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Frontiers in Molecular Biosciences, volume 8

Functional Diversity of Mitochondrial Peptidyl-tRNA Hydrolase ICT1 in Human Cells

Chicherin I V ^{1, 2}

Dukhalin S V ¹

Khannanov R A ¹

Baleva M. V. ¹

Levitskii S A ¹

Patrushev M V ²

Sergiev P V ^{3, 4, 5, 6}

Kamenski P ¹

Hide authors affiliations Show authors affiliations: 6 affiliations

Department of Molecular Biology, M.V.Lomonosov Moscow State University, Russia |

National Research Center ""Kurchatov Institute"", NBICS Center, Russia |

Belozersky Institute of Physico-chemical Biology, Lomonosov Moscow State University, Russia |

⁴

Center of Life Sciences, Skolkovo Institute of Science and Technology, Russia |

⁵

Department of Chemistry, Lomonosov Moscow State University, Russia |

⁶

Institute of Functional Genomics, Lomonosov Moscow State University, Russia |

Publication type: Journal Article

Publication date: 2021-07-16

Frontiers Media S.A.

Journal: Frontiers in Molecular Biosciences

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Impact factor: 5

ISSN: 2296889X

DOI: 10.3389/fmolb.2021.716885

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PubMed ID: 34336930

Biochemistry

Molecular Biology

Biochemistry, Genetics and Molecular Biology (miscellaneous)

Abstract

Mitochondria are energy producing organelles of the eukaryotic cell, involved in the synthesis of key metabolites, calcium homeostasis and apoptosis. Protein biosynthesis in these organelles is a relic of its endosymbiotic origin. While mitochondrial translational factors have homologues among prokaryotes, they possess a number of unique traits. Remarkably as many as four mammalian mitochondrial proteins possess a clear similarity with translation termination factors. The review focuses on the ICT1, which combines several functions. It is a non-canonical termination factor for protein biosynthesis, a rescue factor for stalled mitochondrial ribosomes, a structural protein and a regulator of proliferation, cell cycle, and apoptosis. Such a diversity of roles demonstrates the high functionality of mitochondrial translation associated proteins and their relationship with numerous processes occurring in a living cell.

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	1
Methods in Molecular Biology	Methods in Molecular Biology, 1, 25% Methods in Molecular Biology 1 publication, 25%
Future Journal of Pharmaceutical Sciences	Future Journal of Pharmaceutical Sciences, 1, 25% Future Journal of Pharmaceutical Sciences 1 publication, 25%
IUBMB Life	IUBMB Life, 1, 25% IUBMB Life 1 publication, 25%
Molecular Biology of the Cell	Molecular Biology of the Cell, 1, 25% Molecular Biology of the Cell 1 publication, 25%
	1

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	1 2
Springer Nature	Springer Nature, 2, 50% Springer Nature 2 publications, 50%
Wiley	Wiley, 1, 25% Wiley 1 publication, 25%
American Society for Cell Biology (ASCB)	American Society for Cell Biology (ASCB), 1, 25% American Society for Cell Biology (ASCB) 1 publication, 25%
	1 2

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Chicherin I. V. et al. Functional Diversity of Mitochondrial Peptidyl-tRNA Hydrolase ICT1 in Human Cells // Frontiers in Molecular Biosciences. 2021. Vol. 8.

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Chicherin I. V., Dukhalin S. V., Khannanov R. A., Baleva M. V., Levitskii S. A., Patrushev M. V., Sergiev P. V., Kamenski P. Functional Diversity of Mitochondrial Peptidyl-tRNA Hydrolase ICT1 in Human Cells // Frontiers in Molecular Biosciences. 2021. Vol. 8.

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RIS Copy

TY - JOUR

DO - 10.3389/fmolb.2021.716885

UR - https://doi.org/10.3389%2Ffmolb.2021.716885

TI - Functional Diversity of Mitochondrial Peptidyl-tRNA Hydrolase ICT1 in Human Cells

T2 - Frontiers in Molecular Biosciences

AU - Chicherin, I V

AU - Dukhalin, S V

AU - Khannanov, R A

AU - Baleva, M. V.

AU - Levitskii, S A

AU - Patrushev, M V

AU - Sergiev, P V

AU - Kamenski, P

PY - 2021

DA - 2021/07/16 00:00:00

PB - Frontiers Media S.A.

VL - 8

PMID - 34336930

SN - 2296-889X

ER -

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@article{2021_Chicherin,

author = {I V Chicherin and S V Dukhalin and R A Khannanov and M. V. Baleva and S A Levitskii and M V Patrushev and P V Sergiev and P Kamenski},

title = {Functional Diversity of Mitochondrial Peptidyl-tRNA Hydrolase ICT1 in Human Cells},

journal = {Frontiers in Molecular Biosciences},

year = {2021},

volume = {8},

publisher = {Frontiers Media S.A.},

month = {jul},

url = {https://doi.org/10.3389%2Ffmolb.2021.716885},

doi = {10.3389/fmolb.2021.716885}

}

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Publisher

Frontiers Media S.A.

Journal

Frontiers in Molecular Biosciences

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Quartile WOS

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2296889X (Electronic)

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Sergiev, Petr V