Open Access
Advanced prodrug strategies in nucleoside analogues targeting the treatment of gastrointestinal malignancies
Тип публикации: Journal Article
Дата публикации: 2023-04-18
scimago Q1
wos Q1
БС1
SJR: 1.608
CiteScore: 11.4
Impact factor: 4.3
ISSN: 2296634X
PubMed ID:
37143892
Cell Biology
Developmental Biology
Краткое описание
Gastrointestinal malignancies are common digestive system tumor worldwide. Nucleoside analogues have been widely used as anticancer drugs for the treatment of a variety of conditions, including gastrointestinal malignancies. However, low permeability, enzymatic deamination, inefficiently phosphorylation, the emergence of chemoresistance and some other issues have limited its efficacy. The prodrug strategies have been widely applied in drug design to improve pharmacokinetic properties and address safety and drug-resistance issues. This review will provide an overview of the recent developments of prodrug strategies in nucleoside analogues for the treatment of gastrointestinal malignancies.
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ГОСТ
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Xu X. et al. Advanced prodrug strategies in nucleoside analogues targeting the treatment of gastrointestinal malignancies // Frontiers in Cell and Developmental Biology. 2023. Vol. 11.
ГОСТ со всеми авторами (до 50)
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Xu X., Li Z., Yao X., Sun N., Chang J. Advanced prodrug strategies in nucleoside analogues targeting the treatment of gastrointestinal malignancies // Frontiers in Cell and Developmental Biology. 2023. Vol. 11.
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TY - JOUR
DO - 10.3389/fcell.2023.1173432
UR - https://doi.org/10.3389/fcell.2023.1173432
TI - Advanced prodrug strategies in nucleoside analogues targeting the treatment of gastrointestinal malignancies
T2 - Frontiers in Cell and Developmental Biology
AU - Xu, Xingxing
AU - Li, Zixuan
AU - Yao, Xueying
AU - Sun, Nannan
AU - Chang, Junbiao
PY - 2023
DA - 2023/04/18
PB - Frontiers Media S.A.
VL - 11
PMID - 37143892
SN - 2296-634X
ER -
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BibTex (до 50 авторов)
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@article{2023_Xu,
author = {Xingxing Xu and Zixuan Li and Xueying Yao and Nannan Sun and Junbiao Chang},
title = {Advanced prodrug strategies in nucleoside analogues targeting the treatment of gastrointestinal malignancies},
journal = {Frontiers in Cell and Developmental Biology},
year = {2023},
volume = {11},
publisher = {Frontiers Media S.A.},
month = {apr},
url = {https://doi.org/10.3389/fcell.2023.1173432},
doi = {10.3389/fcell.2023.1173432}
}