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Biomimetics, volume 8, issue 1, pages 91

Biomimetic Remineralized Three-Dimensional Collagen Bone Matrices with an Enhanced Osteostimulating Effect

Fadeeva Irina S. ^{1, 2}

Teterina Anastasia Yu. ²

Minaychev Vladislav V. ^{1, 2}

Senotov Anatoliy S. ¹

Smirnov Igor V. ²

Fadeev Roman S. ¹

Smirnova Polina V. ²

Menukhov Vladislav O. ¹

Lomovskaya Yana V. ¹

Akatov Vladimir S. ¹

Barinov Sergey M. ²

Komlev Vladimir S. ²

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Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino 142290, Russia |

Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Leninskiy Prospect 49, Moscow 117334, Russia |

Publication type: Journal Article

Publication date: 2023-02-23

Multidisciplinary Digital Publishing Institute (MDPI)

Journal: Biomimetics

Quartile SCImago

Quartile WOS

Impact factor: 4.5

ISSN: 23137673

DOI: 10.3390/biomimetics8010091

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PubMed ID: 36975321

Biochemistry

Molecular Medicine

Biotechnology

Bioengineering

Biomaterials

Biomedical Engineering

Abstract

Bone grafts with a high potential for osseointegration, capable of providing a complete and effective regeneration of bone tissue, remain an urgent and unresolved issue. The presented work proposes an approach to develop composite biomimetic bone material for reconstructive surgery by deposition (remineralization) on the surface of high-purity, demineralized bone collagen matrix calcium phosphate layers. Histological and elemental analysis have shown reproduction of the bone tissue matrix architectonics, and a high-purity degree of the obtained collagen scaffolds; the cell culture and confocal microscopy have demonstrated a high biocompatibility of the materials obtained. Adsorption spectroscopy, scanning electron microscopy, microcomputed tomography (microCT) and infrared spectroscopy, and X-ray diffraction have proven the efficiency of the deposition of calcium phosphates on the surface of bone collagen scaffolds. Cell culture and confocal microscopy methods have shown high biocompatibility of both demineralized and remineralized bone matrices. In the model of heterotopic implantation in rats, at the term of seven weeks, an intensive intratrabecular infiltration of calcium phosphate precipitates, and a pronounced synthetic activity of osteoblast remodeling and rebuilding implanted materials, were revealed in remineralized bone collagen matrices in contrast to demineralized ones. Thus, remineralization of highly purified demineralized bone matrices significantly enhanced their osteostimulating ability. The data obtained are of interest for the creation of new highly effective osteoplastic materials for bone tissue regeneration and augmentation.

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	1
Technologies	Technologies, 1, 25% Technologies 1 publication, 25%
Applied Sciences (Switzerland)	Applied Sciences (Switzerland), 1, 25% Applied Sciences (Switzerland) 1 publication, 25%
Biomedicines	Biomedicines, 1, 25% Biomedicines 1 publication, 25%
Journal of Functional Biomaterials	Journal of Functional Biomaterials, 1, 25% Journal of Functional Biomaterials 1 publication, 25%
	1

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Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 4, 100% Multidisciplinary Digital Publishing Institute (MDPI) 4 publications, 100%
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Fadeeva I. S. et al. Biomimetic Remineralized Three-Dimensional Collagen Bone Matrices with an Enhanced Osteostimulating Effect // Biomimetics. 2023. Vol. 8. No. 1. p. 91.

GOST all authors (up to 50) Copy

Fadeeva I. S., Teterina A. Y., Minaychev V. V., Senotov A. S., Smirnov I. V., Fadeev R. S., Smirnova P. V., Menukhov V. O., Lomovskaya Y. V., Akatov V. S., Barinov S. M., Komlev V. S. Biomimetic Remineralized Three-Dimensional Collagen Bone Matrices with an Enhanced Osteostimulating Effect // Biomimetics. 2023. Vol. 8. No. 1. p. 91.

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TY - JOUR

DO - 10.3390/biomimetics8010091

UR - https://doi.org/10.3390%2Fbiomimetics8010091

TI - Biomimetic Remineralized Three-Dimensional Collagen Bone Matrices with an Enhanced Osteostimulating Effect

T2 - Biomimetics

AU - Fadeeva, Irina S.

AU - Teterina, Anastasia Yu.

AU - Minaychev, Vladislav V.

AU - Senotov, Anatoliy S.

AU - Smirnov, Igor V.

AU - Fadeev, Roman S.

AU - Smirnova, Polina V.

AU - Menukhov, Vladislav O.

AU - Lomovskaya, Yana V.

AU - Akatov, Vladimir S.

AU - Barinov, Sergey M.

AU - Komlev, Vladimir S.

PY - 2023

DA - 2023/02/23 00:00:00

PB - Multidisciplinary Digital Publishing Institute (MDPI)

SP - 91

IS - 1

VL - 8

PMID - 36975321

SN - 2313-7673

ER -

BibTex |

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@article{2023_Fadeeva,

author = {Irina S. Fadeeva and Anastasia Yu. Teterina and Vladislav V. Minaychev and Anatoliy S. Senotov and Igor V. Smirnov and Roman S. Fadeev and Polina V. Smirnova and Vladislav O. Menukhov and Yana V. Lomovskaya and Vladimir S. Akatov and Sergey M. Barinov and Vladimir S. Komlev},

title = {Biomimetic Remineralized Three-Dimensional Collagen Bone Matrices with an Enhanced Osteostimulating Effect},

journal = {Biomimetics},

year = {2023},

volume = {8},

publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},

month = {feb},

url = {https://doi.org/10.3390%2Fbiomimetics8010091},

number = {1},

pages = {91},

doi = {10.3390/biomimetics8010091}

}

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Fadeeva, Irina S., et al. “Biomimetic Remineralized Three-Dimensional Collagen Bone Matrices with an Enhanced Osteostimulating Effect.” Biomimetics, vol. 8, no. 1, Feb. 2023, p. 91. https://doi.org/10.3390%2Fbiomimetics8010091.

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Publisher

Multidisciplinary Digital Publishing Institute (MDPI)

Journal

Biomimetics

Quartile SCImago

Quartile WOS

Impact factor

4.5

ISSN

23137673 (Electronic)

Labs

Laboratory of Biomedical Technologies

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