Open Access
Open access
Frontiers Media S.A.
Frontiers in Psychiatry
,  volume 14

Exploring brain glutathione and peripheral blood markers in posttraumatic stress disorder: a combined [1H]MRS and peripheral blood study

Sarah E. Watling 1, 2
, 
Shawn G. Rhind 3, 4
, 
Jerry Warsh 1, 2, 5, 6, 7
, 
Duncan Green 1, 2
, 
Tina McCluskey 2, 5
, 
Junchao Tong 2, 5, 6
, 
Peter Truong 2
, 
Sofia Chavez 2
, 
J Don Richardson 8, 9, 10, 11
, 
Stephen J. Kish 1, 2, 5, 6, 7
, 
Isabelle Boileau 1, 2, 5, 7
1
 
2
 
3
 
4
 
Defence Research and Development Canada, Toronto Research Centre, Canada | 
5
 
6
 
7
 
8
 
The MacDonald Franklin Operational Stress Injury (OSI) Research Centre, Lawson Health Research Institute, Canada | 
9
 
10
 
11
 
St. Joseph's London Operational Stress Injury (OSI), Parkwood Institute, St. Joseph's Health Care, Canada | 
Publication type: Journal Article
Publication date: 2023-06-02
Frontiers Media S.A.
scimago Q1
wos Q2
SJR: 1.192
CiteScore: 6.2
Impact factor: 3.2
ISSN: 16640640
Psychiatry and Mental health
Abstract
Introduction

Oxidative stress has been implicated in psychiatric disorders, including posttraumatic stress disorder (PTSD). Currently, the status of glutathione (GSH), the brain's most abundant antioxidant, in PTSD remains uncertain. Therefore, the current study investigated brain concentrations of GSH and peripheral concentrations of blood markers in individuals with PTSD vs. Healthy Controls (HC).

Methods

GSH spectra was acquired in the anterior cingulate cortex (ACC) and dorsolateral prefrontal cortex (DLPFC) using MEGA-PRESS, a J-difference-editing acquisition method. Peripheral blood samples were analyzed for concentrations of metalloproteinase (MMP)-9, tissue inhibitors of MMP (TIMP)-1,2, and myeloperoxidase (MPO).

Results

There was no difference in GSH between PTSD and HC in the ACC (n = 30 PTSD, n = 20 HC) or DLPFC (n = 14 PTSD, n = 18 HC). There were no group differences between peripheral blood markers (P > 0.3) except for (non-significantly) lower TIMP-2 in PTSD. Additionally, TIMP-2 and GSH in the ACC were positively related in those with PTSD. Finally, MPO and MMP-9 were negatively associated with duration of PTSD.

Conclusions

We do not report altered GSH concentrations in the ACC or DLPFC in PTSD, however, systemic MMPs and MPO might be implicated in central processes and progression of PTSD. Future research should investigate these relationships in larger sample sizes.

Found 
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GOST Copy
Watling S. E. et al. Exploring brain glutathione and peripheral blood markers in posttraumatic stress disorder: a combined [1H]MRS and peripheral blood study // Frontiers in Psychiatry. 2023. Vol. 14.
GOST all authors (up to 50) Copy
Watling S. E., Rhind S. G., Warsh J., Green D., McCluskey T., Tong J., Truong P., Chavez S., Richardson J. D., Kish S. J., Boileau I. Exploring brain glutathione and peripheral blood markers in posttraumatic stress disorder: a combined [1H]MRS and peripheral blood study // Frontiers in Psychiatry. 2023. Vol. 14.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.3389/fpsyt.2023.1195012
UR - https://doi.org/10.3389/fpsyt.2023.1195012
TI - Exploring brain glutathione and peripheral blood markers in posttraumatic stress disorder: a combined [1H]MRS and peripheral blood study
T2 - Frontiers in Psychiatry
AU - Watling, Sarah E.
AU - Rhind, Shawn G.
AU - Warsh, Jerry
AU - Green, Duncan
AU - McCluskey, Tina
AU - Tong, Junchao
AU - Truong, Peter
AU - Chavez, Sofia
AU - Richardson, J Don
AU - Kish, Stephen J.
AU - Boileau, Isabelle
PY - 2023
DA - 2023/06/02
PB - Frontiers Media S.A.
VL - 14
PMID - 37333909
SN - 1664-0640
ER -
BibTex
Cite this
BibTex (up to 50 authors) Copy
@article{2023_Watling,
author = {Sarah E. Watling and Shawn G. Rhind and Jerry Warsh and Duncan Green and Tina McCluskey and Junchao Tong and Peter Truong and Sofia Chavez and J Don Richardson and Stephen J. Kish and Isabelle Boileau},
title = {Exploring brain glutathione and peripheral blood markers in posttraumatic stress disorder: a combined [1H]MRS and peripheral blood study},
journal = {Frontiers in Psychiatry},
year = {2023},
volume = {14},
publisher = {Frontiers Media S.A.},
month = {jun},
url = {https://doi.org/10.3389/fpsyt.2023.1195012},
doi = {10.3389/fpsyt.2023.1195012}
}