Open Access
Applied Sciences (Switzerland), volume 9, issue 9, pages 1918
Towards Bimodal Optical Monitoring of Photodynamic Therapy with Targeted Nanoconstructs: A Phantom Study
Kurakina Daria
1
,
Kirillin Mikhail
1
,
Perekatova Valeriya
1
,
Orlova Anna
1
,
Sergeeva Ekaterina
1
,
Khilov Aleksandr
1
,
Nerush Anastasiya
1
,
Subochev Pavel
1
,
Mallidi Srivalleesha
2, 3
,
Turchin Il'ya V.
1
,
Hasan Tayyaba
2
2
Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
|
3
Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA
|
Publication type: Journal Article
Publication date: 2019-05-10
Journal:
Applied Sciences (Switzerland)
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 2.7
ISSN: 20763417
Computer Science Applications
Process Chemistry and Technology
General Materials Science
Instrumentation
General Engineering
Fluid Flow and Transfer Processes
Abstract
Increase of the efficiency of photodynamic therapy (PDT) requires the development of advanced protocols employing both novel photosensitizer (PS) carriers and aids for online monitoring. Nanoconstructs may be comprised of a photosensitizer, chemotherapy drugs, or inhibitors of molecular pathways that support cancer growth. In this paper, we analyze the efficiency of a bimodal approach involving fluorescence and optoacoustic imaging in monitoring drug distribution and photobleaching. The study evaluates typical sensitivities of these techniques to the presence of the two key moieties of a nanoconstruct: benzoporphyrin derivatives (BPD) serving as a PS, and IRDye800 acting as a contrast agent. Both imaging modalities employ dual-wavelength probing at the wavelengths corresponding to absorption peaks of BPD and IRDye800, which enables their separate detection. In an experiment on a tissue-mimicking phantom with inclusions containing separate BPD and IRDye800 solutions, fluorescence imaging demonstrated higher contrast as compared to optoacoustic imaging for both components, though strong light scattering in the surrounding media restricted accurate localization of the markers. It was also sensitive to photobleaching, which is a measure of PDT efficiency. Optoacoustic imaging demonstrated sufficient sensitivity to both components, though less than that of fluorescence imaging, however, it enabled depth-resolved detection of an absorber and estimation of its relative content. Employment of the bimodal approach in monitoring of PS photobleaching adds to its potential in intraprocedural PDT monitoring.
Citations by journals
|
1
2
3
|
|
|
Laser Physics Letters
|
Laser Physics Letters
3 publications, 30%
|
|
Progress in Biomedical Optics and Imaging - Proceedings of SPIE
|
Progress in Biomedical Optics and Imaging - Proceedings of SPIE
2 publications, 20%
|
|
Sensors
|
Sensors
1 publication, 10%
|
|
Biomedical Optics Express
|
Biomedical Optics Express
1 publication, 10%
|
|
Cancers
|
Cancers
1 publication, 10%
|
|
Optics and Spectroscopy (English translation of Optika i Spektroskopiya)
|
Optics and Spectroscopy (English translation of Optika i Spektroskopiya)
1 publication, 10%
|
|
1
2
3
|
Citations by publishers
|
1
2
3
|
|
|
IOP Publishing
|
IOP Publishing
3 publications, 30%
|
|
Multidisciplinary Digital Publishing Institute (MDPI)
|
Multidisciplinary Digital Publishing Institute (MDPI)
2 publications, 20%
|
|
SPIE
|
SPIE
2 publications, 20%
|
|
Optical Society of America
|
Optical Society of America
1 publication, 10%
|
|
Pleiades Publishing
|
Pleiades Publishing
1 publication, 10%
|
|
1
2
3
