Headache and Facial Pain in Multiple Sclerosis: A Narrative Review

Lukasz Kolakowski ¹

Katarina Alexandra Ebner ^{1, 2}

Athina Papadopoulou ^{1, 2}

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Department of Neurology, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland |

Department of Clinical Research, University of Basel, Spitalstrasse 8, CH-4031 Basel, Switzerland

Publication type: Journal Article

Publication date: 2025-03-06

MDPI

Journal: Clinical and Translational Neuroscience

SJR: —

CiteScore: —

Impact factor: —

ISSN: 2514183X

DOI: 10.3390/ctn9010016

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Abstract

Headache and facial pain syndromes are frequently observed in people with multiple sclerosis (MS), often affecting young adults during pivotal stages of their lives. These conditions can disrupt their ability to work, maintain relationships, and engage in daily activities, leading to significant socio-economic and personal challenges. This narrative review summarizes key epidemiological data and diagnostic insights into headache and facial pain disorders in people with MS. It addresses the complexities of diagnosing these overlapping conditions and highlights specific therapeutic considerations.