Open Access
,
volume 10
Synthesis and Characterization of Phenylboronic Acid-Modified Insulin With Glucose-Dependent Solubility
Nai Pin Lin
1, 2
,
Nan Zheng
2
,
Landa Purushottam
1
,
Yi Wolf Zhang
1, 2
,
Danny Hung-Chieh Chou
1, 2
1
Department of Pediatrics, United States
|
2
Department of Biochemistry, United States
|
Publication type: Journal Article
Publication date: 2022-03-16
scimago Q1
wos Q2
SJR: 0.830
CiteScore: 8.4
Impact factor: 4.2
ISSN: 22962646
PubMed ID:
35372263
General Chemistry
Abstract
Glucose-responsive insulin represents a promising approach to regulate blood glucose levels. We previously showed that attaching two fluorophenylboronic acid (FPBA) residues to the C-terminal B chain of insulin glargine led to glucose-dependent solubility. Herein, we demonstrated that relocating FPBA from B chain to A chain increased the baseline solubility without affecting its potency. Furthermore, increasing the number of FPBA groups led to increased glucose-dependent solubility.
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7
Total citations:
7
Citations from 2024:
5
(71.43%)
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GOST
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Lin N. P. et al. Synthesis and Characterization of Phenylboronic Acid-Modified Insulin With Glucose-Dependent Solubility // Frontiers in Chemistry. 2022. Vol. 10.
GOST all authors (up to 50)
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Lin N. P., Zheng N., Purushottam L., Zhang Y. W., Chou D. H. Synthesis and Characterization of Phenylboronic Acid-Modified Insulin With Glucose-Dependent Solubility // Frontiers in Chemistry. 2022. Vol. 10.
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RIS
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TY - JOUR
DO - 10.3389/fchem.2022.859133
UR - https://doi.org/10.3389/fchem.2022.859133
TI - Synthesis and Characterization of Phenylboronic Acid-Modified Insulin With Glucose-Dependent Solubility
T2 - Frontiers in Chemistry
AU - Lin, Nai Pin
AU - Zheng, Nan
AU - Purushottam, Landa
AU - Zhang, Yi Wolf
AU - Chou, Danny Hung-Chieh
PY - 2022
DA - 2022/03/16
PB - Frontiers Media S.A.
VL - 10
PMID - 35372263
SN - 2296-2646
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2022_Lin,
author = {Nai Pin Lin and Nan Zheng and Landa Purushottam and Yi Wolf Zhang and Danny Hung-Chieh Chou},
title = {Synthesis and Characterization of Phenylboronic Acid-Modified Insulin With Glucose-Dependent Solubility},
journal = {Frontiers in Chemistry},
year = {2022},
volume = {10},
publisher = {Frontiers Media S.A.},
month = {mar},
url = {https://doi.org/10.3389/fchem.2022.859133},
doi = {10.3389/fchem.2022.859133}
}