Acta Naturae, volume 11, issue 4, pages 42-53

DARPins: Promising Scaffolds for Theranostics

Shilova O.N., Deyev S.M.

Publication type: Journal Article

Publication date: 2019-12-15

Acta Naturae Ltd

Journal: Acta Naturae

Quartile SCImago

Quartile WOS

Impact factor: 2

ISSN: 20758251, 20758243

DOI: 10.32607/20758251-2019-11-4-42-53

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Biochemistry

Molecular Biology

Molecular Medicine

Biotechnology

Abstract

Monoclonal antibodies are the classical basis for targeted therapy, but the development of alternative binding proteins has made it possible to use non-immunoglobulin proteins as targeting modules. The advantages of DARPins, scaffold proteins based on ankyrin repeats, over antibodies are as follows: small size, stability over a wide range of temperatures and pH values, low aggregation tendency, and ease of production in heterologous expression systems. The differences in the structure of the paratope of DARPin and antibodies broaden the spectrum of target molecules, while the ease of creating hybrid fusion proteins allows one to obtain bispecific and multivalent constructs. In this article, we summarize recent data on the development of therapeutic and imaging compounds based on DARPins.

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Citations by journals

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Molecules	Molecules, 3, 7.5% Molecules 3 publications, 7.5%
Acta Naturae	Acta Naturae, 3, 7.5% Acta Naturae 3 publications, 7.5%
Bulletin of Siberian Medicine	Bulletin of Siberian Medicine, 3, 7.5% Bulletin of Siberian Medicine 3 publications, 7.5%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 2, 5% International Journal of Molecular Sciences 2 publications, 5%
Biomolecules	Biomolecules, 2, 5% Biomolecules 2 publications, 5%
Russian Chemical Reviews	Russian Chemical Reviews, 2, 5% Russian Chemical Reviews 2 publications, 5%
Nanobiotechnology Reports	Nanobiotechnology Reports, 2, 5% Nanobiotechnology Reports 2 publications, 5%
Nanomedicine	Nanomedicine, 1, 2.5% Nanomedicine 1 publication, 2.5%
Sensors	Sensors, 1, 2.5% Sensors 1 publication, 2.5%
Cancers	Cancers, 1, 2.5% Cancers 1 publication, 2.5%
Frontiers in Molecular Biosciences	Frontiers in Molecular Biosciences, 1, 2.5% Frontiers in Molecular Biosciences 1 publication, 2.5%
Journal of Structural Biology	Journal of Structural Biology, 1, 2.5% Journal of Structural Biology 1 publication, 2.5%
Molecular Therapy - Oncolytics	Molecular Therapy - Oncolytics, 1, 2.5% Molecular Therapy - Oncolytics 1 publication, 2.5%
International Journal of Pharmaceutics	International Journal of Pharmaceutics, 1, 2.5% International Journal of Pharmaceutics 1 publication, 2.5%
Drug Discovery Today	Drug Discovery Today, 1, 2.5% Drug Discovery Today 1 publication, 2.5%
Small	Small, 1, 2.5% Small 1 publication, 2.5%
Medicinal Research Reviews	Medicinal Research Reviews, 1, 2.5% Medicinal Research Reviews 1 publication, 2.5%
Analysis & Sensing	Analysis & Sensing, 1, 2.5% Analysis & Sensing 1 publication, 2.5%
Biomacromolecules	Biomacromolecules, 1, 2.5% Biomacromolecules 1 publication, 2.5%
Chemical Science	Chemical Science, 1, 2.5% Chemical Science 1 publication, 2.5%
Russian Journal of Bioorganic Chemistry	Russian Journal of Bioorganic Chemistry, 1, 2.5% Russian Journal of Bioorganic Chemistry 1 publication, 2.5%
Molecular Biology	Molecular Biology, 1, 2.5% Molecular Biology 1 publication, 2.5%
European Journal of Nuclear Medicine and Molecular Imaging	European Journal of Nuclear Medicine and Molecular Imaging, 1, 2.5% European Journal of Nuclear Medicine and Molecular Imaging 1 publication, 2.5%
Biochemistry (Moscow)	Biochemistry (Moscow), 1, 2.5% Biochemistry (Moscow) 1 publication, 2.5%
Advanced Science	Advanced Science, 1, 2.5% Advanced Science 1 publication, 2.5%
Cells	Cells, 1, 2.5% Cells 1 publication, 2.5%
Advances in Protein Chemistry and Structural Biology	Advances in Protein Chemistry and Structural Biology, 1, 2.5% Advances in Protein Chemistry and Structural Biology 1 publication, 2.5%
Journal of Biomolecular Structure and Dynamics	Journal of Biomolecular Structure and Dynamics, 1, 2.5% Journal of Biomolecular Structure and Dynamics 1 publication, 2.5%
Biochemistry	Biochemistry, 1, 2.5% Biochemistry 1 publication, 2.5%
Current Protocols	Current Protocols, 1, 2.5% Current Protocols 1 publication, 2.5%
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Citations by publishers