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2020,2021,2022,2023,2024],"ids":[0,0,0,0,0],"codes":[0,0,0,0,0],"imageUrls":["","","","",""],"datasets":[{"label":"Citations number","data":[4,4,1,0,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["40","40","10",0,"10"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Laser Physics Letters","Progress in Biomedical Optics and Imaging - Proceedings of SPIE","Sensors","Biomedical Optics Express","Cancers","Optics and Spectroscopy (English translation of Optika i Spektroskopiya)"],"ids":[3077,24727,18435,14292,22471,16531],"codes":[0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/LsKy6OnmmmRGcAU6CZgWQvNiP1polbaSLNrN7zqj_medium.webp","\/storage\/images\/resized\/DBpVkewJngs3BK2gVqHayOcCZf2Czbxddw6ObU26_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/bypZPcr6C4twKiQVCUCGc0GF4cH6aUWmpClD3hsH_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp"],"datasets":[{"label":"","data":[3,2,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[30,20,10,10,10,10],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["IOP Publishing","Multidisciplinary Digital Publishing Institute (MDPI)","SPIE","Optical Society of America","Pleiades Publishing"],"ids":[2075,202,7162,375,101],"codes":[0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/LsKy6OnmmmRGcAU6CZgWQvNiP1polbaSLNrN7zqj_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/DBpVkewJngs3BK2gVqHayOcCZf2Czbxddw6ObU26_medium.webp","\/storage\/images\/resized\/bypZPcr6C4twKiQVCUCGc0GF4cH6aUWmpClD3hsH_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp"],"datasets":[{"label":"","data":[3,2,2,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[30,20,20,10,10],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Metrics
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Kurakina D. et al. Towards Bimodal Optical Monitoring of Photodynamic Therapy with Targeted Nanoconstructs: A Phantom Study // Applied Sciences (Switzerland). 2019. Vol. 9. No. 9. p. 1918.
GOST all authors (up to 50)
Copy
Kurakina D., Kirillin M., Perekatova V., Plekhanov V., Orlova A., Sergeeva E., Khilov A., Nerush A., Subochev P., Mallidi S., Turchin I. V., Hasan T. Towards Bimodal Optical Monitoring of Photodynamic Therapy with Targeted Nanoconstructs: A Phantom Study // Applied Sciences (Switzerland). 2019. Vol. 9. No. 9. p. 1918.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3390/app9091918
UR - https://doi.org/10.3390%2Fapp9091918
TI - Towards Bimodal Optical Monitoring of Photodynamic Therapy with Targeted Nanoconstructs: A Phantom Study
T2 - Applied Sciences (Switzerland)
AU - Kirillin, Mikhail
AU - Perekatova, Valeriya
AU - Orlova, Anna
AU - Sergeeva, Ekaterina
AU - Khilov, Aleksandr
AU - Nerush, Anastasiya
AU - Subochev, Pavel
AU - Mallidi, Srivalleesha
AU - Hasan, Tayyaba
AU - Kurakina, Daria
AU - Plekhanov, Vladimir
AU - Turchin, Il'ya V.
PY - 2019
DA - 2019/05/10 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 1918
IS - 9
VL - 9
SN - 2076-3417
ER -
Cite this
BibTex
Copy
@article{2019_Kurakina,
author = {Mikhail Kirillin and Valeriya Perekatova and Anna Orlova and Ekaterina Sergeeva and Aleksandr Khilov and Anastasiya Nerush and Pavel Subochev and Srivalleesha Mallidi and Tayyaba Hasan and Daria Kurakina and Vladimir Plekhanov and Il'ya V. Turchin},
title = {Towards Bimodal Optical Monitoring of Photodynamic Therapy with Targeted Nanoconstructs: A Phantom Study},
journal = {Applied Sciences (Switzerland)},
year = {2019},
volume = {9},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {may},
url = {https://doi.org/10.3390%2Fapp9091918},
number = {9},
pages = {1918},
doi = {10.3390/app9091918}
}
Cite this
MLA
Copy
Kurakina, Daria, et al. “Towards Bimodal Optical Monitoring of Photodynamic Therapy with Targeted Nanoconstructs: A Phantom Study.” Applied Sciences (Switzerland), vol. 9, no. 9, May. 2019, p. 1918. https://doi.org/10.3390%2Fapp9091918.