Open Access
Open access
RTU MIREA
Fine Chemical Technologies
,  volume 16 ,  issue 1 ,  pages 88-98

Development of the technique for quality control of 1,3-bis(3,4-dicyanophenoxy)benzene by HPLC

Publication type: Journal Article
Publication date: 2021-03-18
RTU MIREA
scimago Q4
SJR: 0.214
CiteScore: 1.5
Impact factor: —
ISSN: 24106593, 26867575
General Medicine
Abstract

Objectives. Determination of target products and byproducts is necessary for the quality control of phthalonitrile monomer synthesis as well as production scaling and performing related kinetic studies. High-performance liquid chromatography (HPLC) is a simple and affordable method for quantitative chemical analysis, which also verifies the quality of raw materials. The objective of this study was to develop an HPLC technique for determining the composition of the reaction mixture in the synthesis of 1,3-bis(3,4-dicyanophenoxy)benzene (DPB).

Methods. Reversed-phase HPLC was used to quantitatively analyze the reaction mixture.

Results. A simple and rapid method for the quantitative HPLC analysis of phthalonitrile monomers and their mixtures with reagents was developed. Reaction times and the accumulation of byproducts were also studied.

Conclusions. The successful performance of the developed technique allows us to recommend it for practical applications. The results obtained for reactors of different sizes have good convergence, and DPB synthesis was successfully scaled up to intermediate scale equipment.

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Shchekoldina Z. N. et al. Development of the technique for quality control of 1,3-bis(3,4-dicyanophenoxy)benzene by HPLC // Fine Chemical Technologies. 2021. Vol. 16. No. 1. pp. 88-98.
GOST all authors (up to 50) Copy
Shchekoldina Z. N., Bogolyubov A. A., Zakharov A. Yu., Bulgakov B., Babkin A., Kepman A. Development of the technique for quality control of 1,3-bis(3,4-dicyanophenoxy)benzene by HPLC // Fine Chemical Technologies. 2021. Vol. 16. No. 1. pp. 88-98.
RIS |
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RIS Copy
TY - JOUR
DO - 10.32362/2410-6593-2021-16-1-88-98
UR - https://www.finechem-mirea.ru/jour/article/view/1689
TI - Development of the technique for quality control of 1,3-bis(3,4-dicyanophenoxy)benzene by HPLC
T2 - Fine Chemical Technologies
AU - Shchekoldina, Z N
AU - Bogolyubov, A A
AU - Zakharov, A Yu
AU - Bulgakov, Boris
AU - Babkin, Alexander
AU - Kepman, A.V.
PY - 2021
DA - 2021/03/18
PB - RTU MIREA
SP - 88-98
IS - 1
VL - 16
SN - 2410-6593
SN - 2686-7575
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2021_Shchekoldina,
author = {Z N Shchekoldina and A A Bogolyubov and A Yu Zakharov and Boris Bulgakov and Alexander Babkin and A.V. Kepman},
title = {Development of the technique for quality control of 1,3-bis(3,4-dicyanophenoxy)benzene by HPLC},
journal = {Fine Chemical Technologies},
year = {2021},
volume = {16},
publisher = {RTU MIREA},
month = {mar},
url = {https://www.finechem-mirea.ru/jour/article/view/1689},
number = {1},
pages = {88--98},
doi = {10.32362/2410-6593-2021-16-1-88-98}
}
MLA
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Shchekoldina, Z. N., et al. “Development of the technique for quality control of 1,3-bis(3,4-dicyanophenoxy)benzene by HPLC.” Fine Chemical Technologies, vol. 16, no. 1, Mar. 2021, pp. 88-98. https://www.finechem-mirea.ru/jour/article/view/1689.