Acta Naturae, volume 5, issue 2, pages 19-39

Blood Clotting Factor VIII: From Evolution to Therapy

Orlova N A

Kovnir S V

Vorobiev I I

Gabibov A. G.

Vorobiev A I

Publication type: Journal Article

Publication date: 2013-06-15

Acta Naturae Ltd

Journal: Acta Naturae

Quartile SCImago

Quartile WOS

Impact factor: 2

ISSN: 20758251, 20758243

DOI: 10.32607/20758251-2013-5-2-19-39

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Biochemistry

Molecular Biology

Molecular Medicine

Biotechnology

Abstract

Recombinant blood clotting factor VIII is one of the most complex proteins for industrial manufacturing due to the low efficiency of its gene transcription, massive intracellular loss of its proprotein during post-translational processing, and the instability of the secreted protein. Improvement in hemophilia A therapy requires a steady increase in the production of factor VIII drugs despite tightening standards of product quality and viral safety. More efficient systems for heterologous expression of factor VIII can be created on the basis of the discovered properties of its gene transcription, post-translational processing, and behavior in the bloodstream. The present review describes the deletion variants of factor VIII protein with increased secretion efficiency and the prospects for the pharmaceutical development of longer acting variants and derivatives of factor VIII.

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Citations by journals

	1 2
Therapeutic Advances in Hematology	Therapeutic Advances in Hematology, 2, 5.13% Therapeutic Advances in Hematology 2 publications, 5.13%
Biochemical and Biophysical Research Communications	Biochemical and Biophysical Research Communications, 2, 5.13% Biochemical and Biophysical Research Communications 2 publications, 5.13%
Haemophilia	Haemophilia, 2, 5.13% Haemophilia 2 publications, 5.13%
European Journal of Haematology	European Journal of Haematology, 2, 5.13% European Journal of Haematology 2 publications, 5.13%
Journal of Evolutionary Biochemistry and Physiology	Journal of Evolutionary Biochemistry and Physiology, 2, 5.13% Journal of Evolutionary Biochemistry and Physiology 2 publications, 5.13%
Expert Opinion on Biological Therapy	Expert Opinion on Biological Therapy, 2, 5.13% Expert Opinion on Biological Therapy 2 publications, 5.13%
Biological Products Prevention Diagnosis Treatment	Biological Products Prevention Diagnosis Treatment, 2, 5.13% Biological Products Prevention Diagnosis Treatment 2 publications, 5.13%
Russian Journal of Genetics	Russian Journal of Genetics, 1, 2.56% Russian Journal of Genetics 1 publication, 2.56%
Blood Coagulation and Fibrinolysis	Blood Coagulation and Fibrinolysis, 1, 2.56% Blood Coagulation and Fibrinolysis 1 publication, 2.56%
Current Medicinal Chemistry	Current Medicinal Chemistry, 1, 2.56% Current Medicinal Chemistry 1 publication, 2.56%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 1, 2.56% International Journal of Molecular Sciences 1 publication, 2.56%
Biomedicines	Biomedicines, 1, 2.56% Biomedicines 1 publication, 2.56%
Frontiers in Plant Science	Frontiers in Plant Science, 1, 2.56% Frontiers in Plant Science 1 publication, 2.56%
Frontiers in Cell and Developmental Biology	Frontiers in Cell and Developmental Biology, 1, 2.56% Frontiers in Cell and Developmental Biology 1 publication, 2.56%
Frontiers in Physiology	Frontiers in Physiology, 1, 2.56% Frontiers in Physiology 1 publication, 2.56%
BMC Biotechnology	BMC Biotechnology, 1, 2.56% BMC Biotechnology 1 publication, 2.56%
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy	Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 1, 2.56% Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy 1 publication, 2.56%
PLoS ONE	PLoS ONE, 1, 2.56% PLoS ONE 1 publication, 2.56%
Journal of Biotechnology	Journal of Biotechnology, 1, 2.56% Journal of Biotechnology 1 publication, 2.56%
Biomedical Journal	Biomedical Journal, 1, 2.56% Biomedical Journal 1 publication, 2.56%
Research and Practice in Thrombosis and Haemostasis	Research and Practice in Thrombosis and Haemostasis, 1, 2.56% Research and Practice in Thrombosis and Haemostasis 1 publication, 2.56%
Infection, Genetics and Evolution	Infection, Genetics and Evolution, 1, 2.56% Infection, Genetics and Evolution 1 publication, 2.56%
International Journal of Biological Macromolecules	International Journal of Biological Macromolecules, 1, 2.56% International Journal of Biological Macromolecules 1 publication, 2.56%
Biotechnology Journal	Biotechnology Journal, 1, 2.56% Biotechnology Journal 1 publication, 2.56%
Plant Biotechnology Journal	Plant Biotechnology Journal, 1, 2.56% Plant Biotechnology Journal 1 publication, 2.56%
Nanoscale Advances	Nanoscale Advances, 1, 2.56% Nanoscale Advances 1 publication, 2.56%
Expert Review of Hematology	Expert Review of Hematology, 1, 2.56% Expert Review of Hematology 1 publication, 2.56%
Progress in molecular and subcellular biology	Progress in molecular and subcellular biology, 1, 2.56% Progress in molecular and subcellular biology 1 publication, 2.56%
The Animal Biology	The Animal Biology, 1, 2.56% The Animal Biology 1 publication, 2.56%

