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Frontiers in Endocrinology, volume 13

The potential mechanisms and application prospects of non-coding RNAs in intervertebral disc degeneration

Chao Jiang 1
Zhe Chen 1
Xiaohui Wang 1, 2
Yongyuan Zhang 1
Xinyu Guo 1
Zhengwei Xu 1
Hao Yang 3
Dingjun Hao 1
Publication typeJournal Article
Publication date2022-12-08
Q1
Q2
SJR1.240
CiteScore5.7
Impact factor3.9
ISSN16642392
Endocrinology, Diabetes and Metabolism
Abstract

Low back pain (LBP) is one of the most common musculoskeletal symptoms and severely affects patient quality of life. The majority of people may suffer from LBP during their life-span, which leading to huge economic burdens to family and society. According to the series of the previous studies, intervertebral disc degeneration (IDD) is considered as the major contributor resulting in LBP. Furthermore, non-coding RNAs (ncRNAs), mainly including microRNAs (miRNAs), long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs), can regulate diverse cellular processes, which have been found to play pivotal roles in the development of IDD. However, the potential mechanisms of action for ncRNAs in the processes of IDD are still completely unrevealed. Therefore, it is challenging to consider ncRNAs to be used as the potential therapeutic targets for IDD. In this paper, we reviewed the current research progress and findings on ncRNAs in IDD: i). ncRNAs mainly participate in the process of IDD through regulating apoptosis of nucleus pulposus (NP) cells, metabolism of extracellular matrix (ECM) and inflammatory response; ii). the roles of miRNAs/lncRNAs/circRNAs are cross-talk in IDD development, which is similar to the network and can modulate each other; iii). ncRNAs have been attempted to combat the degenerative processes and may be promising as an efficient bio-therapeutic strategy in the future. Hence, this review systematically summarizes the principal pathomechanisms of IDD and shed light on the therapeutic potentials of ncRNAs in IDD.

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Jiang C. et al. The potential mechanisms and application prospects of non-coding RNAs in intervertebral disc degeneration // Frontiers in Endocrinology. 2022. Vol. 13.
GOST all authors (up to 50) Copy
Jiang C., Chen Z., Wang X., Zhang Y., Guo X., Xu Z., Yang H., Hao D. The potential mechanisms and application prospects of non-coding RNAs in intervertebral disc degeneration // Frontiers in Endocrinology. 2022. Vol. 13.
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RIS Copy
TY - JOUR
DO - 10.3389/fendo.2022.1081185
UR - https://doi.org/10.3389/fendo.2022.1081185
TI - The potential mechanisms and application prospects of non-coding RNAs in intervertebral disc degeneration
T2 - Frontiers in Endocrinology
AU - Jiang, Chao
AU - Chen, Zhe
AU - Wang, Xiaohui
AU - Zhang, Yongyuan
AU - Guo, Xinyu
AU - Xu, Zhengwei
AU - Yang, Hao
AU - Hao, Dingjun
PY - 2022
DA - 2022/12/08
PB - Frontiers Media S.A.
VL - 13
SN - 1664-2392
ER -
BibTex
Cite this
BibTex (up to 50 authors) Copy
@article{2022_Jiang,
author = {Chao Jiang and Zhe Chen and Xiaohui Wang and Yongyuan Zhang and Xinyu Guo and Zhengwei Xu and Hao Yang and Dingjun Hao},
title = {The potential mechanisms and application prospects of non-coding RNAs in intervertebral disc degeneration},
journal = {Frontiers in Endocrinology},
year = {2022},
volume = {13},
publisher = {Frontiers Media S.A.},
month = {dec},
url = {https://doi.org/10.3389/fendo.2022.1081185},
doi = {10.3389/fendo.2022.1081185}
}
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