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Biomimetics

, том 8 , издание 2 , страницы 230

A Novel Anthropomorphic Phantom Composed of Tissue-Equivalent Materials for Use in Experimental Radiotherapy: Design, Dosimetry and Biological Pilot Study

Thomas Breslin ¹

Jason R. Paino ²

Marie Wegner ³

Elette Engels ^{2, 4}

Stefan Fiedler ⁵

Helen Forrester ⁶

Hannes Rennau ⁷

John Bustillo ²

Matthew Cameron ⁴

Daniel Häusermann ⁴

Christopher Hall ⁴

Dieter Krause ³

Guido Hildebrandt ⁷

Michael Lerch ²

Elisabeth Schültke ⁷

Скрыть аффилиации авторов Показать аффилиации авторов: 7 аффилиаций

Department of Oncology, Clinical Sciences, Lund University, 22185 Lund, Sweden |

Centre of Medical Radiation Physics, University of Wollongong, Wollongong 2522, Australia |

Institute of Product Development and Mechanical Engineering Design, Hamburg University of Technology, 21073 Hamburg, Germany |

⁴

Australian Synchrotron/ANSTO, Clayton 3168, Australia |

⁵

European Molecular Biology Laboratory (EMBL), Hamburg Outstation, 22607 Hamburg, Germany |

⁶

School of Science, Royal Melbourne Institute of Technology (RMIT) University, Melbourne 3001, Australia |

⁷

Department of Radiooncology, Rostock University Medical Center, 18059 Rostock, Germany |

Тип публикации: Journal Article

Дата публикации: 2023-05-31

MDPI

Biomimetics

scimago Q2

wos Q1

БС3

SJR: 0.647

CiteScore: 4.2

Impact factor: 3.9

ISSN: 23137673

DOI: 10.3390/biomimetics8020230

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PubMed ID: 37366825

Biochemistry

Molecular Medicine

Biotechnology

Bioengineering

Biomaterials

Biomedical Engineering

Краткое описание

The production of anthropomorphic phantoms generated from tissue-equivalent materials is challenging but offers an excellent copy of the typical environment encountered in typical patients. High-quality dosimetry measurements and the correlation of the measured dose with the biological effects elicited by it are a prerequisite in preparation of clinical trials with novel radiotherapy approaches. We designed and produced a partial upper arm phantom from tissue-equivalent materials for use in experimental high-dose-rate radiotherapy. The phantom was compared to original patient data using density values and Hounsfield units obtained from CT scans. Dose simulations were conducted for broad-beam irradiation and microbeam radiotherapy (MRT) and compared to values measured in a synchrotron radiation experiment. Finally, we validated the phantom in a pilot experiment with human primary melanoma cells.

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Васильев Юрий

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Научно-практический клинический центр диагностики и телемедицинских технологий Департамента здравоохранения города Москвы

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Искусственный интеллект

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31 публикация, 132 цитирования

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Омельянская Ольга

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Черкасская Марина

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Biomedical Physics and Engineering Express	Biomedical Physics and Engineering Express, 2, 16.67% Biomedical Physics and Engineering Express 2 публикации, 16.67%
Biomimetics	Biomimetics, 2, 16.67% Biomimetics 2 публикации, 16.67%
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Physics in Medicine and Biology	Physics in Medicine and Biology, 1, 8.33% Physics in Medicine and Biology 1 публикация, 8.33%
Bioengineering	Bioengineering, 1, 8.33% Bioengineering 1 публикация, 8.33%
Journal of Mechanical Science and Technology	Journal of Mechanical Science and Technology, 1, 8.33% Journal of Mechanical Science and Technology 1 публикация, 8.33%
Scientific Reports	Scientific Reports, 1, 8.33% Scientific Reports 1 публикация, 8.33%
Chinese Clinical Oncology	Chinese Clinical Oncology, 1, 8.33% Chinese Clinical Oncology 1 публикация, 8.33%
Journal of Medical Signals and Sensors	Journal of Medical Signals and Sensors, 1, 8.33% Journal of Medical Signals and Sensors 1 публикация, 8.33%
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Breslin T. et al. A Novel Anthropomorphic Phantom Composed of Tissue-Equivalent Materials for Use in Experimental Radiotherapy: Design, Dosimetry and Biological Pilot Study // Biomimetics. 2023. Vol. 8. No. 2. p. 230.

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Breslin T., Paino J. R., Wegner M., Engels E., Fiedler S., Forrester H., Rennau H., Bustillo J., Cameron M., Häusermann D., Hall C., Krause D., Hildebrandt G., Lerch M., Schültke E. A Novel Anthropomorphic Phantom Composed of Tissue-Equivalent Materials for Use in Experimental Radiotherapy: Design, Dosimetry and Biological Pilot Study // Biomimetics. 2023. Vol. 8. No. 2. p. 230.

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TY - JOUR

DO - 10.3390/biomimetics8020230

UR - https://doi.org/10.3390/biomimetics8020230

TI - A Novel Anthropomorphic Phantom Composed of Tissue-Equivalent Materials for Use in Experimental Radiotherapy: Design, Dosimetry and Biological Pilot Study

T2 - Biomimetics

AU - Breslin, Thomas

AU - Paino, Jason R.

AU - Wegner, Marie

AU - Engels, Elette

AU - Fiedler, Stefan

AU - Forrester, Helen

AU - Rennau, Hannes

AU - Bustillo, John

AU - Cameron, Matthew

AU - Häusermann, Daniel

AU - Hall, Christopher

AU - Krause, Dieter

AU - Hildebrandt, Guido

AU - Lerch, Michael

AU - Schültke, Elisabeth

PY - 2023

DA - 2023/05/31

PB - MDPI

SP - 230

IS - 2

VL - 8

PMID - 37366825

SN - 2313-7673

ER -

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@article{2023_Breslin,

author = {Thomas Breslin and Jason R. Paino and Marie Wegner and Elette Engels and Stefan Fiedler and Helen Forrester and Hannes Rennau and John Bustillo and Matthew Cameron and Daniel Häusermann and Christopher Hall and Dieter Krause and Guido Hildebrandt and Michael Lerch and Elisabeth Schültke},

title = {A Novel Anthropomorphic Phantom Composed of Tissue-Equivalent Materials for Use in Experimental Radiotherapy: Design, Dosimetry and Biological Pilot Study},

journal = {Biomimetics},

year = {2023},

volume = {8},

publisher = {MDPI},

month = {may},

url = {https://doi.org/10.3390/biomimetics8020230},

number = {2},

pages = {230},

doi = {10.3390/biomimetics8020230}

}

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Breslin, Thomas, et al. “A Novel Anthropomorphic Phantom Composed of Tissue-Equivalent Materials for Use in Experimental Radiotherapy: Design, Dosimetry and Biological Pilot Study.” Biomimetics, vol. 8, no. 2, May. 2023, p. 230. https://doi.org/10.3390/biomimetics8020230.

Издатель

MDPI

Журнал

Biomimetics

scimago Q2

wos Q1

БС3

SJR

0.647

CiteScore

4.2

Impact factor

3.9

ISSN

23137673 (Electronic)

Профили

Енгелс Елетте Е