Open Access
Cancers, volume 12, issue 1, pages 216
Aptamer-Conjugated Superparamagnetic Ferroarabinogalactan Nanoparticles for Targeted Magnetodynamic Therapy of Cancer
Kolovskaya Olga S
1, 2
,
Zamay Tatiana N.
1
,
Zamay Galina S
1, 2
,
Babkin Vasily A
3
,
Medvedeva Elena N
3
,
Neverova Nadezhda A
3
,
Kirichenko Andrey K.
1
,
Zamay Sergey S
2, 4
,
Lapin Ivan N
5
,
Morozov E. V.
4, 6
,
Sokolov Alexey E
4, 7
,
Narodov Andrey A
1
,
Fedorov D. V.
8
,
Tomilin Felix N.
2, 4, 9
,
Zabluda Vladimir N
4
,
Alekhina Yulia
10
,
Lukyanenko Kirill A.
1, 2, 11
,
Glazyrin Yury E.
1, 2
,
Berezovski Maxim V.
12
,
Kichkailo Anna S.
1, 2
8
Research Center for Computational Design of Advanced Functional Materials (CD-FMat), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba 305-8568, Japan
|
12
Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada
|
Publication type: Journal Article
Publication date: 2020-01-15
PubMed ID:
31952299
Cancer Research
Oncology
Abstract
Nanotechnologies involving physical methods of tumor destruction using functional oligonucleotides are promising for targeted cancer therapy. Our study presents magnetodynamic therapy for selective elimination of tumor cells in vivo using DNA aptamer-functionalized magnetic nanoparticles exposed to a low frequency alternating magnetic field. We developed an enhanced targeting approach of cancer cells with aptamers and arabinogalactan. Aptamers to fibronectin (AS-14) and heat shock cognate 71 kDa protein (AS-42) facilitated the delivery of the nanoparticles to Ehrlich carcinoma cells, and arabinogalactan (AG) promoted internalization through asialoglycoprotein receptors. Specific delivery of the aptamer-modified FeAG nanoparticles to the tumor site was confirmed by magnetic resonance imaging (MRI). After the following treatment with a low frequency alternating magnetic field, AS-FeAG caused cancer cell death in vitro and tumor reduction in vivo. Histological analyses showed mechanical disruption of tumor tissues, total necrosis, cell lysis, and disruption of the extracellular matrix. The enhanced targeted magnetic theranostics with the aptamer conjugated superparamagnetic ferroarabinogalactans opens up a new venue for making biocompatible contrasting agents for MRI imaging and performing non-invasive anti-cancer therapies with a deep penetrated magnetic field.
Citations by journals
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Materials
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Materials
2 publications, 8%
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Magnetochemistry
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Magnetochemistry
2 publications, 8%
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ACS Applied Nano Materials
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ACS Applied Nano Materials
1 publication, 4%
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Biomedicines
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Biomedicines
1 publication, 4%
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Journal of Chemical Physics
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Journal of Chemical Physics
1 publication, 4%
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Nucleic Acid Therapeutics
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Nucleic Acid Therapeutics
1 publication, 4%
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
1 publication, 4%
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Pharmaceutics
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Pharmaceutics
1 publication, 4%
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Journal of Clinical Medicine
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Journal of Clinical Medicine
1 publication, 4%
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Journal of Functional Biomaterials
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Journal of Functional Biomaterials
1 publication, 4%
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Biosensors and Bioelectronics: X
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Biosensors and Bioelectronics: X
1 publication, 4%
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Biomedical Materials (Bristol)
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Biomedical Materials (Bristol)
1 publication, 4%
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Talanta
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Talanta
1 publication, 4%
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Advanced healthcare materials
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Advanced healthcare materials
1 publication, 4%
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Molecular Therapy - Nucleic Acids
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Molecular Therapy - Nucleic Acids
1 publication, 4%
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Journal of Chemical Theory and Computation
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Journal of Chemical Theory and Computation
1 publication, 4%
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Acta Biomaterialia
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Acta Biomaterialia
1 publication, 4%
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Drug Delivery and Translational Research
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Drug Delivery and Translational Research
1 publication, 4%
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Journal of Colloid and Interface Science
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Journal of Colloid and Interface Science
1 publication, 4%
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1
2
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Citations by publishers
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1
2
3
4
5
6
7
8
9
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
9 publications, 36%
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Elsevier
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Elsevier
6 publications, 24%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
2 publications, 8%
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Wiley
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Wiley
2 publications, 8%
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American Institute of Physics (AIP)
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American Institute of Physics (AIP)
1 publication, 4%
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Mary Ann Liebert
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Mary Ann Liebert
1 publication, 4%
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IOP Publishing
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IOP Publishing
1 publication, 4%
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Springer Nature
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Springer Nature
1 publication, 4%
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1
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9
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Kolovskaya O. S. et al. Aptamer-Conjugated Superparamagnetic Ferroarabinogalactan Nanoparticles for Targeted Magnetodynamic Therapy of Cancer // Cancers. 2020. Vol. 12. No. 1. p. 216.
