Open Access
Emerging Infectious Diseases, volume 27, issue 1, pages 85-91
IgG Seroconversion and Pathophysiology in Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Henry M. Staines
,
Daniela Kirwan
,
David J Clark
,
Emily R. Adams
,
Yolanda Augustin
,
Rachel Byrne
,
Michael Cocozza
,
Luis E. Cuevas
,
Martina Cusinato
,
Benedict M.O. Davies
,
Mark E. Davis
,
P. Davis
,
Annelyse Duvoix
,
Nicholas M. Eckersley
,
Daniel M. Forton
,
Alice J. Fraser
,
Gala Garrod
,
Linda Hadcocks
,
Qinxue Hu
,
Michael Johnson
,
Grant A. Kay
,
Kesja Klekotko
,
Zawditu Lewis
,
Derek Macallan
,
Josephine Mensah-Kane
,
Stefanie Menzies
,
IRENE M. MONAHAN
,
Catherine Porter Moore
,
Gerhard Nebe-von-Caron
,
S. Owen
,
Chris Sainter
,
Amadou A Sall
,
James Schouten
,
Christopher Williams
,
JOHN WILKINS
,
Kevin Woolston
,
Joseph R. Fitchett
,
Sanjeev Krishna
,
Tim Planche
Publication type: Journal Article
Publication date: 2020-12-01
Journal:
Emerging Infectious Diseases
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 11.8
ISSN: 10806040, 10806059
Microbiology (medical)
Infectious Diseases
Epidemiology
Abstract
We investigated the dynamics of seroconversion in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. During March 29-May 22, 2020, we collected serum samples and associated clinical data from 177 persons in London, UK, who had SARS-CoV-2 infection. We measured IgG against SARS-CoV-2 and compared antibody levels with patient outcomes, demographic information, and laboratory characteristics. We found that 2.0%-8.5% of persons did not seroconvert 3-6 weeks after infection. Persons who seroconverted were older, were more likely to have concurrent conditions, and had higher levels of inflammatory markers. Non-White persons had higher antibody concentrations than those who identified as White; these concentrations did not decline during follow-up. Serologic assay results correlated with disease outcome, race, and other risk factors for severe SARS-CoV-2 infection. Serologic assays can be used in surveillance to clarify the duration and protective nature of humoral responses to SARS-CoV-2 infection.
Top-30
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1 publication, 3.33%
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1 publication, 3.33%
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1 publication, 3.33%
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1 publication, 3.33%
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1 publication, 3.33%
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1 publication, 3.33%
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1 publication, 3.33%
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Citations by publishers
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Springer Nature
7 publications, 23.33%
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4 publications, 13.33%
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3 publications, 10%
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2 publications, 6.67%
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1 publication, 3.33%
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Wolters Kluwer Health
1 publication, 3.33%
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PagePress
1 publication, 3.33%
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Public Library of Science (PLoS)
1 publication, 3.33%
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Wiley
1 publication, 3.33%
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Taylor & Francis
1 publication, 3.33%
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American Medical Association (AMA)
1 publication, 3.33%
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AME Publishing Company
1 publication, 3.33%
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Elsevier
1 publication, 3.33%
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 3.33%
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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MLA
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GOST
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Staines H. M. et al. IgG Seroconversion and Pathophysiology in Severe Acute Respiratory Syndrome Coronavirus 2 Infection // Emerging Infectious Diseases. 2020. Vol. 27. No. 1. pp. 85-91.
