Specificity of Penicillin Acylases in Deprotection of N-Benzyloxycarbonyl Derivatives of Amino Acids
Publication type: Journal Article
Publication date: 2023-05-03
scimago Q2
wos Q4
SJR: 0.633
CiteScore: 3.4
Impact factor: 2.0
ISSN: 20758251, 20758243
PubMed ID:
37153508
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Abstract
Changes in the structure of the N-acyl group in N-acylated amino acid derivatives significantly affect both the recognition and activity of penicillin acylases on this series of substrates. However, penicillin acylases from both Alcaligenes faecalis and Escherichia coli are capable of removing the N-benzyloxycarbonyl protecting group in amino acid derivatives under mild conditions without the use of toxic reagents. Efficiency in using penicillin acylases in preparative organic synthesis can be improved by utilizing modern rational enzyme design methods.
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Morozova I. A. et al. Specificity of Penicillin Acylases in Deprotection of N-Benzyloxycarbonyl Derivatives of Amino Acids // Acta Naturae. 2023. Vol. 15. No. 1. pp. 69-73.
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Morozova I. A., Guranda D. F., Panin N. V., Švedas V. K. Specificity of Penicillin Acylases in Deprotection of N-Benzyloxycarbonyl Derivatives of Amino Acids // Acta Naturae. 2023. Vol. 15. No. 1. pp. 69-73.
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RIS
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TY - JOUR
DO - 10.32607/actanaturae.13703
UR - https://doi.org/10.32607/actanaturae.13703
TI - Specificity of Penicillin Acylases in Deprotection of N-Benzyloxycarbonyl Derivatives of Amino Acids
T2 - Acta Naturae
AU - Morozova, Irina A
AU - Guranda, Dorel F.
AU - Panin, Nikolay V
AU - Švedas, Vytas K
PY - 2023
DA - 2023/05/03
PB - Acta Naturae Ltd
SP - 69-73
IS - 1
VL - 15
PMID - 37153508
SN - 2075-8251
SN - 2075-8243
ER -
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BibTex (up to 50 authors)
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@article{2023_Morozova,
author = {Irina A Morozova and Dorel F. Guranda and Nikolay V Panin and Vytas K Švedas},
title = {Specificity of Penicillin Acylases in Deprotection of N-Benzyloxycarbonyl Derivatives of Amino Acids},
journal = {Acta Naturae},
year = {2023},
volume = {15},
publisher = {Acta Naturae Ltd},
month = {may},
url = {https://doi.org/10.32607/actanaturae.13703},
number = {1},
pages = {69--73},
doi = {10.32607/actanaturae.13703}
}
Cite this
MLA
Copy
Morozova, Irina A., et al. “Specificity of Penicillin Acylases in Deprotection of N-Benzyloxycarbonyl Derivatives of Amino Acids.” Acta Naturae, vol. 15, no. 1, May. 2023, pp. 69-73. https://doi.org/10.32607/actanaturae.13703.