Open Access

Frontiers in Immunology, volume 13

The association between sedentary behavior, exercise, and sleep disturbance: A mediation analysis of inflammatory biomarkers

Yanwei You ^{1, 2}

Yuquan Chen ³

Wen Fang ^{1, 2}

Xingtian Li ^{1, 2}

Rui Wang ^{1, 2}

Jianxiu Liu ^{1, 4}

Xindong Ma ^{1, 5}

Hide authors affiliations Show authors affiliations: 5 affiliations

Division of Sports Science and Physical Education, Tsinghua University, China |

School of Social Sciences, Tsinghua University, China |

Institute of Medical Information/Medical Library, Chinese Academy of Medical Sciences & Peking Union Medical College, China |

⁴

Vanke School of Public Health, Tsinghua University, China |

⁵

IDG/McGovern Institute for Brain Research, Tsinghua University, China |

Publication type: Journal Article

Publication date: 2023-01-13

Frontiers Media S.A.

Journal: Frontiers in Immunology

Quartile SCImago

Quartile WOS

Impact factor: 7.3

ISSN: 16643224

DOI: 10.3389/fimmu.2022.1080782

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Immunology

Immunology and Allergy

Abstract

Background

Two related lifestyle behaviors associated with sleep disturbance are sedentary behavior and physical exercise participation. We aimed to use a population-based study to disentangle the relationships between sedentary behavior, exercise, and sleep disturbance based on blood-cell-based inflammatory biomarkers.

Methods

A total of 22,599 participants from the National Health and Nutrition Examination Survey (NHANES) were included in the analyses. Sleep disturbance was assessed according to the NHANES questionnaire. Exercise participation ansd sedentary behavior were evaluated by the global physical activity questionnaire. The inflammatory biomarkers in the examination were white blood cell (WBC) count, neutrophil count (NEU), neutrophil-to-lymphocyte ratio (NLR), and systemic immune inflammation index (SII). A complex multistage sampling design and weighted multivariable logistic regression were applied for further analysis. Mediation models were constructed to figure out the mediating role of inflammatory biomarkers.

Results

The weighted prevalence of sleep disturbance was 24.17%. Sedentary behavior and exercise were associated with sleep disturbance after full adjustment [for sedentary behavior, OR (95% CI): 1.261 (1.154, 1.377); for exercise, OR (95% CI): 0.849 (0.757, 0.953)]. In severe sedentary behavior groups, the mitigation effect of exercise on sleep disturbance was observed [OR (95% CI): 0.687 (0.551, 0.857)]. For the mechanism, strong associations were detected between inflammatory biomarkers and sleep disturbance. Mediation analysis showed that WBC, NEU, NLR, and SII mediated the statistical association between sedentary behavior and sleep disturbance with proportions (%) of 2.09, 2.27, 1.76, and 0.82, respectively.

Conclusions

Our data suggested that sedentary behavior was a risk factor for sleep disturbance. Blood-cell-based inflammatory biomarkers were an easily accessible and cost-effective strategy for identifying sleep disturbance and also significantly mediated the association between sedentary behavior and sleep disturbance. Exercise was proved to be effective in severe sedentary behavior groups to improve sleep disturbance symptoms, while the internal mechanism needed further exploration.

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Citations by publishers

	5 10 15 20 25
Frontiers Media S.A.	Frontiers Media S.A., 24, 35.29% Frontiers Media S.A. 24 publications, 35.29%
Springer Nature	Springer Nature, 17, 25% Springer Nature 17 publications, 25%
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Taylor & Francis	Taylor & Francis, 2, 2.94% Taylor & Francis 2 publications, 2.94%
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Dove Medical Press	Dove Medical Press, 1, 1.47% Dove Medical Press 1 publication, 1.47%
American Physiological Society	American Physiological Society, 1, 1.47% American Physiological Society 1 publication, 1.47%
Canadian Science Publishing	Canadian Science Publishing, 1, 1.47% Canadian Science Publishing 1 publication, 1.47%
Wiley	Wiley, 1, 1.47% Wiley 1 publication, 1.47%
South Florida Publishing LLC	South Florida Publishing LLC, 1, 1.47% South Florida Publishing LLC 1 publication, 1.47%
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You Y. et al. The association between sedentary behavior, exercise, and sleep disturbance: A mediation analysis of inflammatory biomarkers // Frontiers in Immunology. 2023. Vol. 13.

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You Y., Chen Y., Fang W., Li X., Wang R., Liu J., Ma X. The association between sedentary behavior, exercise, and sleep disturbance: A mediation analysis of inflammatory biomarkers // Frontiers in Immunology. 2023. Vol. 13.

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TY - JOUR

DO - 10.3389/fimmu.2022.1080782

UR - https://doi.org/10.3389/fimmu.2022.1080782

TI - The association between sedentary behavior, exercise, and sleep disturbance: A mediation analysis of inflammatory biomarkers

T2 - Frontiers in Immunology

AU - You, Yanwei

AU - Chen, Yuquan

AU - Fang, Wen

AU - Li, Xingtian

AU - Wang, Rui

AU - Liu, Jianxiu

AU - Ma, Xindong

PY - 2023

DA - 2023/01/13 00:00:00

PB - Frontiers Media S.A.

VL - 13

SN - 1664-3224

ER -

BibTex

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BibTex Copy

@article{2023_You,

author = {Yanwei You and Yuquan Chen and Wen Fang and Xingtian Li and Rui Wang and Jianxiu Liu and Xindong Ma},

title = {The association between sedentary behavior, exercise, and sleep disturbance: A mediation analysis of inflammatory biomarkers},

journal = {Frontiers in Immunology},

year = {2023},

volume = {13},

publisher = {Frontiers Media S.A.},

month = {jan},

url = {https://doi.org/10.3389/fimmu.2022.1080782},

doi = {10.3389/fimmu.2022.1080782}

}

Found error?

Publisher

Frontiers Media S.A.

Journal

Frontiers in Immunology

Quartile SCImago

Quartile WOS

Impact factor

7.3

ISSN

16643224 (Electronic)