Open Access
Systematic Review and Meta-analysis of Postexposure Prophylaxis for Crimean-Congo Hemorrhagic Fever Virus among Healthcare Workers
Önder Ergönül
1
,
Siran Keske
2
,
Melis Gökçe Çeldir
1
,
İlayda Arjen Kara
1
,
Natalia Pshenichnaya
3
,
Abuova Gulzhan
4
,
Lucille H. Blumberg
5
2
American Hospital
4
South-Kazakhstan State Pharmaceutical Academy
5
National Institute for Communicable Diseases
Publication type: Journal Article
Publication date: 2018-07-24
scimago Q1
wos Q1
SJR: 1.879
CiteScore: 10.7
Impact factor: 6.6
ISSN: 10806040, 10806059
PubMed ID:
30124196
Microbiology (medical)
Infectious Diseases
Epidemiology
Abstract
We performed a systematic review and meta-analysis on the effectiveness of ribavirin use for the prevention of infection and death of healthcare workers exposed to patients with Crimean-Congo hemorrhagic fever virus (CCHFV) infection. Splashes with blood or bodily fluids (odds ratio [OR] 4.2), being a nurse or physician (OR 2.1), and treating patients who died from CCHFV infection (OR 3.8) were associated with healthcare workers acquiring CCHFV infection; 7% of the workers who received postexposure prophylaxis (PEP) with ribavirin and 89% of those who did not became infected. PEP with ribavirin reduced the odds of infection (OR 0.01, 95% CI 0-0.03), and ribavirin use <48 hours after symptom onset reduced the odds of death (OR 0.03, 95% CI 0-0.58). The odds of death increased 2.4-fold every day without ribavirin treatment. Ribavirin should be recommended as PEP and early treatment for workers at medium-to-high risk for CCHFV infection.
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Metrics
30
Total citations:
30
Citations from 2024:
8
(26.66%)
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MLA
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GOST
Copy
Ergönül Ö. et al. Systematic Review and Meta-analysis of Postexposure Prophylaxis for Crimean-Congo Hemorrhagic Fever Virus among Healthcare Workers // Emerging Infectious Diseases. 2018. Vol. 24. No. 9. pp. 1642-1648.
GOST all authors (up to 50)
Copy
Ergönül Ö., Keske S., Çeldir M. G., Kara İ. A., Pshenichnaya N., Gulzhan A., Blumberg L. H. Systematic Review and Meta-analysis of Postexposure Prophylaxis for Crimean-Congo Hemorrhagic Fever Virus among Healthcare Workers // Emerging Infectious Diseases. 2018. Vol. 24. No. 9. pp. 1642-1648.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3201/eid2409.171709
UR - https://doi.org/10.3201/eid2409.171709
TI - Systematic Review and Meta-analysis of Postexposure Prophylaxis for Crimean-Congo Hemorrhagic Fever Virus among Healthcare Workers
T2 - Emerging Infectious Diseases
AU - Ergönül, Önder
AU - Keske, Siran
AU - Çeldir, Melis Gökçe
AU - Kara, İlayda Arjen
AU - Pshenichnaya, Natalia
AU - Gulzhan, Abuova
AU - Blumberg, Lucille H.
PY - 2018
DA - 2018/07/24
PB - Centers for Disease Control and Prevention (CDC)
SP - 1642-1648
IS - 9
VL - 24
PMID - 30124196
SN - 1080-6040
SN - 1080-6059
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2018_Ergönül,
author = {Önder Ergönül and Siran Keske and Melis Gökçe Çeldir and İlayda Arjen Kara and Natalia Pshenichnaya and Abuova Gulzhan and Lucille H. Blumberg},
title = {Systematic Review and Meta-analysis of Postexposure Prophylaxis for Crimean-Congo Hemorrhagic Fever Virus among Healthcare Workers},
journal = {Emerging Infectious Diseases},
year = {2018},
volume = {24},
publisher = {Centers for Disease Control and Prevention (CDC)},
month = {jul},
url = {https://doi.org/10.3201/eid2409.171709},
number = {9},
pages = {1642--1648},
doi = {10.3201/eid2409.171709}
}
Cite this
MLA
Copy
Ergönül, Önder, et al. “Systematic Review and Meta-analysis of Postexposure Prophylaxis for Crimean-Congo Hemorrhagic Fever Virus among Healthcare Workers.” Emerging Infectious Diseases, vol. 24, no. 9, Jul. 2018, pp. 1642-1648. https://doi.org/10.3201/eid2409.171709.