Acta Naturae, volume 4, issue 2, pages 44-61
Telomere Lengthening and Other Functions of Telomerase
Publication type: Journal Article
Publication date: 2012-06-15
Biochemistry
Molecular Biology
Molecular Medicine
Biotechnology
Abstract
Telomerase is an enzyme that maintains the length of the telomere. The telomere length specifies the number of divisions a cell can undergo before it finally dies (i.e. the proliferative potential of cells). For example, telomerase is activated in embryonic cell lines and the telomere length is maintained at a constant level; therefore, these cells have an unlimited fission potential. Stem cells are characterized by a lower telomerase activity, which enables only partial compensation for the shortening of telomeres. Somatic cells are usually characterized by the absence of telomerase activity. Telomere shortening leads to the attainment of the Hayflick limit, the transition of cells to a state of senescence. The cells subsequently enter a state of crisis, accompanied by massive cell death. The surviving cells become cancer cells, which are capable both of dividing indefinitely and maintaining telomere length (usually with the aid of telomerase). Telomerase is a reverse transcriptase. It consists of two major components: telomerase RNA (TER) and reverse transcriptase (TERT). TER is a non-coding RNA, and it contains the region which serves as a template for telomere synthesis. An increasing number of articles focussing on the alternative functions of telomerase components have recently started appearing. The present review summarizes data on the structure, biogenesis, and functions of telomerase.
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14 publications, 40%
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Taylor & Francis
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1 publication, 2.86%
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1 publication, 2.86%
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Wiley
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1 publication, 2.86%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Rubtsova M. P. et al. Telomere Lengthening and Other Functions of Telomerase // Acta Naturae. 2012. Vol. 4. No. 2. pp. 44-61.
GOST all authors (up to 50)
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Rubtsova M. P., Vasilkova D. P., Malyavko A. N., Naraikina Yu. V., Zvereva M. I., Dontsova O. A. Telomere Lengthening and Other Functions of Telomerase // Acta Naturae. 2012. Vol. 4. No. 2. pp. 44-61.
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RIS
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TY - JOUR
DO - 10.32607/20758251-2012-4-2-44-61
UR - https://doi.org/10.32607%2F20758251-2012-4-2-44-61
TI - Telomere Lengthening and Other Functions of Telomerase
T2 - Acta Naturae
AU - Rubtsova, M. P.
AU - Vasilkova, D P
AU - Malyavko, A N
AU - Naraikina, Yu V
AU - Zvereva, M I
AU - Dontsova, O. A.
PY - 2012
DA - 2012/06/15 00:00:00
PB - Acta Naturae Ltd
SP - 44-61
IS - 2
VL - 4
SN - 2075-8251
SN - 2075-8243
ER -
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@article{2012_Rubtsova,
author = {M. P. Rubtsova and D P Vasilkova and A N Malyavko and Yu V Naraikina and M I Zvereva and O. A. Dontsova},
title = {Telomere Lengthening and Other Functions of Telomerase},
journal = {Acta Naturae},
year = {2012},
volume = {4},
publisher = {Acta Naturae Ltd},
month = {jun},
url = {https://doi.org/10.32607%2F20758251-2012-4-2-44-61},
number = {2},
pages = {44--61},
doi = {10.32607/20758251-2012-4-2-44-61}
}
Cite this
MLA
Copy
Rubtsova, M. P., et al. “Telomere Lengthening and Other Functions of Telomerase.” Acta Naturae, vol. 4, no. 2, Jun. 2012, pp. 44-61. https://doi.org/10.32607%2F20758251-2012-4-2-44-61.