Open Access
Brain Sciences, volume 12, issue 5, pages 614
Evaluation of Approach to a Conspecific and Blood Biochemical Parameters in TAAR1 Knockout Mice
Zhukov Ilya S
1, 2
,
Ptukha Maria A
1
,
Zolotoverkhaya Ekaterina A.
3
,
Sinitca Ekaterina L
2
,
Tissen Ilya Y
2
,
Karpova Inessa V
2
,
Volnova Anna B.
1
,
GAINETDINOV RAUL R.
1, 4
Publication type: Journal Article
Publication date: 2022-05-08
General Neuroscience
Abstract
It is known that the trace amine-associated receptor 1 (TAAR1) receptor is involved in limbic brain functions by regulating dopamine transmission and putative reward circuitry. Moreover, other TAARs are expressed in the olfactory system of all studied vertebrate species, sensing innate socially-relevant odors, including pheromones. Therefore, one can assume that TAARs may play a role in rodent social and sexual behavior. A comparative behavioral and biochemical analysis of TAAR1 knockout (TAAR1-KO) and wild-type mice is also important for the preliminary evaluation of the potential side effects of future TAAR1-based therapies. In our studies, we adapted a sexual incentive motivation test for mice to evaluate the sexual behavior of TAAR1-KO and wild-type mice. Previously, similar methods were primarily applied to rats. Furthermore, we measured testosterone and other biochemical parameters in the blood. As a result, we found only minimal alterations in all of the studied parameters. Thus, the lack of TAAR1 does not significantly affect sexual motivation and routine lipid and metabolic blood biochemical parameters, suggesting that future TAAR1-based therapies should have a favorable safety profile.
Citations by journals
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Biomolecules
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Biomolecules
1 publication, 25%
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
1 publication, 25%
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Neurology International
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Neurology International
1 publication, 25%
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Current Drug Discovery Technologies
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Current Drug Discovery Technologies
1 publication, 25%
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1
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Citations by publishers
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2
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
2 publications, 50%
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PagePress
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PagePress
1 publication, 25%
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Bentham Science
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Bentham Science
1 publication, 25%
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1
2
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Zhukov I. S. et al. Evaluation of Approach to a Conspecific and Blood Biochemical Parameters in TAAR1 Knockout Mice // Brain Sciences. 2022. Vol. 12. No. 5. p. 614.
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Zhukov I. S., Ptukha M. A., Zolotoverkhaya E. A., Sinitca E. L., Tissen I. Y., Karpova I. V., Volnova A. B., GAINETDINOV R. R. Evaluation of Approach to a Conspecific and Blood Biochemical Parameters in TAAR1 Knockout Mice // Brain Sciences. 2022. Vol. 12. No. 5. p. 614.
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TY - JOUR
DO - 10.3390/brainsci12050614
UR - https://doi.org/10.3390%2Fbrainsci12050614
TI - Evaluation of Approach to a Conspecific and Blood Biochemical Parameters in TAAR1 Knockout Mice
T2 - Brain Sciences
AU - Zhukov, Ilya S
AU - Ptukha, Maria A
AU - Sinitca, Ekaterina L
AU - Tissen, Ilya Y
AU - GAINETDINOV, RAUL R.
AU - Zolotoverkhaya, Ekaterina A.
AU - Karpova, Inessa V
AU - Volnova, Anna B.
PY - 2022
DA - 2022/05/08 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 614
IS - 5
VL - 12
SN - 2076-3425
ER -
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@article{2022_Zhukov,
author = {Ilya S Zhukov and Maria A Ptukha and Ekaterina L Sinitca and Ilya Y Tissen and RAUL R. GAINETDINOV and Ekaterina A. Zolotoverkhaya and Inessa V Karpova and Anna B. Volnova},
title = {Evaluation of Approach to a Conspecific and Blood Biochemical Parameters in TAAR1 Knockout Mice},
journal = {Brain Sciences},
year = {2022},
volume = {12},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {may},
url = {https://doi.org/10.3390%2Fbrainsci12050614},
number = {5},
pages = {614},
doi = {10.3390/brainsci12050614}
}
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Zhukov, Ilya S., et al. “Evaluation of Approach to a Conspecific and Blood Biochemical Parameters in TAAR1 Knockout Mice.” Brain Sciences, vol. 12, no. 5, May. 2022, p. 614. https://doi.org/10.3390%2Fbrainsci12050614.