Open Access
Open access
MDPI
Biomolecules
,  volume 13 ,  issue 7 ,  pages 1053

Improving the Stability and Effectiveness of Immunotropic Squalene Nanoemulsion by Adding Turpentine Oil

Olga A. Krasnova 1, 2
, 
Vladislav V. Minaychev 1
, 
Vladimir S. Akatov 1
, 
Roman S. Fadeev 1, 2
, 
Anatoliy S. Senotov 1
, 
Margarita I. Kobyakova 1
, 
Yana V. Lomovskaya 1
, 
Alexey I. Lomovskiy 1
, 
Alyona I. Zvyagina 1
, 
Kirill Krasnov 1, 2
, 
Yuriy V. Shatalin 1
, 
Nikita V. Penkov 3
, 
Vitaly K Zhalimov 1, 3
, 
Maxim V. Molchanov 1
, 
Yulia A Palikova 4
, 
Arkady N Murashev 2, 4
, 
Eugeny I. Maevsky 1
, 
Irina S. Fadeeva 1, 2
1
 
2
 
3
 
4
 
Publication type: Journal Article
Publication date: 2023-06-29
MDPI
scimago Q1
wos Q1
SJR: 1.333
CiteScore: 9.2
Impact factor: 4.8
ISSN: 2218273X
DOI:  10.3390/biom13071053
PubMed ID:  37509089
Biochemistry
Molecular Biology
Abstract

Turpentine oil, owing to the presence of 7–50 terpenes, has analgesic, anti-inflammatory, immunomodulatory, antibacterial, anticoagulant, antioxidant, and antitumor properties, which are important for medical emulsion preparation. The addition of turpentine oil to squalene emulsions can increase their effectiveness, thereby reducing the concentration of expensive and possibly deficient squalene, and increasing its stability and shelf life. In this study, squalene emulsions were obtained by adding various concentrations of turpentine oil via high-pressure homogenization, and the safety and effectiveness of the obtained emulsions were studied in vitro and in vivo. All emulsions showed high safety profiles, regardless of the concentration of turpentine oil used. However, these emulsions exhibited dose-dependent effects in terms of both efficiency and storage stability, and the squalene emulsion with 1.0% turpentine oil had the most pronounced adjuvant and cytokine-stimulating activity as well as the most pronounced stability indicators when stored at room temperature. Thus, it can be concluded that the squalene emulsion with 1% turpentine oil is a stable, monomodal, and reliably safe ultradispersed emulsion and may have pleiotropic effects with pronounced immunopotentiating properties.

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Krasnova O. A. et al. Improving the Stability and Effectiveness of Immunotropic Squalene Nanoemulsion by Adding Turpentine Oil // Biomolecules. 2023. Vol. 13. No. 7. p. 1053.
GOST all authors (up to 50) Copy
Krasnova O. A., Minaychev V. V., Akatov V. S., Fadeev R. S., Senotov A. S., Kobyakova M. I., Lomovskaya Y. V., Lomovskiy A. I., Zvyagina A. I., Krasnov K., Shatalin Y. V., Penkov N. V., Zhalimov V. K., Molchanov M. V., Palikova Y. A., Murashev A. N., Maevsky E. I., Fadeeva I. S. Improving the Stability and Effectiveness of Immunotropic Squalene Nanoemulsion by Adding Turpentine Oil // Biomolecules. 2023. Vol. 13. No. 7. p. 1053.
RIS |
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RIS Copy
TY - JOUR
DO - 10.3390/biom13071053
UR - https://doi.org/10.3390/biom13071053
TI - Improving the Stability and Effectiveness of Immunotropic Squalene Nanoemulsion by Adding Turpentine Oil
T2 - Biomolecules
AU - Krasnova, Olga A.
AU - Minaychev, Vladislav V.
AU - Akatov, Vladimir S.
AU - Fadeev, Roman S.
AU - Senotov, Anatoliy S.
AU - Kobyakova, Margarita I.
AU - Lomovskaya, Yana V.
AU - Lomovskiy, Alexey I.
AU - Zvyagina, Alyona I.
AU - Krasnov, Kirill
AU - Shatalin, Yuriy V.
AU - Penkov, Nikita V.
AU - Zhalimov, Vitaly K
AU - Molchanov, Maxim V.
AU - Palikova, Yulia A
AU - Murashev, Arkady N
AU - Maevsky, Eugeny I.
AU - Fadeeva, Irina S.
PY - 2023
DA - 2023/06/29
PB - MDPI
SP - 1053
IS - 7
VL - 13
PMID - 37509089
SN - 2218-273X
ER -
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@article{2023_Krasnova,
author = {Olga A. Krasnova and Vladislav V. Minaychev and Vladimir S. Akatov and Roman S. Fadeev and Anatoliy S. Senotov and Margarita I. Kobyakova and Yana V. Lomovskaya and Alexey I. Lomovskiy and Alyona I. Zvyagina and Kirill Krasnov and Yuriy V. Shatalin and Nikita V. Penkov and Vitaly K Zhalimov and Maxim V. Molchanov and Yulia A Palikova and Arkady N Murashev and Eugeny I. Maevsky and Irina S. Fadeeva},
title = {Improving the Stability and Effectiveness of Immunotropic Squalene Nanoemulsion by Adding Turpentine Oil},
journal = {Biomolecules},
year = {2023},
volume = {13},
publisher = {MDPI},
month = {jun},
url = {https://doi.org/10.3390/biom13071053},
number = {7},
pages = {1053},
doi = {10.3390/biom13071053}
}
MLA
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Krasnova, Olga A., et al. “Improving the Stability and Effectiveness of Immunotropic Squalene Nanoemulsion by Adding Turpentine Oil.” Biomolecules, vol. 13, no. 7, Jun. 2023, p. 1053. https://doi.org/10.3390/biom13071053.