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Kolovskaya O. S., Zamay T. N., Zamay G. S., Babkin V. A., Medvedeva E. N., Neverova N. A., Kirichenko A. K., Zamay S. S., Lapin I. N., Morozov E. V., Sokolov A. E., Narodov A. A., Fedorov D. V., Tomilin F. N., Zabluda V. N., Alekhina Y., Lukyanenko K. A., Glazyrin Y. E., Svetlichnyi V., Berezovski M. V., Kichkailo A. S. Aptamer-Conjugated Superparamagnetic Ferroarabinogalactan Nanoparticles for Targeted Magnetodynamic Therapy of Cancer // Cancers. 2020. Vol. 12. No. 1. p. 216.
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TY - JOUR
DO - 10.3390/cancers12010216
UR - https://doi.org/10.3390%2Fcancers12010216
TI - Aptamer-Conjugated Superparamagnetic Ferroarabinogalactan Nanoparticles for Targeted Magnetodynamic Therapy of Cancer
T2 - Cancers
AU - Kolovskaya, Olga S
AU - Zamay, Galina S
AU - Babkin, Vasily A
AU - Neverova, Nadezhda A
AU - Kirichenko, Andrey K.
AU - Lapin, Ivan N
AU - Sokolov, Alexey E
AU - Narodov, Andrey A
AU - Zabluda, Vladimir N
AU - Zamay, Tatiana N.
AU - Medvedeva, Elena N
AU - Zamay, Sergey S
AU - Alekhina, Yulia
AU - Morozov, E. V.
AU - Fedorov, D. V.
AU - Tomilin, Felix N.
AU - Lukyanenko, Kirill A.
AU - Glazyrin, Yury E.
AU - Svetlichnyi, Valery
AU - Berezovski, Maxim V.
AU - Kichkailo, Anna S.
PY - 2020
DA - 2020/01/15 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 216
IS - 1
VL - 12
PMID - 31952299
SN - 2072-6694
ER -
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@article{2020_Kolovskaya,
author = {Olga S Kolovskaya and Galina S Zamay and Vasily A Babkin and Nadezhda A Neverova and Andrey K. Kirichenko and Ivan N Lapin and Alexey E Sokolov and Andrey A Narodov and Vladimir N Zabluda and Tatiana N. Zamay and Elena N Medvedeva and Sergey S Zamay and Yulia Alekhina and E. V. Morozov and D. V. Fedorov and Felix N. Tomilin and Kirill A. Lukyanenko and Yury E. Glazyrin and Valery Svetlichnyi and Maxim V. Berezovski and Anna S. Kichkailo},
title = {Aptamer-Conjugated Superparamagnetic Ferroarabinogalactan Nanoparticles for Targeted Magnetodynamic Therapy of Cancer},
journal = {Cancers},
year = {2020},
volume = {12},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {jan},
url = {https://doi.org/10.3390%2Fcancers12010216},
number = {1},
pages = {216},
doi = {10.3390/cancers12010216}
}
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Kolovskaya, Olga S., et al. “Aptamer-Conjugated Superparamagnetic Ferroarabinogalactan Nanoparticles for Targeted Magnetodynamic Therapy of Cancer.” Cancers, vol. 12, no. 1, Jan. 2020, p. 216. https://doi.org/10.3390%2Fcancers12010216.