GOST all authors (up to 50)
Copy
Staines H. M., Kirwan D., Clark D. J., Adams E. R., Augustin Y., Byrne R., Cocozza M., Cubas-Atienzar A. I., Cuevas L. E., Cusinato M., Davies B. M., Davis M. E., Davis P., Duvoix A., Eckersley N. M., Forton D. M., Fraser A. J., Garrod G., Hadcocks L., Hu Q., Johnson M., Kay G. A., Klekotko K., Lewis Z., Macallan D., Mensah-Kane J., Menzies S., MONAHAN I. M., Moore C. P., Nebe-von-Caron G., Owen S., Sainter C., Sall A. A., Schouten J., Williams C., WILKINS J., Woolston K., Fitchett J. R., Krishna S., Planche T. IgG Seroconversion and Pathophysiology in Severe Acute Respiratory Syndrome Coronavirus 2 Infection // Emerging Infectious Diseases. 2020. Vol. 27. No. 1. pp. 85-91.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3201/eid2701.203074
UR - https://doi.org/10.3201/eid2701.203074
TI - IgG Seroconversion and Pathophysiology in Severe Acute Respiratory Syndrome Coronavirus 2 Infection
T2 - Emerging Infectious Diseases
AU - Staines, Henry M.
AU - Kirwan, Daniela
AU - Clark, David J
AU - Adams, Emily R.
AU - Augustin, Yolanda
AU - Byrne, Rachel
AU - Cocozza, Michael
AU - Cubas-Atienzar, Ana I.
AU - Cuevas, Luis E.
AU - Cusinato, Martina
AU - Davies, Benedict M.O.
AU - Davis, Mark E.
AU - Davis, P.
AU - Duvoix, Annelyse
AU - Eckersley, Nicholas M.
AU - Forton, Daniel M.
AU - Fraser, Alice J.
AU - Garrod, Gala
AU - Hadcocks, Linda
AU - Hu, Qinxue
AU - Johnson, Michael
AU - Kay, Grant A.
AU - Klekotko, Kesja
AU - Lewis, Zawditu
AU - Macallan, Derek
AU - Mensah-Kane, Josephine
AU - Menzies, Stefanie
AU - MONAHAN, IRENE M.
AU - Moore, Catherine Porter
AU - Nebe-von-Caron, Gerhard
AU - Owen, S.
AU - Sainter, Chris
AU - Sall, Amadou A
AU - Schouten, James
AU - Williams, Christopher
AU - WILKINS, JOHN
AU - Woolston, Kevin
AU - Fitchett, Joseph R.
AU - Krishna, Sanjeev
AU - Planche, Tim
PY - 2020
DA - 2020/12/01 00:00:00
PB - Centers for Disease Control and Prevention (CDC)
SP - 85-91
IS - 1
VL - 27
SN - 1080-6040
SN - 1080-6059
ER -
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@article{2020_Staines,
author = {Henry M. Staines and Daniela Kirwan and David J Clark and Emily R. Adams and Yolanda Augustin and Rachel Byrne and Michael Cocozza and Ana I. Cubas-Atienzar and Luis E. Cuevas and Martina Cusinato and Benedict M.O. Davies and Mark E. Davis and P. Davis and Annelyse Duvoix and Nicholas M. Eckersley and Daniel M. Forton and Alice J. Fraser and Gala Garrod and Linda Hadcocks and Qinxue Hu and Michael Johnson and Grant A. Kay and Kesja Klekotko and Zawditu Lewis and Derek Macallan and Josephine Mensah-Kane and Stefanie Menzies and IRENE M. MONAHAN and Catherine Porter Moore and Gerhard Nebe-von-Caron and S. Owen and Chris Sainter and Amadou A Sall and James Schouten and Christopher Williams and JOHN WILKINS and Kevin Woolston and Joseph R. Fitchett and Sanjeev Krishna and Tim Planche},
title = {IgG Seroconversion and Pathophysiology in Severe Acute Respiratory Syndrome Coronavirus 2 Infection},
journal = {Emerging Infectious Diseases},
year = {2020},
volume = {27},
publisher = {Centers for Disease Control and Prevention (CDC)},
month = {dec},
url = {https://doi.org/10.3201/eid2701.203074},
number = {1},
pages = {85--91},
doi = {10.3201/eid2701.203074}
}
Cite this
MLA
Copy
Staines, Henry M., et al. “IgG Seroconversion and Pathophysiology in Severe Acute Respiratory Syndrome Coronavirus 2 Infection.” Emerging Infectious Diseases, vol. 27, no. 1, Dec. 2020, pp. 85-91. https://doi.org/10.3201/eid2701.203074.
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