The Chemical Inhibitors of Endocytosis: From Mechanisms to Potential Clinical Applications

Olga Klaudia Szewczyk ¹

Piotr Roszczenko ²

Anna A. Shmakova ³

Nataliya Finiuk ⁴

Serhii Holota ⁵

Roman Lesyk ⁵

Anna Bielawska ²

Yegor S. Vassetzky ³

Krzysztof Bielawski ¹

Show full list: 9 authors

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Department of Synthesis and Technology of Drugs, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, Poland |

Department of Biotechnology, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, Poland |

CNRS, UMR 9018, Institut Gustave Roussy, Université Paris-Saclay, 94800 Villejuif, France

⁴

Department of Regulation of Cell Proliferation and Apoptosis, Institute of Cell Biology of National Academy of Sciences of Ukraine, Drahomanov 14/16, 79005 Lviv, Ukraine |

⁵

Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, 79010 Lviv, Ukraine |

Publication type: Journal Article

Publication date: 2023-09-19

MDPI

Journal: Cells

scimago Q1

SJR: 1.547

CiteScore: 9.9

Impact factor: 5.1

ISSN: 20734409

DOI: 10.3390/cells12182312

Copy DOI

PubMed ID: 37759535

General Medicine

Abstract

Endocytosis is one of the major ways cells communicate with their environment. This process is frequently hijacked by pathogens. Endocytosis also participates in the oncogenic transformation. Here, we review the approaches to inhibit endocytosis, discuss chemical inhibitors of this process, and discuss potential clinical applications of the endocytosis inhibitors.

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