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Current Issues in Molecular Biology, volume 46, issue 7, pages 7303-7323

Lonicera japonica Thunb. Ethanol Extract Exerts a Protective Effect on Normal Human Gastric Epithelial Cells by Modulating the Activity of Tumor-Necrosis-Factor-α-Induced Inflammatory Cyclooxygenase 2/Prostaglandin E2 and Matrix Metalloproteinase 9

Hsi-Lung Hsieh 1, 2, 3
Ming-Chin Yu 4, 5, 6
Yuan-Shiun Chang 1
Yi-Hsuan Wu 1
Kuo-Hsiung Huang 7, 8
Ming-Ming Tsai 1, 4, 6, 7
2
 
Department of Neurology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
4
 
Department of General Surgery, New Taipei Municipal Tucheng Hospital, New Taipei 236, Taiwan
6
 
Department of General Surgery, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
8
 
Department of Laboratory Medicine, Section of Clinical Serology and Immunology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
Publication typeJournal Article
Publication date2024-07-09
Quartile SCImago
Q2
Quartile WOS
Q3
Impact factor3.1
ISSN14673037, 14673045
Abstract

Gastric inflammation-related disorders are commonly observed digestive system illnesses characterized by the activation of proinflammatory cytokines, particularly tumor necrosis factor-α (TNF-α). This results in the induction of cyclooxygenase-2 (COX-2)/prostaglandin E2 (PEG2) and matrix metallopeptidase-9 (MMP-9). These factors contribute to the pathogenesis of gastric inflammation disorders. We examined the preventive effects of Lonicera japonica Thunb. ethanol extract (Lj-EtOH) on gastric inflammation induced by TNF-α in normal human gastric mucosa epithelial cells (GES-1). The GES-1 cell line was used to establish a model that simulated the overexpression of COX-2/PGE2 and MMP-9 proteins induced by TNF-α to examine the anti-inflammatory properties of Lj extracts. The results indicated that Lj-EtOH exhibits significant inhibitory effects on COX-2/PEG2 and MMP-9 activity, attenuates cell migration, and provides protection against TNF-α-induced gastric inflammation. The protective effects of Lj-EtOH are associated with the modulation of COX-2/PEG2 and MMP-9 through the activation of TNFR–ERK 1/2 signaling pathways as well as the involvement of c-Fos and nuclear factor kappa B (NF-κB) signaling pathways. Based on our findings, Lj-EtOH exhibits a preventive effect on human gastric epithelial cells. Consequently, it may represent a novel treatment for the management of gastric inflammation.

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Hsieh H. et al. Lonicera japonica Thunb. Ethanol Extract Exerts a Protective Effect on Normal Human Gastric Epithelial Cells by Modulating the Activity of Tumor-Necrosis-Factor-α-Induced Inflammatory Cyclooxygenase 2/Prostaglandin E2 and Matrix Metalloproteinase 9 // Current Issues in Molecular Biology. 2024. Vol. 46. No. 7. pp. 7303-7323.
GOST all authors (up to 50) Copy
Hsieh H., Yu M., Chang Y., Wu Y., Huang K., Tsai M. Lonicera japonica Thunb. Ethanol Extract Exerts a Protective Effect on Normal Human Gastric Epithelial Cells by Modulating the Activity of Tumor-Necrosis-Factor-α-Induced Inflammatory Cyclooxygenase 2/Prostaglandin E2 and Matrix Metalloproteinase 9 // Current Issues in Molecular Biology. 2024. Vol. 46. No. 7. pp. 7303-7323.
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TY - JOUR
DO - 10.3390/cimb46070433
UR - https://www.mdpi.com/1467-3045/46/7/433
TI - Lonicera japonica Thunb. Ethanol Extract Exerts a Protective Effect on Normal Human Gastric Epithelial Cells by Modulating the Activity of Tumor-Necrosis-Factor-α-Induced Inflammatory Cyclooxygenase 2/Prostaglandin E2 and Matrix Metalloproteinase 9
T2 - Current Issues in Molecular Biology
AU - Hsieh, Hsi-Lung
AU - Yu, Ming-Chin
AU - Chang, Yuan-Shiun
AU - Wu, Yi-Hsuan
AU - Huang, Kuo-Hsiung
AU - Tsai, Ming-Ming
PY - 2024
DA - 2024/07/09
PB - MDPI
SP - 7303-7323
IS - 7
VL - 46
SN - 1467-3037
SN - 1467-3045
ER -
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@article{2024_Hsieh,
author = {Hsi-Lung Hsieh and Ming-Chin Yu and Yuan-Shiun Chang and Yi-Hsuan Wu and Kuo-Hsiung Huang and Ming-Ming Tsai},
title = {Lonicera japonica Thunb. Ethanol Extract Exerts a Protective Effect on Normal Human Gastric Epithelial Cells by Modulating the Activity of Tumor-Necrosis-Factor-α-Induced Inflammatory Cyclooxygenase 2/Prostaglandin E2 and Matrix Metalloproteinase 9},
journal = {Current Issues in Molecular Biology},
year = {2024},
volume = {46},
publisher = {MDPI},
month = {jul},
url = {https://www.mdpi.com/1467-3045/46/7/433},
number = {7},
pages = {7303--7323},
doi = {10.3390/cimb46070433}
}
MLA
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Hsieh, Hsi-Lung, et al. “Lonicera japonica Thunb. Ethanol Extract Exerts a Protective Effect on Normal Human Gastric Epithelial Cells by Modulating the Activity of Tumor-Necrosis-Factor-α-Induced Inflammatory Cyclooxygenase 2/Prostaglandin E2 and Matrix Metalloproteinase 9.” Current Issues in Molecular Biology, vol. 46, no. 7, Jul. 2024, pp. 7303-7323. https://www.mdpi.com/1467-3045/46/7/433.
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