Open Access
Recent Advances in the Treatment of Bone Metastases and Primary Bone Tumors: An Up-to-Date Review
Adrian Emilian Bădilă
1, 2
,
Dragoș Mihai Rădulescu
1, 2
,
Adelina-Gabriela Niculescu
3
,
Alexandru Mihai Grumezescu
3, 4, 5
,
Marius Rădulescu
6
,
Adrian Radu Rădulescu
1, 2
2
5
Academy of Romanian Scientists, 3 Ilfov Street, 50044 Bucharest, Romania
|
Publication type: Journal Article
Publication date: 2021-08-23
PubMed ID:
34439383
Cancer Research
Oncology
Abstract
In the last decades, the treatment of primary and secondary bone tumors has faced a slow-down in its development, being mainly based on chemotherapy, radiotherapy, and surgical interventions. However, these conventional therapeutic strategies present a series of disadvantages (e.g., multidrug resistance, tumor recurrence, severe side effects, formation of large bone defects), which limit their application and efficacy. In recent years, these procedures were combined with several adjuvant therapies, with different degrees of success. To overcome the drawbacks of current therapies and improve treatment outcomes, other strategies started being investigated, like carrier-mediated drug delivery, bone substitutes for repairing bone defects, and multifunctional scaffolds with bone tissue regeneration and antitumor properties. Thus, this paper aims to present the types of bone tumors and their current treatment approaches, further focusing on the recent advances in new therapeutic alternatives.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
3
4
|
|
|
Pharmaceutics
4 publications, 4.65%
|
|
|
International Journal of Molecular Sciences
4 publications, 4.65%
|
|
|
Frontiers in Bioengineering and Biotechnology
3 publications, 3.49%
|
|
|
Free Radical Biology and Medicine
2 publications, 2.33%
|
|
|
Discover Oncology
2 publications, 2.33%
|
|
|
Biomedicines
2 publications, 2.33%
|
|
|
Materials
1 publication, 1.16%
|
|
|
Current Oncology
1 publication, 1.16%
|
|
|
Frontiers in Materials
1 publication, 1.16%
|
|
|
Frontiers in Medicine
1 publication, 1.16%
|
|
|
Molecules
1 publication, 1.16%
|
|
|
Carbohydrate Polymers
1 publication, 1.16%
|
|
|
Scientific Reports
1 publication, 1.16%
|
|
|
ACS applied materials & interfaces
1 publication, 1.16%
|
|
|
Drug Delivery
1 publication, 1.16%
|
|
|
Physician Assistant Clinics
1 publication, 1.16%
|
|
|
Cell Communication and Signaling
1 publication, 1.16%
|
|
|
ACS Applied Bio Materials
1 publication, 1.16%
|
|
|
Bone and soft tissue sarcomas, tumors of the skin
1 publication, 1.16%
|
|
|
Biomaterials Research
1 publication, 1.16%
|
|
|
Frontiers in Endocrinology
1 publication, 1.16%
|
|
|
Critical Reviews in Oncology/Hematology
1 publication, 1.16%
|
|
|
Postgraduate Medical Journal
1 publication, 1.16%
|
|
|
Applied Radiation and Isotopes
1 publication, 1.16%
|
|
|
Clinical Orthopaedics and Related Research
1 publication, 1.16%
|
|
|
World Journal of Clinical Cases
1 publication, 1.16%
|
|
|
Cell Proliferation
1 publication, 1.16%
|
|
|
Lipids in Health and Disease
1 publication, 1.16%
|
|
|
Journal Archives of Health
1 publication, 1.16%
|
|
|
1
2
3
4
|
Publishers
|
5
10
15
20
|
|
|
MDPI
20 publications, 23.26%
|
|
|
Elsevier
20 publications, 23.26%
|
|
|
Springer Nature
15 publications, 17.44%
|
|
|
Frontiers Media S.A.
7 publications, 8.14%
|
|
|
Wiley
4 publications, 4.65%
|
|
|
American Chemical Society (ACS)
3 publications, 3.49%
|
|
|
Taylor & Francis
3 publications, 3.49%
|
|
|
Institute of Electrical and Electronics Engineers (IEEE)
3 publications, 3.49%
|
|
|
Ovid Technologies (Wolters Kluwer Health)
2 publications, 2.33%
|
|
|
Walter de Gruyter
2 publications, 2.33%
|
|
|
Publishing House ABV Press
1 publication, 1.16%
|
|
|
Oxford University Press
1 publication, 1.16%
|
|
|
Baishideng Publishing Group
1 publication, 1.16%
|
|
|
South Florida Publishing LLC
1 publication, 1.16%
|
|
|
Royal Society of Chemistry (RSC)
1 publication, 1.16%
|
|
|
5
10
15
20
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
86
Total citations:
86
Citations from 2024:
58
(67.45%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Bădilă A. E. et al. Recent Advances in the Treatment of Bone Metastases and Primary Bone Tumors: An Up-to-Date Review // Cancers. 2021. Vol. 13. No. 16. p. 4229.
GOST all authors (up to 50)
Copy
Bădilă A. E., Rădulescu D. M., Niculescu A., Grumezescu A. M., Rădulescu M., Rădulescu A. R. Recent Advances in the Treatment of Bone Metastases and Primary Bone Tumors: An Up-to-Date Review // Cancers. 2021. Vol. 13. No. 16. p. 4229.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3390/cancers13164229
UR - https://doi.org/10.3390/cancers13164229
TI - Recent Advances in the Treatment of Bone Metastases and Primary Bone Tumors: An Up-to-Date Review
T2 - Cancers
AU - Bădilă, Adrian Emilian
AU - Rădulescu, Dragoș Mihai
AU - Niculescu, Adelina-Gabriela
AU - Grumezescu, Alexandru Mihai
AU - Rădulescu, Marius
AU - Rădulescu, Adrian Radu
PY - 2021
DA - 2021/08/23
PB - MDPI
SP - 4229
IS - 16
VL - 13
PMID - 34439383
SN - 2072-6694
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2021_Bădilă,
author = {Adrian Emilian Bădilă and Dragoș Mihai Rădulescu and Adelina-Gabriela Niculescu and Alexandru Mihai Grumezescu and Marius Rădulescu and Adrian Radu Rădulescu},
title = {Recent Advances in the Treatment of Bone Metastases and Primary Bone Tumors: An Up-to-Date Review},
journal = {Cancers},
year = {2021},
volume = {13},
publisher = {MDPI},
month = {aug},
url = {https://doi.org/10.3390/cancers13164229},
number = {16},
pages = {4229},
doi = {10.3390/cancers13164229}
}
Cite this
MLA
Copy
Bădilă, Adrian Emilian, et al. “Recent Advances in the Treatment of Bone Metastases and Primary Bone Tumors: An Up-to-Date Review.” Cancers, vol. 13, no. 16, Aug. 2021, p. 4229. https://doi.org/10.3390/cancers13164229.