Open Access
Frontiers in Immunology, volume 11
Convalescent Plasma: The Relay Baton in the Race for Coronavirus Disease 2019 Treatment
Jing Ouyang
1, 2, 3
,
Stéphane Isnard
2, 3
,
John Lin
2, 3
,
Brandon Fombuena
2, 3, 4
,
Xiaorong Peng
2, 3, 5
,
Jean-Pierre Routy
2, 3, 6
,
Yaokai Chen
1
1
Chongqing Public Health Medical Center, China
|
Publication type: Journal Article
Publication date: 2020-09-23
Journal:
Frontiers in Immunology
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 7.3
ISSN: 16643224
Immunology
Immunology and Allergy
Abstract
Coronavirus disease 2019 (COVID-19) is a pandemic caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Most infected people have mild or moderate symptoms and recover without the need for extensive treatment. However, for serious ill patients, no specific treatments are currently available. Convalescent plasma therapy (CPT), a passive immunotherapy, involves infusing plasma from recovered people into actively infected people, and is thought to be a specific intervention to improve outcome in patients with severe COVID-19. The presumed mechanism involves neutralizing antibodies and antibody dependent cytotoxicity/phagocytosis. Previous CPT trials showed an effect in SARS and pilot studies suggest CPT is an effective and safe strategy for seriously ill COVID-19 patients. CPT is currently being tested in large randomized clinical trials. Herein, we critically review the mechanism, applications and the challenges for CPT in the treatment of severe COVID-19, paving the way toward vaccine and immunotherapy development.
Top-30
Citations by journals
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1
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Infectious Disorders - Drug Targets
1 publication, 7.69%
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JMIR Public Health and Surveillance
1 publication, 7.69%
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Life
1 publication, 7.69%
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Pathogens
1 publication, 7.69%
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Journal of Nanobiotechnology
1 publication, 7.69%
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Nature Reviews Immunology
1 publication, 7.69%
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Indian Journal of Hematology and Blood Transfusion
1 publication, 7.69%
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Infectious Diseases and Therapy
1 publication, 7.69%
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Journal of Infection and Public Health
1 publication, 7.69%
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Frontiers in Pharmacology
1 publication, 7.69%
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Russian Chemical Reviews
1 publication, 7.69%
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1
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Citations by publishers
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1
2
3
4
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Springer Nature
4 publications, 30.77%
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Multidisciplinary Digital Publishing Institute (MDPI)
2 publications, 15.38%
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Bentham Science
1 publication, 7.69%
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JMIR Publications
1 publication, 7.69%
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Elsevier
1 publication, 7.69%
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Cold Spring Harbor Laboratory
1 publication, 7.69%
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Frontiers Media S.A.
1 publication, 7.69%
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 7.69%
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1
2
3
4
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Ouyang J. et al. Convalescent Plasma: The Relay Baton in the Race for Coronavirus Disease 2019 Treatment // Frontiers in Immunology. 2020. Vol. 11.
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Ouyang J., Isnard S., Lin J., Fombuena B., Peng X., Routy J., Chen Y. Convalescent Plasma: The Relay Baton in the Race for Coronavirus Disease 2019 Treatment // Frontiers in Immunology. 2020. Vol. 11.
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TY - JOUR
DO - 10.3389/fimmu.2020.570063
UR - https://doi.org/10.3389/fimmu.2020.570063
TI - Convalescent Plasma: The Relay Baton in the Race for Coronavirus Disease 2019 Treatment
T2 - Frontiers in Immunology
AU - Ouyang, Jing
AU - Isnard, Stéphane
AU - Lin, John
AU - Fombuena, Brandon
AU - Peng, Xiaorong
AU - Routy, Jean-Pierre
AU - Chen, Yaokai
PY - 2020
DA - 2020/09/23 00:00:00
PB - Frontiers Media S.A.
VL - 11
SN - 1664-3224
ER -
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@article{2020_Ouyang,
author = {Jing Ouyang and Stéphane Isnard and John Lin and Brandon Fombuena and Xiaorong Peng and Jean-Pierre Routy and Yaokai Chen},
title = {Convalescent Plasma: The Relay Baton in the Race for Coronavirus Disease 2019 Treatment},
journal = {Frontiers in Immunology},
year = {2020},
volume = {11},
publisher = {Frontiers Media S.A.},
month = {sep},
url = {https://doi.org/10.3389/fimmu.2020.570063},
doi = {10.3389/fimmu.2020.570063}
}