Open Access
Recent Advances and Promises in Nitrile Hydratase: From Mechanism to Industrial Applications
Publication type: Journal Article
Publication date: 2020-04-24
scimago Q1
wos Q1
SJR: 0.974
CiteScore: 8.8
Impact factor: 4.8
ISSN: 22964185
PubMed ID:
32391348
Biotechnology
Bioengineering
Histology
Biomedical Engineering
Abstract
Nitrile hydratase (NHase, EC 4.2.1.84) is one type of metalloenzyme participating in the biotransformation of nitriles into amides. Given its catalytic specificity in amide production and eco-friendliness, NHase has overwhelmed its chemical counterpart during the past few decades. However, unclear catalytic mechanism, low thermostablity, and narrow substrate specificity limit the further application of NHase. During the past few years, numerous studies on the theoretical and industrial aspects of NHase have advanced the development of this green catalyst. This review critically focuses on NHase research from recent years, including the natural distribution, gene types, posttranslational modifications, expression, proposed catalytic mechanism, biochemical properties and potential applications of NHase. The developments of NHase described here are not only useful for further application of NHase, but also beneficial for the development of the fields of biocatalysis and biotransformation.
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Metrics
63
Total citations:
63
Citations from 2024:
33
(52.38%)
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GOST
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Cheng Z., Xia Y., Zhou Z. Recent Advances and Promises in Nitrile Hydratase: From Mechanism to Industrial Applications // Frontiers in Bioengineering and Biotechnology. 2020. Vol. 8.
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Cheng Z., Xia Y., Zhou Z. Recent Advances and Promises in Nitrile Hydratase: From Mechanism to Industrial Applications // Frontiers in Bioengineering and Biotechnology. 2020. Vol. 8.
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RIS
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TY - JOUR
DO - 10.3389/fbioe.2020.00352
UR - https://doi.org/10.3389/fbioe.2020.00352
TI - Recent Advances and Promises in Nitrile Hydratase: From Mechanism to Industrial Applications
T2 - Frontiers in Bioengineering and Biotechnology
AU - Cheng, Zhongyi
AU - Xia, Yuanyuan
AU - Zhou, Zhemin
PY - 2020
DA - 2020/04/24
PB - Frontiers Media S.A.
VL - 8
PMID - 32391348
SN - 2296-4185
ER -
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@article{2020_Cheng,
author = {Zhongyi Cheng and Yuanyuan Xia and Zhemin Zhou},
title = {Recent Advances and Promises in Nitrile Hydratase: From Mechanism to Industrial Applications},
journal = {Frontiers in Bioengineering and Biotechnology},
year = {2020},
volume = {8},
publisher = {Frontiers Media S.A.},
month = {apr},
url = {https://doi.org/10.3389/fbioe.2020.00352},
doi = {10.3389/fbioe.2020.00352}
}