioning of living systems, catalyzing the methylation reactions of DNA, RNA, proteins, and small molecules, including endogenous compounds and drugs. Many human diseases are associated with disturbances in the functioning of these enzymes; therefore, the study of MTases is an urgent and important task. Most MTases use the cofactor S-adenosyl-L-methionine (SAM) as a methyl group donor. SAM analogs are widely applicable in the study of MTases: they are used in studies of the catalytic activity of these enzymes, in identification of substrates of new MTases, and for modification of the substrates or substrate linking to MTases. In this review, new synthetic analogs of SAM and the problems that can be solved with their usage are discussed.
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Руденко А. Ю. et al. Analogs of S-Adenosyl-L-Methionine in Studies of Methyltransferases // Molekulyarnaya Biologiya. 2022. Vol. 56. No. 2. pp. 296-319.
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Руденко А. Ю., Марьясина С. С., Сергиев П., Polshakov V. I. Analogs of S-Adenosyl-L-Methionine in Studies of Methyltransferases // Molekulyarnaya Biologiya. 2022. Vol. 56. No. 2. pp. 296-319.
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TY - JOUR
DO - 10.31857/S0026898422020148
UR - https://doi.org/10.31857%2FS0026898422020148
TI - Analogs of S-Adenosyl-L-Methionine in Studies of Methyltransferases
T2 - Molekulyarnaya Biologiya
AU - Руденко, А. Ю.
AU - Марьясина, С. С.
AU - Сергиев, П.В.
AU - Polshakov, Vladimir I.
PY - 2022
DA - 2022/02/15 00:00:00
PB - The Russian Academy of Sciences
SP - 296-319
IS - 2
VL - 56
SN - 0026-8984
ER -
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@article{2022_Руденко
author = {А. Ю. Руденко and С. С. Марьясина and П.В. Сергиев and Vladimir I. Polshakov},
title = {Analogs of S-Adenosyl-L-Methionine in Studies of Methyltransferases},
journal = {Molekulyarnaya Biologiya},
year = {2022},
volume = {56},
publisher = {The Russian Academy of Sciences},
month = {feb},
url = {https://doi.org/10.31857%2FS0026898422020148},
number = {2},
pages = {296--319},
doi = {10.31857/S0026898422020148}
}
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Руденко, А. Ю., et al. “Analogs of S-Adenosyl-L-Methionine in Studies of Methyltransferases.” Molekulyarnaya Biologiya, vol. 56, no. 2, Feb. 2022, pp. 296-319. https://doi.org/10.31857%2FS0026898422020148.
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