Ferroptosis in neurodegenerative diseases: mechanisms and therapeutic potential of stem cell derivatives

Ting Zhang 1
, 
Yusu Zhang 1
, 
Jinpeng Xie 1
, 
Dandan Lu 2
, 
Lihong Wang 1
, 
Shuaifei Zhao 1
, 
Jing Zhou 2, 3
, 
Cheng Yang 1
, 
Kou Ting 1
, 
Wang Jue 2
, 
Ying Chen 1
, 
Lei Xu 1
, 
Xiangyu Hu 2
, 
Yuxiu Ying 1
, 
Jun Wang 2
, 
Xiaoshuang Xin 1
, 
Xu Xu 2
, 
Siyun Lei 4
, 
Chenyu Qiu 4
, 
Jinhua Wu 1
, 
Qiqi Lyu 5
, 
Tong Cao 2, 4
1
 
2
 
3
 
4
 
Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, Zhejiang, China | 
5
 
Publication type: Journal Article
Publication date: 2025-03-21
Frontiers Media S.A.
scimago Q1
wos Q1
SJR: 1.608
CiteScore: 11.4
Impact factor: 4.3
ISSN: 2296634X
Abstract

Ferroptosis, a non-apoptotic, iron-dependent form of regulated cell death, is closely related to the pathogenesis of neurodegenerative diseases. Stem cells and their derivatives exhibit remarkable potential in modulating ferroptosis, offering promising therapeutic intervention for neurodegenerative diseases. In this review, we systematically explore neurological aging and its association with cognitive impairment and neurodegenerative diseases, with focus on the molecular mechanisms of ferroptosis in neurodegenerative diseases and the potential therapeutic strategies of stem cell derivatives for neurological diseases.

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GOST Copy
Zhang T. et al. Ferroptosis in neurodegenerative diseases: mechanisms and therapeutic potential of stem cell derivatives // Frontiers in Cell and Developmental Biology. 2025. Vol. 13.
GOST all authors (up to 50) Copy
Zhang T., Zhang Y., Xie J., Lu D., Wang L., Zhao S., Zhou J., Cheng Yang, Ting K., Wang Jue, Chen Y., Xu L., Hu X., Ying Y., Wang J., Xin X., Xu X., Lei S., Qiu C., Wu J., Lyu Q., Cao T. Ferroptosis in neurodegenerative diseases: mechanisms and therapeutic potential of stem cell derivatives // Frontiers in Cell and Developmental Biology. 2025. Vol. 13.
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TY - JOUR
DO - 10.3389/fcell.2025.1577382
UR - https://www.frontiersin.org/articles/10.3389/fcell.2025.1577382/full
TI - Ferroptosis in neurodegenerative diseases: mechanisms and therapeutic potential of stem cell derivatives
T2 - Frontiers in Cell and Developmental Biology
AU - Zhang, Ting
AU - Zhang, Yusu
AU - Xie, Jinpeng
AU - Lu, Dandan
AU - Wang, Lihong
AU - Zhao, Shuaifei
AU - Zhou, Jing
AU - Cheng Yang
AU - Ting, Kou
AU - Wang Jue
AU - Chen, Ying
AU - Xu, Lei
AU - Hu, Xiangyu
AU - Ying, Yuxiu
AU - Wang, Jun
AU - Xin, Xiaoshuang
AU - Xu, Xu
AU - Lei, Siyun
AU - Qiu, Chenyu
AU - Wu, Jinhua
AU - Lyu, Qiqi
AU - Cao, Tong
PY - 2025
DA - 2025/03/21
PB - Frontiers Media S.A.
VL - 13
SN - 2296-634X
ER -
BibTex
Cite this
BibTex (up to 50 authors) Copy
@article{2025_Zhang,
author = {Ting Zhang and Yusu Zhang and Jinpeng Xie and Dandan Lu and Lihong Wang and Shuaifei Zhao and Jing Zhou and Cheng Yang and Kou Ting and Wang Jue and Ying Chen and Lei Xu and Xiangyu Hu and Yuxiu Ying and Jun Wang and Xiaoshuang Xin and Xu Xu and Siyun Lei and Chenyu Qiu and Jinhua Wu and Qiqi Lyu and Tong Cao},
title = {Ferroptosis in neurodegenerative diseases: mechanisms and therapeutic potential of stem cell derivatives},
journal = {Frontiers in Cell and Developmental Biology},
year = {2025},
volume = {13},
publisher = {Frontiers Media S.A.},
month = {mar},
url = {https://www.frontiersin.org/articles/10.3389/fcell.2025.1577382/full},
doi = {10.3389/fcell.2025.1577382}
}