	1 2

Citations by publishers

	1 2 3 4 5 6 7
Elsevier	Elsevier, 7, 17.95% Elsevier 7 publications, 17.95%
Wiley	Wiley, 7, 17.95% Wiley 7 publications, 17.95%
Pleiades Publishing	Pleiades Publishing, 3, 7.69% Pleiades Publishing 3 publications, 7.69%
Frontiers Media S.A.	Frontiers Media S.A., 3, 7.69% Frontiers Media S.A. 3 publications, 7.69%
Springer Nature	Springer Nature, 3, 7.69% Springer Nature 3 publications, 7.69%
Taylor & Francis	Taylor & Francis, 3, 7.69% Taylor & Francis 3 publications, 7.69%
SAGE	SAGE, 2, 5.13% SAGE 2 publications, 5.13%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 2, 5.13% Multidisciplinary Digital Publishing Institute (MDPI) 2 publications, 5.13%
Scientific Center for Expert Evaluation of Medicinal Products (SCEEMP)	Scientific Center for Expert Evaluation of Medicinal Products (SCEEMP), 2, 5.13% Scientific Center for Expert Evaluation of Medicinal Products (SCEEMP) 2 publications, 5.13%
Wolters Kluwer Health	Wolters Kluwer Health, 1, 2.56% Wolters Kluwer Health 1 publication, 2.56%
Bentham Science	Bentham Science, 1, 2.56% Bentham Science 1 publication, 2.56%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 1, 2.56% Public Library of Science (PLoS) 1 publication, 2.56%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 1, 2.56% Royal Society of Chemistry (RSC) 1 publication, 2.56%
National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)	National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications), 1, 2.56% National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications) 1 publication, 2.56%
	1 2 3 4 5 6 7

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GOST Copy

Orlova N. A. et al. Blood Clotting Factor VIII: From Evolution to Therapy // Acta Naturae. 2013. Vol. 5. No. 2. pp. 19-39.

GOST all authors (up to 50) Copy

Orlova N. A., Kovnir S. V., Vorobiev I. I., Gabibov A. G., Vorobiev A. I. Blood Clotting Factor VIII: From Evolution to Therapy // Acta Naturae. 2013. Vol. 5. No. 2. pp. 19-39.

RIS |

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RIS Copy

TY - JOUR

DO - 10.32607/20758251-2013-5-2-19-39

UR - https://doi.org/10.32607%2F20758251-2013-5-2-19-39

TI - Blood Clotting Factor VIII: From Evolution to Therapy

T2 - Acta Naturae

AU - Orlova, N A

AU - Kovnir, S V

AU - Vorobiev, I I

AU - Gabibov, A. G.

AU - Vorobiev, A I

PY - 2013

DA - 2013/06/15 00:00:00

PB - Acta Naturae Ltd

SP - 19-39

IS - 2

VL - 5

SN - 2075-8251

SN - 2075-8243

ER -

BibTex |

Cite this

BibTex Copy

@article{2013_Orlova,

author = {N A Orlova and S V Kovnir and I I Vorobiev and A. G. Gabibov and A I Vorobiev},

title = {Blood Clotting Factor VIII: From Evolution to Therapy},

journal = {Acta Naturae},

year = {2013},

volume = {5},

publisher = {Acta Naturae Ltd},

month = {jun},

url = {https://doi.org/10.32607%2F20758251-2013-5-2-19-39},

number = {2},

pages = {19--39},

doi = {10.32607/20758251-2013-5-2-19-39}

}

MLA

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MLA Copy

Orlova, N. A., et al. “Blood Clotting Factor VIII: From Evolution to Therapy.” Acta Naturae, vol. 5, no. 2, Jun. 2013, pp. 19-39. https://doi.org/10.32607%2F20758251-2013-5-2-19-39.

Found error?

Publisher

Acta Naturae Ltd

Journal

Acta Naturae

Quartile SCImago

Quartile WOS

Impact factor

ISSN

20758251 (Print)
20758243 (Print)

Labs

Laboratory of Mammalian Cell Bioengineering

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