Open Access
Frontiers in Endocrinology, volume 13
The potential mechanisms and application prospects of non-coding RNAs in intervertebral disc degeneration
Jiang Chao
1
,
Chen Zhe
1
,
Wang Xiaohui
1, 2
,
Zhang Yongyuan
1
,
Guo Xinyu
1
,
Xu Zhengwei
1
,
Yang Hao
3
,
Hao Dingjun
1
2
Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Germany
|
Publication type: Journal Article
Publication date: 2022-12-08
Journal:
Frontiers in Endocrinology
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.2
ISSN: 16642392
Endocrinology, Diabetes and Metabolism
Abstract
Low back pain (LBP) is one of the most common musculoskeletal symptoms and severely affects patient quality of life. The majority of people may suffer from LBP during their life-span, which leading to huge economic burdens to family and society. According to the series of the previous studies, intervertebral disc degeneration (IDD) is considered as the major contributor resulting in LBP. Furthermore, non-coding RNAs (ncRNAs), mainly including microRNAs (miRNAs), long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs), can regulate diverse cellular processes, which have been found to play pivotal roles in the development of IDD. However, the potential mechanisms of action for ncRNAs in the processes of IDD are still completely unrevealed. Therefore, it is challenging to consider ncRNAs to be used as the potential therapeutic targets for IDD. In this paper, we reviewed the current research progress and findings on ncRNAs in IDD: i). ncRNAs mainly participate in the process of IDD through regulating apoptosis of nucleus pulposus (NP) cells, metabolism of extracellular matrix (ECM) and inflammatory response; ii). the roles of miRNAs/lncRNAs/circRNAs are cross-talk in IDD development, which is similar to the network and can modulate each other; iii). ncRNAs have been attempted to combat the degenerative processes and may be promising as an efficient bio-therapeutic strategy in the future. Hence, this review systematically summarizes the principal pathomechanisms of IDD and shed light on the therapeutic potentials of ncRNAs in IDD.
Citations by journals
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1
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Epigenomics
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1 publication, 14.29%
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Journal of Cellular and Molecular Medicine
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1 publication, 14.29%
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1 publication, 14.29%
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1 publication, 14.29%
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1 publication, 14.29%
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1 publication, 14.29%
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1
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Citations by publishers
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1
2
3
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Wiley
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Wiley
3 publications, 42.86%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
2 publications, 28.57%
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Future Medicine
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Future Medicine
1 publication, 14.29%
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Elsevier
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Elsevier
1 publication, 14.29%
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1
2
3
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Jiang C. et al. The potential mechanisms and application prospects of non-coding RNAs in intervertebral disc degeneration // Frontiers in Endocrinology. 2022. Vol. 13.
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Jiang C., Chen Z., Wang X., Zhang Y., Guo X., Xu Z., Yang H., Hao D. The potential mechanisms and application prospects of non-coding RNAs in intervertebral disc degeneration // Frontiers in Endocrinology. 2022. Vol. 13.
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TY - JOUR
DO - 10.3389/fendo.2022.1081185
UR - https://doi.org/10.3389%2Ffendo.2022.1081185
TI - The potential mechanisms and application prospects of non-coding RNAs in intervertebral disc degeneration
T2 - Frontiers in Endocrinology
AU - Jiang, Chao
AU - Chen, Zhe
AU - Wang, Xiaohui
AU - Zhang, Yongyuan
AU - Guo, Xinyu
AU - Xu, Zhengwei
AU - Yang, Hao
AU - Hao, Dingjun
PY - 2022
DA - 2022/12/08 00:00:00
PB - Frontiers Media S.A.
VL - 13
SN - 1664-2392
ER -
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@article{2022_Jiang,
author = {Chao Jiang and Zhe Chen and Xiaohui Wang and Yongyuan Zhang and Xinyu Guo and Zhengwei Xu and Hao Yang and Dingjun Hao},
title = {The potential mechanisms and application prospects of non-coding RNAs in intervertebral disc degeneration},
journal = {Frontiers in Endocrinology},
year = {2022},
volume = {13},
publisher = {Frontiers Media S.A.},
month = {dec},
url = {https://doi.org/10.3389%2Ffendo.2022.1081185},
doi = {10.3389/fendo.2022.1081185}
}