Open Access
Frontiers in Chemistry, volume 7
Stabilization of Long-Looped i-Motif DNA by Polypyridyl Ruthenium Complexes
Benjamin J. Pages
1
,
Sarah P. Gurung
2, 3
,
Kane Mcquaid
2, 3
,
James P. Hall
1, 3
,
Christine J. Cardin
2
,
John A Brazier
1
3
diamond light source, United Kingdom
|
Publication type: Journal Article
Publication date: 2019-11-05
Journal:
Frontiers in Chemistry
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 5.5
ISSN: 22962646, 22962646
General Chemistry
Abstract
A spectroscopic study of the interactions of Λ- and Δ-[Ru(phen)2(dppz)]2+ with i-motif DNA containing thymine loops of various lengths. In the presence of i-motifs, the luminescence of the Λ enantiomer was enhanced much more than the Δ. Despite this, the effect of each enantiomer on i-motif thermal stability was comparable. The sequences most affected by [Ru(phen)2(dppz)]2+ were those with long thymine loops; this suggests that long-looped i-motifs are attractive targets for potential transition metal complex drugs and should be explored further in drug design.
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Pages B. J. et al. Stabilization of Long-Looped i-Motif DNA by Polypyridyl Ruthenium Complexes // Frontiers in Chemistry. 2019. Vol. 7.
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Pages B. J., Gurung S. P., Mcquaid K., Hall J. P., Cardin C. J., Brazier J. A. Stabilization of Long-Looped i-Motif DNA by Polypyridyl Ruthenium Complexes // Frontiers in Chemistry. 2019. Vol. 7.
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TY - JOUR
DO - 10.3389/fchem.2019.00744
UR - https://doi.org/10.3389/fchem.2019.00744
TI - Stabilization of Long-Looped i-Motif DNA by Polypyridyl Ruthenium Complexes
T2 - Frontiers in Chemistry
AU - Pages, Benjamin J.
AU - Gurung, Sarah P.
AU - Mcquaid, Kane
AU - Hall, James P.
AU - Cardin, Christine J.
AU - Brazier, John A
PY - 2019
DA - 2019/11/05
PB - Frontiers Media S.A.
VL - 7
SN - 2296-2646
SN - 2296-2646
ER -
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@article{2019_Pages,
author = {Benjamin J. Pages and Sarah P. Gurung and Kane Mcquaid and James P. Hall and Christine J. Cardin and John A Brazier},
title = {Stabilization of Long-Looped i-Motif DNA by Polypyridyl Ruthenium Complexes},
journal = {Frontiers in Chemistry},
year = {2019},
volume = {7},
publisher = {Frontiers Media S.A.},
month = {nov},
url = {https://doi.org/10.3389/fchem.2019.00744},
doi = {10.3389/fchem.2019.00744}
}