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Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 10, 25% Multidisciplinary Digital Publishing Institute (MDPI) 10 publications, 25%
Elsevier	Elsevier, 5, 12.5% Elsevier 5 publications, 12.5%
Wiley	Wiley, 5, 12.5% Wiley 5 publications, 12.5%
Pleiades Publishing	Pleiades Publishing, 5, 12.5% Pleiades Publishing 5 publications, 12.5%
Acta Naturae Ltd	Acta Naturae Ltd, 3, 7.5% Acta Naturae Ltd 3 publications, 7.5%
Siberian State Medical University	Siberian State Medical University, 3, 7.5% Siberian State Medical University 3 publications, 7.5%
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii	Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii, 2, 5% Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii 2 publications, 5%
American Chemical Society (ACS)	American Chemical Society (ACS), 2, 5% American Chemical Society (ACS) 2 publications, 5%
Future Medicine	Future Medicine, 1, 2.5% Future Medicine 1 publication, 2.5%
Frontiers Media S.A.	Frontiers Media S.A., 1, 2.5% Frontiers Media S.A. 1 publication, 2.5%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 1, 2.5% Royal Society of Chemistry (RSC) 1 publication, 2.5%
Springer Nature	Springer Nature, 1, 2.5% Springer Nature 1 publication, 2.5%
Taylor & Francis	Taylor & Francis, 1, 2.5% Taylor & Francis 1 publication, 2.5%
	2 4 6 8 10

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Shilova O.N., Deyev S.M. DARPins: Promising Scaffolds for Theranostics // Acta Naturae. 2019. Vol. 11. No. 4. pp. 42-53.

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Shilova O.N., Deyev S.M. DARPins: Promising Scaffolds for Theranostics // Acta Naturae. 2019. Vol. 11. No. 4. pp. 42-53.

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RIS Copy

TY - JOUR

DO - 10.32607/20758251-2019-11-4-42-53

UR - https://doi.org/10.32607/20758251-2019-11-4-42-53

TI - DARPins: Promising Scaffolds for Theranostics

T2 - Acta Naturae

AU - Shilova, O N

AU - Deyev, S M

PY - 2019

DA - 2019/12/15 00:00:00

PB - Acta Naturae Ltd

SP - 42-53

IS - 4

VL - 11

SN - 2075-8251

SN - 2075-8243

ER -

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BibTex Copy

@article{2019,

author = {O N Shilova and S M Deyev},

title = {DARPins: Promising Scaffolds for Theranostics},

journal = {Acta Naturae},

year = {2019},

volume = {11},

publisher = {Acta Naturae Ltd},

month = {dec},

url = {https://doi.org/10.32607/20758251-2019-11-4-42-53},

number = {4},

pages = {42--53},

doi = {10.32607/20758251-2019-11-4-42-53}

}

Found error?

Publisher

Acta Naturae Ltd

Journal

Acta Naturae

Quartile SCImago

Quartile WOS

Impact factor

ISSN

20758251 (Print)
20758243 (Print)