Open Access
Frontiers in Oncology, volume 11
Alpha-Fetoprotein Binding Mucin and Scavenger Receptors: An Available Bio-Target for Treating Cancer
1
Hainan Provincial Key Laboratory of Carcinogenesis and Intervention, Hainan Medical College, China
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2
Institution of Tumor, Hainan Medical College, China
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Publication type: Journal Article
Publication date: 2021-02-25
Journal:
Frontiers in Oncology
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 4.7
ISSN: 2234943X
PubMed ID:
33718192
Cancer Research
Oncology
Abstract
Alpha-fetoprotein (AFP) entrance into cancer cells is mediated by AFP receptors (AFPRs) and exerts malignant effects. Therefore, understanding the structure of AFPRs will facilitate the development of rational approaches for vaccine design, drug delivery, antagonizing immune suppression and diagnostic imaging to treat cancer effectively. Throughout the last three decades, the identification of universal receptors for AFP has failed due to their complex carbohydrate polymer structures. Here, we focused on the two types of binding proteins or receptors that may serve as AFPRs, namely, the A) mucin receptors family, and B) the scavenger family. We presented an informative review with detailed descriptions of the signal transduction, cross-talk, and interplay of various transcription factors which highlight the downstream events following AFP binding to mucin or scavenger receptors. We mainly explored the underlying mechanisms involved mucin or scavenger receptors that interact with AFP, provide more evidence to support these receptors as tumor AFPRs, and establish a theoretical basis for targeting therapy of cancer.
Citations by journals
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1
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Biotekhnologiya
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Biotekhnologiya, 1, 16.67%
Biotekhnologiya
1 publication, 16.67%
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Applied Biochemistry and Microbiology
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Applied Biochemistry and Microbiology
1 publication, 16.67%
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
1 publication, 16.67%
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Liver Cancer
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Liver Cancer
1 publication, 16.67%
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Clinical and Experimental Medicine
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Clinical and Experimental Medicine
1 publication, 16.67%
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Cancer Cell International
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Cancer Cell International
1 publication, 16.67%
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1
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Citations by publishers
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1
2
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Springer Nature
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Springer Nature
2 publications, 33.33%
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State Research Institute for Genetics and Selection of Industrial Microorganisms
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State Research Institute for Genetics and Selection of Industrial Microorganisms, 1, 16.67%
State Research Institute for Genetics and Selection of Industrial Microorganisms
1 publication, 16.67%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 16.67%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 16.67%
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S. Karger AG
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S. Karger AG
1 publication, 16.67%
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1
2
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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GOST
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Lin B. et al. Alpha-Fetoprotein Binding Mucin and Scavenger Receptors: An Available Bio-Target for Treating Cancer // Frontiers in Oncology. 2021. Vol. 11.
GOST all authors (up to 50)
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Lin B., Wang Q., Liu K., Dong Xu, Zhu M., Li M. Alpha-Fetoprotein Binding Mucin and Scavenger Receptors: An Available Bio-Target for Treating Cancer // Frontiers in Oncology. 2021. Vol. 11.
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TY - JOUR
DO - 10.3389/fonc.2021.625936
UR - https://doi.org/10.3389%2Ffonc.2021.625936
TI - Alpha-Fetoprotein Binding Mucin and Scavenger Receptors: An Available Bio-Target for Treating Cancer
T2 - Frontiers in Oncology
AU - Lin, Bo
AU - Wang, Qiujiao
AU - Liu, Kun
AU - Dong Xu
AU - Zhu, Mingyue
AU - Li, Mengsen
PY - 2021
DA - 2021/02/25 00:00:00
PB - Frontiers Media S.A.
VL - 11
PMID - 33718192
SN - 2234-943X
ER -
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@article{2021_Lin,
author = {Bo Lin and Qiujiao Wang and Kun Liu and Dong Xu and Mingyue Zhu and Mengsen Li},
title = {Alpha-Fetoprotein Binding Mucin and Scavenger Receptors: An Available Bio-Target for Treating Cancer},
journal = {Frontiers in Oncology},
year = {2021},
volume = {11},
publisher = {Frontiers Media S.A.},
month = {feb},
url = {https://doi.org/10.3389%2Ffonc.2021.625936},
doi = {10.3389/fonc.2021.625936}
}